KEGG   DRUG: Patisiran sodiumHelp
Entry
D10794                      Drug                                   

Name
Patisiran sodium (JAN);
Onpattro (TN)
Product
Formula
C412H480N148O290P40.40Na
Exact mass
14297.2775
Mol weight
14303.5785
Sequence
RNA: auggaauacu cuugguuact t
complex with RNA: guaaccaaga guauuccaut t
  Type
Nucleotide
Remark
ATC code: N07XX12
Chemical structure group: DG02955
Product (DG02955): D10794<US>
Efficacy
Gene expression regulator, Prealbumin expression inhibitor
  Disease
Hereditary transthyretin-mediated amyloidosis [DS:H00845]
Comment
RNA interference (RNAi) drug
Treatment of hereditary ATTR amyloidosis
Target
TTR [HSA:7276] [KO:K20731] (mRNA)
  Pathway
hsa04918  Thyroid hormone synthesis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX12 Patisiran
      D10794  Patisiran sodium (JAN) <US>
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Others
    TTR
     D10794  Patisiran sodium (JAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10794
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10794
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10794
BRITE hierarchy
Other DBs
CAS: 1386913-72-9
PubChem: 316933530
LinkDB All DBs

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