KEGG   DRUG: Omidenepag isopropyl
Entry
D10966                      Drug                                   
Name
Omidenepag isopropyl (JAN);
Eybelis (TN);
Omlonti (TN)
Product
OMLONTI (Ocuvex Therapeutics)
Formula
C26H28N6O4S
Exact mass
520.1893
Mol weight
520.61
Structure
Simcomp
Class
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Metabolizing enzyme substrate
 DG02970  CES substrate
  DG03241  CES1 substrate
Remark
Therapeutic category: 1319
ATC code: S01EX06
Chemical structure group: DG02831
Product (DG02831): D10966<JP/US>
Efficacy
Antiglaucoma, Prostaglandin E2 receptor agonist
  Disease
Open-angle glaucoma [DS:H00612]
Target
PTGER2 [HSA:5732] [KO:K04259]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CES1 [HSA:1066]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX06 Omidenepag
      D10966  Omidenepag isopropyl (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D10966  Omidenepag isopropyl (JAN)
Drug groups [BR:br08330]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG02831  Omidenepag
    D10966  Omidenepag isopropyl
 Metabolizing enzyme substrate
  DG02970  CES substrate
   DG03241  CES1 substrate
    DG02831  Omidenepag
     D10966  Omidenepag isopropyl
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D10966  Omidenepag isopropyl
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    PTGER2
     D10966  Omidenepag isopropyl (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10966
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10966
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10966
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10966
Drug groups [BR:br08330]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG02831  Omidenepag
 Metabolizing enzyme substrate
  DG02970  CES substrate
   DG03241  CES1 substrate
    DG02831  Omidenepag
Other DBs
CAS: 1187451-19-9
PubChem: 342581815
LinkDB
KCF data

ATOM        37
            1   C8x C    13.9307  -13.0205
            2   C8x C    13.9307  -14.4206
            3   C8y C    15.1432  -15.1206
            4   N5x N    16.3558  -14.4206
            5   C8y C    16.3558  -13.0205
            6   C8x C    15.1432  -12.3205
            7   C1b C    15.1432  -16.5205
            8   N1c N    16.3389  -17.2110
            9   C1b C    17.5261  -16.5255
            10  S4a S    16.3391  -18.6205
            11  C8y C    18.7176  -17.2136
            12  C8x C    18.7176  -18.6205
            13  C8x C    19.9301  -19.3206
            14  C8y C    21.1427  -18.6205
            15  C8x C    21.1427  -17.2135
            16  C8x C    19.9301  -16.5134
            17  N4y N    22.3541  -19.3200
            18  C8x C    22.5003  -20.7108
            19  C8x C    23.8681  -21.0015
            20  C8x C    24.5674  -19.7904
            21  N5x N    23.6316  -18.7513
            22  C8y C    15.1055  -19.3331
            23  C8x C    13.8992  -18.6368
            24  N5x N    12.6867  -19.3371
            25  C8x C    12.6869  -20.7372
            26  C8x C    13.8932  -21.4334
            27  C8x C    15.1057  -20.7332
            28  N1b N    17.5933  -12.3205
            29  C1b C    18.8059  -13.0205
            30  C7a C    20.0184  -12.3205
            31  O7a O    21.2309  -13.0205
            32  C1c C    22.4434  -12.3205
            33  O6a O    20.0184  -10.9204
            34  C1a C    23.6766  -13.0327
            35  C1a C    22.4435  -10.9207
            36  O3c O    17.7391  -18.6205
            37  O3c O    17.0391  -19.8331
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1
            11    9  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   14  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   17  21 1
            24   10  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   22  27 1
            31    5  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   30  33 2
            37   32  34 1
            38   32  35 1
            39   10  36 2
            40   10  37 2

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