| Entry |
|
|---|
| Name |
Velmanase alfa (INN) |
|---|
| Sequence |
GGYETCPTVQ PNMLNVHLLP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY ILDSVISALL
ADPTRRFIYV EIAFFSRWWH QQTNATQEVV RDLVRQGRLE FANGGWVMND EAATHYGAIV
DQMTLGLRFL EDTFGNDGRP RVAWHIDPFG HSREQASLFA QMGFDGFFFG RLDYQDKWVR
MQKLEMEQVW RASTSLKPPT ADLFTGVLPN GYNPPRNLCW DVLCVDQPLV EDPRSPEYNA
KELVDYFLNV ATAQGRYYRT NHTVMTMGSD FQYENANMWF KNLDKLIRLV NAQQAKGSSV
HVLYSTPACY LWELNKANLT WSVKHDDFFP YADGPHQFWT GYFSSRPALK RYERLSYNFL
QVCNQLEALV GLAANVGPYG SGDSAPLNEA MAVLQHHDAV SGTSRQHVAN DYARQLAAGW
GPCEVLLSNA LARLRGFKDH FTFCQQLNIS ICPLSQTAAR FQVIVYNPLG RKVNWMVRLP
VSEGVFVVKD PNGRTVPSDV VIFPSSDSQA HPPELLFSAS LPALGFSTYS VAQVPRWKPQ
ARAPQPIPRR SWSPALTIEN EHIRATFDPD TGLLMEIMNM NQQLLLPVRQ TFFWYNASIG
DNESDQASGA YIFRPNQQKP LPVSRWAQIH LVKTPLVQEV HQNFSAWCSQ VVRLYPGQRH
LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG REILERRRDY RPTWKLNQTE
PVAGNYYPVN TRIYITDGNM QLTVLTDRSQ GGSSLRDGSL ELMVHRRLLK DDGRGVSEPL
MENGSGAWVR GRHLVLLDTA QAAAAGHRLL AEQEVLAPQV VLAPGGGAAY NLGAPPRTQF
SGLRRDLPPS VHLLTLASWG PEMVLLRLEH QFAVGEDSGR NLSAPVTLNL RDLFSTFTIT
RLQETTLVAN QLREAASRLK WTTNTGPTPH QTPYQLDPAN ITLEPMEIRT FLASVQWKEV
DG
(Disulfide bridge: 6-39, 219-224, 363-423, 444-452) |
|---|
| Type |
Peptide |
|---|
| Remark |
|
|---|
| Efficacy |
Lysosomal storage disease treatment, Enzyme replacement (alpha-mannosidase) |
|---|
| Comment |
Enzyme replacement therapy product
Treatment of alpha-Mannosidosis
|
|---|
| Target |
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|---|
| Pathway |
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|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16AB Enzymes
A16AB15 Velmanase alfa
D11024 Velmanase alfa (INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Glycosidases
MAN2B1* [HSA_VAR:4125v1]
D11024 Velmanase alfa (INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D11024
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D11024
Pharmacogenomic biomarkers [br08341.html]
Germline mutations in genetic disorder treatments
D11024
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| Other DBs |
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| LinkDB |
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