KEGG   DRUG: Velmanase alfa
Entry
D11024                      Drug                                   
Name
Velmanase alfa (USAN/INN);
Velmanase alfa-tycv;
Lamzede (TN)
Product
LAMZEDE (Chiesi USA)
Sequence
GGYETCPTVQ PNMLNVHLLP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY ILDSVISALL
ADPTRRFIYV EIAFFSRWWH QQTNATQEVV RDLVRQGRLE FANGGWVMND EAATHYGAIV
DQMTLGLRFL EDTFGNDGRP RVAWHIDPFG HSREQASLFA QMGFDGFFFG RLDYQDKWVR
MQKLEMEQVW RASTSLKPPT ADLFTGVLPN GYNPPRNLCW DVLCVDQPLV EDPRSPEYNA
KELVDYFLNV ATAQGRYYRT NHTVMTMGSD FQYENANMWF KNLDKLIRLV NAQQAKGSSV
HVLYSTPACY LWELNKANLT WSVKHDDFFP YADGPHQFWT GYFSSRPALK RYERLSYNFL
QVCNQLEALV GLAANVGPYG SGDSAPLNEA MAVLQHHDAV SGTSRQHVAN DYARQLAAGW
GPCEVLLSNA LARLRGFKDH FTFCQQLNIS ICPLSQTAAR FQVIVYNPLG RKVNWMVRLP
VSEGVFVVKD PNGRTVPSDV VIFPSSDSQA HPPELLFSAS LPALGFSTYS VAQVPRWKPQ
ARAPQPIPRR SWSPALTIEN EHIRATFDPD TGLLMEIMNM NQQLLLPVRQ TFFWYNASIG
DNESDQASGA YIFRPNQQKP LPVSRWAQIH LVKTPLVQEV HQNFSAWCSQ VVRLYPGQRH
LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG REILERRRDY RPTWKLNQTE
PVAGNYYPVN TRIYITDGNM QLTVLTDRSQ GGSSLRDGSL ELMVHRRLLK DDGRGVSEPL
MENGSGAWVR GRHLVLLDTA QAAAAGHRLL AEQEVLAPQV VLAPGGGAAY NLGAPPRTQF
SGLRRDLPPS VHLLTLASWG PEMVLLRLEH QFAVGEDSGR NLSAPVTLNL RDLFSTFTIT
RLQETTLVAN QLREAASRLK WTTNTGPTPH QTPYQLDPAN ITLEPMEIRT FLASVQWKEV
DG
(Disulfide bridge: 6-39, 219-224, 363-423, 444-452)
  Type
Peptide
Remark
ATC code: A16AB15
Product: D11024<US>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (alpha-mannosidase)
  Disease
alpha-Mannosidosis [DS:H00139]
Comment
Enzyme replacement therapy product
Treatment of alpha-Mannosidosis
Target
MAN2B1* [HSA_VAR:4125v1] [HSA:4125] [KO:K12311]
  Pathway
hsa00511  Other glycan degradation
hsa04142  Lysosome
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB15 Velmanase alfa
      D11024  Velmanase alfa (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Glycosidases
    MAN2B1* [HSA_VAR:4125v1]
     D11024  Velmanase alfa (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11024
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11024
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11024
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D11024
Other DBs
CAS: 1492823-75-2
PubChem: 350078343
LinkDB

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