KEGG   DRUG: Idursulfase beta
Entry
D11025                      Drug                                   

Name
Idursulfase beta (INN);
Idursulfase beta (genetical recombination) (JAN);
Hunterase (TN)
Formula
C2689H4051N699O793S13
Exact mass
59238.4521
Mol weight
59274.9897
Sequence
SETQANSTTD ALNVLLIIVD DLRPSLGCYG DKLVRSPNID QLASHSLLFQ NAFAQQAVCA
PSRVSFLTGR RPDTTRLYDF NSYWRVHAGN FSTIPQYFKE NGYVTMSVGK VFHPGISSNH
TDDSPYSWSF PPYHPSSEKY ENTKTCRGPD GELHANLLCP VDVLDVPEGT LPDKQSTEQA
IQLLEKMKTS ASPFFLAVGY HKPHIPFRYP KEFQKLYPLE NITLAPDPEV PDGLPPVAYN
PWMDIRQRED VQALNISVPY GPIPVDFQRK IRQSYFASVS YLDTQVGRLL SALDDLQLAN
STIIAFTSDH GWALGEHGEW AKYSNFDVAT HVPLIFYVPG RTASLPEAGE KLFPYLDPFD
SASQLMEPGR QSMDLVELVS LFPTLAGLAG LQVPPRCPVP SFHVELCREG KNLLKHFRFR
DLEEDPYLPG NPRELIAYSQ YPRPSDIPQW NSDKPSLKDI KIMGYSIRTI DYRYTVWVGF
NPDEFLANFS DIHAGELYFV DSDPLQDHNM YNDSQGGDLF QLLMP
(Disulfide bridge: 146-159, 397-407)
  Type
Peptide
Remark
ATC code: A16AB16
Product: D11025<JP>
Efficacy
Lysosomal storage disease treatment, Enzyme replacement (iduronate-2-sulfatase)
Comment
Enzyme replacement therapy product
Treatment of Hunter syndrome
Target
IDS* [HSA_VAR:3423v1] [HSA:3423] [KO:K01136]
  Network
N10013  Replacement of deficient IDS
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB16 Idursulfase beta
      D11025  Idursulfase beta (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Sulfatases
    IDS* [HSA_VAR:3423v1]
     D11025  Idursulfase beta (INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11025
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11025
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D11025
Other DBs
CAS: 1271734-34-9
PubChem: 350078344
LinkDB

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