KEGG   DRUG: CenegerminHelp
Entry
D11028                      Drug                                   

Name
Cenegermin (INN);
Cenegermin-bkbj;
Oxervate (TN)
Product
Sequence
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD
PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
(Disulfide bridge: 15-80, 58-108, 68-110)
  Type
Peptide
Remark
ATC code: S01XA24
Product: D11028<US>
Efficacy
Antiglaucoma, Neuroprotectant
Comment
recombinant human nerve growth factor [HSA:4803] [KO:K02582]
Treatment of moderate to severe neurotrophic keratitis
Target
NGFR (TNFRSF16, CD271) [HSA:4804] [KO:K02583]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04722  Neurotrophin signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA24 Cenegermin
      D11028  Cenegermin (INN) <US>
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    NGFR (TNFRSF16, CD271)
     D11028  Cenegermin (INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11028
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11028
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11028
BRITE hierarchy
Other DBs
CAS: 1772578-74-1
PubChem: 350078347
LinkDB All DBs

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