| Entry |
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|---|
| Name |
Brolucizumab (USAN/INN);
Brolucizumab (genetical recombination) (JAN);
Brolucizuab-dbll;
Beovu (TN)
|
|---|
| Formula |
C1164H1768N310O372S8
|
|---|
| Exact mass |
26296.6724
|
|---|
| Mol weight |
26312.8665
|
|---|
| Sequence |
MEIVMTQSPS TLSASVGDRV IITCQASEII HSWLAWYQQK PGKAPKLLIY LASTLASGVP
SRFSGSGSGA EFTLTISSLQ PDDFATYYCQ NVYLASTNGA NFGQGTKLTV LGGGGGSGGG
GSGGGGSGGG GSEVQLVESG GGLVQPGGSL RLSCTASGFS LTDYYYMTWV RQAPGKGLEW
VGFIDPDDDP YYATWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAG GDHNSGWGLD
IWGQGTLVTV SS
(Disulfide bridge: 24-89, 154-228) |
|---|
| Type |
Peptide |
|---|
| Remark |
| Therapeutic category: | 1319 |
|
|---|
| Efficacy |
Age-related macular degeneration therapeutic agent, Anti-VEGF antibody |
|---|
| Disease |
Age-related macular degeneration [DS: H00821] |
|---|
| Comment |
Monoclonal antibody
Treatment of wet age-related macular degeneration
|
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| Target |
|
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| Pathway |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01L OCULAR VASCULAR DISORDER AGENTS
S01LA Antineovascularisation agents
S01LA06 Brolucizumab
D11083 Brolucizumab (USAN/INN) <JP>
USP drug classification [BR:br08302]
Ophthalmic Agents
Ophthalmic Agents, Other
Vascular Endothelial Growth Factor (VEGF) Inhibitor
Brolucizumab
D11083 Brolucizumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D11083 Brolucizumab (USAN/INN); Brolucizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
Cytokines
Growth factors (RTK-binding)
VEGFA
D11083 Brolucizumab (USAN/INN) <JP>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D11083
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D11083
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D11083
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D11083
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| Other DBs |
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| LinkDB |
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