Homo sapiens (human): 7422
Help
Entry
7422 CDS
T01001
Symbol
VEGFA, L-VEGF, MVCD1, VEGF, VPF
Name
(RefSeq) vascular endothelial growth factor A
KO
K05448
vascular endothelial growth factor A
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa04926
Relaxin signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05219
Bladder cancer
hsa05323
Rheumatoid arthritis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06219
JAK-STAT signaling (cancer)
nt06225
HIF-1 signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06262
Pancreatic cancer
nt06264
Renal cell carcinoma
nt06360
Cushing syndrome
nt06526
MAPK signaling
nt06528
Calcium signaling
nt06530
PI3K signaling
nt06542
HIF signaling
Element
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00095
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00317
AhR signaling pathway
N01412
Metals to HTF-1 signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01641
RTK-PLCG-ITPR signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
N01870
HIF-2A signaling pathway
N01873
VHL mutation to HIF-2 signaling pathway
Disease
H01456
Diabetic nephropathy
H01457
Diabetic retinopathy
H01459
Diabetic neuropathy
H01529
Avascular necrosis of femoral head
H02559
Microvascular complications of diabetes
Drug target
Abicipar pegol:
D11517
Aflibercept:
D09574
<JP/US>
Aflibercept beta:
D10819
<JP>
Bevacizumab:
D06409
<JP/US>
Bevasiranib sodium:
D08874
Brolucizumab:
D11083
<JP/US>
Dilpacimab:
D11642
Emvododstat:
D11890
Faricimab:
D11516
<JP/US>
Ivonescimab:
D12808
Navicixizumab:
D11126
Pegaptanib:
D05386
Ranibizumab:
D05697
<JP/US>
Tarcocimab:
D12507
Tarcocimab tedromer:
D12508
Vanucizumab:
D11244
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
7422 (VEGFA)
04015 Rap1 signaling pathway
7422 (VEGFA)
04066 HIF-1 signaling pathway
7422 (VEGFA)
04151 PI3K-Akt signaling pathway
7422 (VEGFA)
09150 Organismal Systems
09152 Endocrine system
04926 Relaxin signaling pathway
7422 (VEGFA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7422 (VEGFA)
05206 MicroRNAs in cancer
7422 (VEGFA)
05205 Proteoglycans in cancer
7422 (VEGFA)
05207 Chemical carcinogenesis - receptor activation
7422 (VEGFA)
05208 Chemical carcinogenesis - reactive oxygen species
7422 (VEGFA)
09162 Cancer: specific types
05212 Pancreatic cancer
7422 (VEGFA)
05211 Renal cell carcinoma
7422 (VEGFA)
05219 Bladder cancer
7422 (VEGFA)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
7422 (VEGFA)
05167 Kaposi sarcoma-associated herpesvirus infection
7422 (VEGFA)
05165 Human papillomavirus infection
7422 (VEGFA)
09163 Immune disease
05323 Rheumatoid arthritis
7422 (VEGFA)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
7422 (VEGFA)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
7422 (VEGFA)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
7422 (VEGFA)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
7422 (VEGFA)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7422 (VEGFA)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Growth factors (RTK binding)
7422 (VEGFA)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
7422 (VEGFA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
VEGF_C
PDGF
Ribosomal_60s
Motif
Other DBs
NCBI-GeneID:
7422
NCBI-ProteinID:
NP_003367
OMIM:
192240
HGNC:
12680
Ensembl:
ENSG00000112715
UniProt:
P15692
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:43770211..43786487
Genome browser
AA seq
395 aa
AA seq
DB search
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLG
CSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWT
GEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQ
DPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
NT seq
1188 nt
NT seq
+upstream
nt +downstream
nt
ctgacggacagacagacagacaccgcccccagccccagctaccacctcctccccggccgg
cggcggacagtggacgcggcggcgagccgcgggcaggggccggagcccgcgcccggaggc
ggggtggagggggtcggggctcgcggcgtcgcactgaaacttttcgtccaacttctgggc
tgttctcgcttcggaggagccgtggtccgcgcgggggaagccgagccgagcggagccgcg
agaagtgctagctcgggccgggaggagccgcagccggaggagggggaggaggaagaagag
aaggaagaggagagggggccgcagtggcgactcggcgctcggaagccgggctcatggacg
ggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcc
cgggcctcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccc
cacagcccgagccggagagggagcgcgagccgcgccggccccggtcgggcctccgaaacc
atgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccat
gccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtg
gtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggac
atcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctg
atgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtcc
aacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatg
agcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaa
aaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccggtat
aagtcctggagcgttccctgtgggccttgctcagagcggagaaagcatttgtttgtacaa
gatccgcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcag
cttgagttaaacgaacgtacttgcagatgtgacaagccgaggcggtga
DBGET
integrated database retrieval system
