Entry |
|
Name |
Ivosidenib (USAN/INN); Tibsovo (TN) |
Product |
|
Formula |
C28H22ClF3N6O3
|
Exact mass |
582.1394
|
Mol weight |
582.9609
|
Structure |

|
Remark |
|
Efficacy |
Antineoplastic, Isocitrate dehydrogenase 1 inhibitor |
Disease |
Acute myeloid leukemia (susceptible IDH1 mutation) [DS: H00003] |
Comment |
Treatment of cancer
|
Target |
|
Pathway |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XX Other antineoplastic agents
L01XX62 Ivosidenib
D11090 Ivosidenib (USAN/INN) <US>
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Ivosidenib
D11090 Ivosidenib (USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
IDH1* [HSA_VAR:3417v1]
D11090 Ivosidenib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D11090
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D11090
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
D11090
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 41
1 C8y C 24.4300 -17.5000
2 C8x C 24.4300 -18.9000
3 C8y C 25.6424 -19.6000
4 C8x C 26.8549 -18.9000
5 N5x N 26.8549 -17.5000
6 C8x C 25.6424 -16.8000
7 N1c N 23.2176 -16.8000
8 C5a C 22.0221 -17.4904
9 C1y C 20.8347 -16.8049
10 O5a O 22.0220 -18.8997
11 C1x C 20.4190 -15.4713
12 C1x C 19.0170 -15.4545
13 C5x C 18.5678 -16.7826
14 N1y N 19.6921 -17.6202
15 C8y C 19.6778 -19.0400
16 C8x C 18.4525 -19.7311
17 C8y C 18.5084 -21.1311
18 C8x C 19.6438 -21.8432
19 C8x C 20.8691 -21.1520
20 N5x N 20.8832 -19.7521
21 C3b C 17.2721 -21.8478
22 N3a N 16.0596 -22.5478
23 X F 25.6424 -20.9998
24 O5x O 17.2101 -17.2056
25 C1c C 23.2175 -14.8402
26 C5a C 22.0219 -14.1498
27 C8y C 24.4468 -14.1303
28 C8x C 25.6508 -14.8254
29 C8x C 26.8632 -14.1253
30 C8x C 26.8632 -12.7253
31 C8x C 25.6592 -12.0302
32 C8y C 24.4467 -12.7303
33 O5a O 22.0219 -12.7498
34 N1b N 20.8348 -14.8352
35 C1y C 19.6424 -14.1404
36 C1x C 19.6995 -12.7406
37 C1z C 18.2997 -12.7535
38 C1x C 18.2426 -14.1533
39 X F 17.3045 -11.7261
40 X F 16.9005 -13.2609
41 X Cl 23.2260 -12.0255
BOND 45
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 1
9 9 8 1 #Up
10 8 10 2
11 9 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 9 14 1
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 17 21 1
24 21 22 3
25 3 23 1
26 13 24 2
27 25 7 1 #Down
28 25 26 1
29 25 27 1
30 27 28 2
31 28 29 1
32 29 30 2
33 30 31 1
34 31 32 2
35 27 32 1
36 26 33 2
37 26 34 1
38 34 35 1
39 35 36 1
40 36 37 1
41 37 38 1
42 35 38 1
43 37 39 1
44 37 40 1
45 32 41 1
|