Entry |
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Name |
Cholangiocarcinoma |
Supergrp |
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Description |
Cholangiocarcinoma is a highly malignant neoplasm that carries a poor prognosis and lacks effective therapy. It is the second most common primary hepatic tumor, and it is increasing in incidence and carries a high mortality. The tumor arises from the ductular epithelium of the biliary tree, either within the liver (intrahepatic cholangiocarcinoma: ICC) or more commonly from the extrahepatic bile ducts (extrahepatic cholangiocarcinoma). Several studies have demonstrated mutations resulting in overexpression of K-ras and p53 genes. These genetic alterations are associated with a more aggressive phenotype in this cancer. Many reports have implicated overexpression of the tyrosine kinase proto-oncogenes c-erbB-2 (HER-2/neu) and c-Met, as well as cyclo-oxygenase-2 (COX-2) activity in intrahepatic cholangiocarcinoma.
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Category |
Cancer
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Brite |
Human diseases [BR:br08402]
Cancers
Cancers of the digestive system
H00046 Cholangiocarcinoma
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of digestive organs
2C12 Malignant neoplasms of liver or intrahepatic bile ducts
H00046 Cholangiocarcinoma
Tumor markers [br08442.html]
H00046
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Gene |
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Carcinogen |
Opisthorchis viverrini (infection with)
Radium-224 and its decay products [CPD: C16455]
*Chimney sweeping
*2,3,7,8-Tetrachlorodibenzo-para-dioxin [CPD: C07557]
*Thorium-232 and its decay products, administered intravenously as a colloidal dispersion of thorium232 dioxide
*Tobacco smoking and tobacco smoke
*: Although this is a risk factor for liver cancer in general, the strength of association with different histological tumor types is not well understood.
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Pathogen |
Opisthorchis viverrini [GN: ovi] |
Drug |
Pemigatinib [DR: D11417] (FGFR2 fusion positive)
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Comment |
ICD-O: 8160/3, Tumor type: Intrahepatic cholangiocarcinoma
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Other DBs |
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Reference |
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Authors |
Olnes MJ, Erlich R. |
Title |
A review and update on cholangiocarcinoma. |
Journal |
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Reference |
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Authors |
Fava G, Marzioni M, Benedetti A, Glaser S, DeMorrow S, Francis H, Alpini G. |
Title |
Molecular pathology of biliary tract cancers. |
Journal |
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Reference |
|
Authors |
Lazaridis KN, Gores GJ. |
Title |
Cholangiocarcinoma. |
Journal |
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Reference |
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Authors |
Khurana S, Dubey ML, Malla N. |
Title |
Association of parasitic infections and cancers. |
Journal |
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Reference |
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Authors |
Herrera LA, Benitez-Bribiesca L, Mohar A, Ostrosky-Wegman P. |
Title |
Role of infectious diseases in human carcinogenesis. |
Journal |
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Reference |
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Authors |
Nekolla EA, Kellerer AM, Kuse-Isingschulte M, Eder E, Spiess H. |
Title |
Malignancies in patients treated with high doses of radium-224. |
Journal |
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Reference |
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Authors |
Boffetta P, Jourenkova N, Gustavsson P. |
Title |
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. |
Journal |
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Reference |
|
Authors |
Luch A. |
Title |
Nature and nurture - lessons from chemical carcinogenesis. |
Journal |
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Reference |
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Authors |
Harrison JD, Muirhead CR. |
Title |
Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation. |
Journal |
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LinkDB |
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