KEGG   DRUG: Filgotinib maleate
Entry
D11106                      Drug                                   
Name
Filgotinib maleate (JAN/USAN);
Jyseleca (TN)
Formula
C21H23N5O3S. C4H4O4
Exact mass
541.1631
Mol weight
541.5762
Structure
Simcomp
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG02020  JAK inhibitor
Metabolizing enzyme substrate
 DG02970  CES substrate
  DG03241  CES1 substrate
  DG03192  CES2 substrate
Remark
Therapeutic category: 3999
ATC code: L04AF04
Chemical structure group: DG01991
Product (DG01991): D11106<JP>
Efficacy
Anti-inflammatory, Janus kinase (JAK) inhibitor
Comment
Treatment of inflammatory conditions and autoimmune diseases
Target
JAK1 [HSA:3716] [KO:K11217]
JAK2 [HSA:3717] [KO:K04447]
JAK3 [HSA:3718] [KO:K11218]
TYK2 [HSA:7297] [KO:K11219]
  Pathway
hsa04630  JAK-STAT signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
Metabolism
Enzyme: CES1 [HSA:1066], CES2 [HSA:8824]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AF Janus-associated kinase (JAK) inhibitors
     L04AF04 Filgotinib
      D11106  Filgotinib maleate (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11106  Filgotinib maleate (JAN/USAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG02020  JAK inhibitor
    DG01991  Filgotinib
     D11106  Filgotinib maleate
 Metabolizing enzyme substrate
  DG02970  CES substrate
   DG03241  CES1 substrate
    DG01991  Filgotinib
     D11106  Filgotinib maleate
   DG03192  CES2 substrate
    DG01991  Filgotinib
     D11106  Filgotinib maleate
Drug classes [BR:br08332]
 Immunological agent
  DG02020  JAK inhibitor
   D11106  Filgotinib maleate
 Antirheumatic agent
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   D11106  Filgotinib maleate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   JAK family
    JAK1
     D11106  Filgotinib maleate (JAN/USAN) <JP>
    JAK2
     D11106  Filgotinib maleate (JAN/USAN) <JP>
    JAK3
     D11106  Filgotinib maleate (JAN/USAN) <JP>
    TYK2
     D11106  Filgotinib maleate (JAN/USAN) <JP>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11106
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11106
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11106
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11106
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG02020  JAK inhibitor
    DG01991  Filgotinib
 Metabolizing enzyme substrate
  DG02970  CES substrate
   DG03241  CES1 substrate
    DG01991  Filgotinib
   DG03192  CES2 substrate
    DG01991  Filgotinib
Other DBs
CAS: 1802998-75-9
PubChem: 376219030
LinkDB
KCF data

ATOM        38
            1   C8x C    13.9868  -12.3084
            2   C8x C    13.9868  -10.9097
            3   C8x C    15.1756  -10.2103
            4   C8y C    16.4344  -10.9097
            5   N4y N    16.4344  -12.3084
            6   C8y C    15.1756  -13.0077
            7   N5x N    17.7632  -10.4901
            8   C8y C    18.5325  -11.6090
            9   N5x N    17.7632  -12.7280
            10  N1b N    19.9311  -11.6090
            11  C5a C    20.6305  -12.7979
            12  C1y C    22.0291  -12.7979
            13  O5a O    19.9311  -13.9868
            14  C1x C    23.2880  -12.0985
            15  C1x C    23.2880  -13.4972
            16  C8y C    15.1756  -14.4064
            17  C8x C    16.3645  -15.1057
            18  C8x C    16.3645  -16.5044
            19  C8y C    15.1057  -17.2037
            20  C8x C    13.9168  -16.5044
            21  C8x C    13.9168  -15.1057
            22  C1b C    15.1057  -18.6024
            23  N1y N    16.2946  -19.3017
            24  C1x C    16.2946  -20.7004
            25  C1x C    17.5534  -21.3997
            26  S2x S    18.7423  -20.7004
            27  C1x C    18.7423  -19.3017
            28  C1x C    17.4835  -18.6024
            29  O3c O    18.7423  -22.0991
            30  O3c O    19.9311  -20.0011
            31  C2b C    23.5900  -15.5400
            32  C2b C    24.9900  -15.5400
            33  C6a C    22.8900  -16.7524
            34  C6a C    25.6900  -16.7524
            35  O6a O    27.0898  -16.7524
            36  O6a O    24.9996  -17.9479
            37  O6a O    21.4902  -16.7524
            38  O6a O    23.5804  -17.9479
BOND        41
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 2
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15   12  14 1
            16   14  15 1
            17   12  15 1
            18    6  16 1
            19   16  17 2
            20   17  18 1
            21   18  19 2
            22   19  20 1
            23   20  21 2
            24   16  21 1
            25   19  22 1
            26   22  23 1
            27   23  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   23  28 1
            33   26  29 2
            34   26  30 2
            35   31  32 2
            36   31  33 1
            37   32  34 1
            38   34  35 2
            39   34  36 1
            40   33  37 1
            41   33  38 2

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