KEGG   ORTHOLOGY: K11218
Entry
K11218                      KO                                     

Symbol
JAK3
Name
Janus kinase 3 [EC:2.7.10.2]
Pathway
map04062  Chemokine signaling pathway
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04550  Signaling pathways regulating pluripotency of stem cells
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map05161  Hepatitis B
map05162  Measles
map05166  Human T-cell leukemia virus 1 infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05223  Non-small cell lung cancer
map05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K11218  JAK3; Janus kinase 3
   04151 PI3K-Akt signaling pathway
    K11218  JAK3; Janus kinase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11218  JAK3; Janus kinase 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11218  JAK3; Janus kinase 3
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K11218  JAK3; Janus kinase 3
   04659 Th17 cell differentiation
    K11218  JAK3; Janus kinase 3
   04062 Chemokine signaling pathway
    K11218  JAK3; Janus kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11218  JAK3; Janus kinase 3
   05203 Viral carcinogenesis
    K11218  JAK3; Janus kinase 3
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K11218  JAK3; Janus kinase 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K11218  JAK3; Janus kinase 3
   05161 Hepatitis B
    K11218  JAK3; Janus kinase 3
   05162 Measles
    K11218  JAK3; Janus kinase 3
   05169 Epstein-Barr virus infection
    K11218  JAK3; Janus kinase 3
  09163 Immune disease
   05340 Primary immunodeficiency
    K11218  JAK3; Janus kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K11218  JAK3; Janus kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11218  JAK3; Janus kinase 3
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K11218  JAK3; Janus kinase 3
Other DBs
GO: 0004715
Genes
HSA: 3718(JAK3)
PPS: 100972035(JAK3)
PON: 100433988(JAK3)
NLE: 100603367
MCC: 114669853 720040(JAK3)
MCF: 102134669(JAK3)
CSAB: 103234155(JAK3)
CATY: 105601679(JAK3)
PANU: 101014985(JAK3)
RRO: 104660959(JAK3)
RBB: 108534230(JAK3)
TFN: 117076455(JAK3)
PTEH: 111554242(JAK3)
CJC: 100397491(JAK3)
SBQ: 101034707(JAK3)
MMUR: 105854990(JAK3)
MMU: 16453(Jak3)
MCAL: 110299617(Jak3)
MPAH: 110337003(Jak3)
RNO: 25326(Jak3)
MCOC: 116069528(Jak3)
MUN: 110549202(Jak3)
CGE: 100773497(Jak3)
PLEU: 114687957(Jak3)
NGI: 103726892(Jak3)
HGL: 101715472(Jak3)
CPOC: 100713900(Jak3)
CCAN: 109698332(Jak3)
OPI: 101527090(JAK3)
TUP: 102471949(JAK3)
CFA: 610004(JAK3)
VVP: 112913173(JAK3)
VLG: 121494166(JAK3)
AML: 100474005(JAK3)
UMR: 103675167(JAK3)
UAH: 113256691(JAK3)
ORO: 101369142(JAK3)
ELK: 111143876
MPUF: 101687161(JAK3)
EJU: 114196399(JAK3)
MLX: 118005338(JAK3)
FCA: 101092339(JAK3)
PYU: 121010992(JAK3)
PBG: 122487079(JAK3)
PTG: 102966280(JAK3)
PPAD: 109247962(JAK3)
AJU: 106969157(JAK3)
HHV: 120239234(JAK3)
BTA: 538276(JAK3)
BOM: 102286011(JAK3)
BIU: 109561426(JAK3)
BBUB: 102400750(JAK3)
CHX: 102171504(JAK3)
OAS: 101112816(JAK3)
ODA: 120864206(JAK3)
CCAD: 122440727(JAK3)
SSC: 100518649(JAK3)
CFR: 102503866(JAK3)
CBAI: 105082560(JAK3)
CDK: 105101858(JAK3)
BACU: 103012385(JAK3)
LVE: 103081519(JAK3)
OOR: 101283171(JAK3)
DLE: 111166590(JAK3)
PCAD: 102990026(JAK3)
PSIU: 116751653(JAK3)
ECB: 100147451(JAK3)
EPZ: 103542314(JAK3)
EAI: 106830858(JAK3)
MYB: 102241153(JAK3)
MYD: 102767426(JAK3)
MMYO: 118658721(JAK3)
MLF: 102428976(JAK3)
MNA: 107535380(JAK3)
PKL: 118725867(JAK3)
HAI: 109382346(JAK3)
DRO: 112305180(JAK3)
SHON: 118975019(JAK3)
AJM: 119046817(JAK3)
PDIC: 114503157(JAK3)
MMF: 118615617(JAK3)
RFQ: 117038244(JAK3)
PALE: 102898620(JAK3)
PGIG: 120606540(JAK3)
PVP: 105296612(JAK3)
RAY: 107521798(JAK3)
MJV: 108388002(JAK3)
TOD: 119241109(JAK3)
LAV: 100665896(JAK3)
TMU: 101345231
MDO: 100010720(JAK3)
SHR: 100920108(JAK3)
PCW: 110223345(JAK3)
OAA: 100085612(JAK3)
GGA: 395845(JAK3)
PCOC: 116235744(JAK3)
MGP: 100544996(JAK3)
CJO: 107325427(JAK3)
NMEL: 110389100(JAK3)
TGU: 100223256(JAK3)
LSR: 110482487(JAK3)
PMOA: 120513789(JAK3)
OTC: 121342709(JAK3)
PRUF: 121360822(JAK3)
GFR: 102039894(JAK3)
PHI: 102110608(JAK3)
CCW: 120411448
ETL: 114071733(JAK3)
FPG: 101914306(JAK3)
FCH: 102054762(JAK3)
CLV: 102096086(JAK3)
NNI: 104013697(JAK3)
TALA: 116963228(JAK3) 122153645
AAM: 106486617(JAK3)
AROW: 112965665(JAK3)
NPD: 112949079(JAK3)
DNE: 112992767(JAK3)
ASN: 102382453(JAK3)
AMJ: 102570658(JAK3)
CPOO: 109318698(JAK3)
GGN: 109288774(JAK3)
PSS: 102443764(JAK3)
CMY: 102943900(JAK3)
CPIC: 101946232(JAK3)
CABI: 116833572(JAK3)
MRV: 120391643(JAK3)
PVT: 110072505(JAK3)
SUND: 121936923(JAK3)
PBI: 103062083(JAK3)
VKO: 123018709(JAK3)
PMUA: 114588430(JAK3)
ZVI: 118087504(JAK3)
GJA: 107120632(JAK3)
XLA: 378531(jak3.L)
XTR: 100135373(jak3)
NPR: 108790798(JAK3)
DRE: 561370(jak3)
SRX: 107758021
SANH: 107699083(jak3)
CCAR: 109099581
IPU: 108265879(jak3)
PHYP: 113525138
AMEX: 103027049
EEE: 113587959(jak3)
TRU: 101073316
LCO: 104927912
NCC: 104958015
CGOB: 115007263(jak3)
ELY: 117253555(jak3)
PLEP: 121965471(jak3)
SLUC: 116055396(jak3)
ECRA: 117950578(jak3)
PFLV: 114561281
GAT: 120824062(jak3)
PPUG: 119217060(jak3)
MSAM: 119900536(jak3)
CUD: 121512655(jak3)
MZE: 101474045
ONL: 100704264
OAU: 116328450(jak3)
OLA: 101175555
OML: 112150124(jak3)
XMA: 102229490(jak3)
XCO: 114150903(jak3)
XHE: 116726392(jak3)
PRET: 103463505(jak3)
GAF: 122838848(jak3)
CVG: 107093314(jak3)
CTUL: 119787611(jak3)
NFU: 107392807
KMR: 108234253(jak3)
ALIM: 106519218(jak3)
AOCE: 111576548(jak3)
CSEM: 103395797(jak3)
POV: 109636537
SSEN: 122780559(jak3)
HHIP: 117760267(jak3)
LCF: 108881187
SDU: 111218194(jak3)
SLAL: 111669976(jak3)
XGL: 120790633(jak3)
HCQ: 109519009
BPEC: 110160225
MALB: 109958189
SASA: 106573870(jak3)
OTW: 112252160(jak3)
OMY: 110496854(jak3)
SALP: 111953034
SNH: 120053737(jak3)
ELS: 105011431
SFM: 108930599(jak3)
PKI: 111860336(jak3)
AANG: 118226427(jak3)
LOC: 102692715(jak3)
BPYO: 122577017
FAS: 105271102
DAM: 107040808
CCIN: 107264899
BGT: 106067432
 » show all
Reference
PMID:8022790
  Authors
Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR, et al.
  Title
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
  Journal
Proc Natl Acad Sci U S A 91:6374-8 (1994)
DOI:10.1073/pnas.91.14.6374
  Sequence
[hsa:3718]
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