KEGG   DRUG: EmapalumabHelp
Entry
D11120                      Drug                                   

Name
Emapalumab (USAN/INN);
Emapalumab-lzsg;
Gamifant (TN)
Product
Formula
C6430H9898N1718O2038S46
Exact mass
145261.0846
Mol weight
145350.6689
Sequence
(Heavy chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKDG SSGWYVPHWF DPWGQGTLVT
VSSASTKGPS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKR VEPKSCDKTH TCPPCPAPEL
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS
REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
NFMLTQPHSV SESPGKTVTI SCTRSSGSIA SNYVQWYQQR PGSSPTTVIY EDNQRPSGVP
DRFSGSIDSS SNSASLTISG LKTEDEADYY CQSYDGSNRW MFGGGTKLTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: H22-H96, H150-H206, H226-L216, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'150-H'206, H'226-L'216, H'267-H'327, H'373-H'431, L22-L91, L139-L198, L'22-L'91, L'139-L'198)
  Type
Peptide
Remark
ATC code: L04AA39
Product: D11120<US>
Efficacy
Antineoplastic, Anti-INF-gamma antibody
  Disease
Primary hemophagocytic lymphohistiocytosis [DS:H00109]
Comment
Monoclonal antibody
Treatment of hemophagocytic lymphohistiocytosis (HLH) and other conditions
Target
IFNG [HSA:3458] [KO:K04687]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA39 Emapalumab
      D11120  Emapalumab (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interferons
    IFNG
     D11120  Emapalumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D11120
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11120
BRITE hierarchy
Other DBs
CAS: 1709815-23-5
PubChem: 376219044
LinkDB All DBs

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