KEGG ORTHOLOGY: K04687

ORTHOLOGY: K04687

Entry

K04687                      KO

Symbol

IFNG

Name

interferon gamma

Pathway

map03050

Proteasome

map04060

Cytokine-cytokine receptor interaction

map04066

HIF-1 signaling pathway

map04217

Necroptosis

map04350

TGF-beta signaling pathway

map04380

Osteoclast differentiation

map04612

Antigen processing and presentation

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04940

Type I diabetes mellitus

map05140

Leishmaniasis

map05142

Chagas disease

map05143

African trypanosomiasis

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05160

Hepatitis C

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05200

Pathways in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05322

Systemic lupus erythematosus

map05323

Rheumatoid arthritis

map05330

Allograft rejection

map05332

Graft-versus-host disease

map05418

Fluid shear stress and atherosclerosis

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00342

Tuberculosis

H00413

Hepatitis C

H01132

Aplastic anemia

H01563

HIV infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K04687  IFNG; interferon gamma
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04687  IFNG; interferon gamma
   04630 JAK-STAT signaling pathway
    K04687  IFNG; interferon gamma
   04066 HIF-1 signaling pathway
    K04687  IFNG; interferon gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04687  IFNG; interferon gamma
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K04687  IFNG; interferon gamma
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04687  IFNG; interferon gamma
   04612 Antigen processing and presentation
    K04687  IFNG; interferon gamma
   04660 T cell receptor signaling pathway
    K04687  IFNG; interferon gamma
   04658 Th1 and Th2 cell differentiation
    K04687  IFNG; interferon gamma
   04659 Th17 cell differentiation
    K04687  IFNG; interferon gamma
   04657 IL-17 signaling pathway
    K04687  IFNG; interferon gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04687  IFNG; interferon gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04687  IFNG; interferon gamma
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04687  IFNG; interferon gamma
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04687  IFNG; interferon gamma
   05164 Influenza A
    K04687  IFNG; interferon gamma
   05168 Herpes simplex virus 1 infection
    K04687  IFNG; interferon gamma
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04687  IFNG; interferon gamma
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04687  IFNG; interferon gamma
   05144 Malaria
    K04687  IFNG; interferon gamma
   05145 Toxoplasmosis
    K04687  IFNG; interferon gamma
   05140 Leishmaniasis
    K04687  IFNG; interferon gamma
   05142 Chagas disease
    K04687  IFNG; interferon gamma
   05143 African trypanosomiasis
    K04687  IFNG; interferon gamma
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K04687  IFNG; interferon gamma
   05323 Rheumatoid arthritis
    K04687  IFNG; interferon gamma
   05321 Inflammatory bowel disease
    K04687  IFNG; interferon gamma
   05330 Allograft rejection
    K04687  IFNG; interferon gamma
   05332 Graft-versus-host disease
    K04687  IFNG; interferon gamma
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04687  IFNG; interferon gamma
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04687  IFNG; interferon gamma
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome
    K04687  IFNG; interferon gamma
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04687  IFNG; interferon gamma
   00536 Glycosaminoglycan binding proteins
    K04687  IFNG; interferon gamma
Proteasome [BR:ko03051]
Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    K04687  IFNG; interferon gamma
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Interferons
   K04687  IFNG; interferon gamma
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Cytokines
   K04687  IFNG; interferon gamma

Other DBs

GO:

0005133

Genes

HSA:	3458(IFNG)

PTR:	449517(IFNG)

PPS:	100991779(IFNG)

GGO:	101151755(IFNG)

PON:	100444043(IFNG)

PPYG:

129010659(IFNG)

NLE:	100583022(IFNG)

HMH:	116479646(IFNG)

SSYN:

129459762(IFNG)

MCC:	574282(IFNG)

MCF:	102128291(IFNG)

MTHB:

126930989

MNI:	105473416(IFNG)

CSAB:

103238673(IFNG)

CATY:

105600509(IFNG)

PANU:

100126724(IFNG)

TGE:	112634767(IFNG)

MLEU:

105537103(IFNG)

RRO:	104664085(IFNG)

RBB:	108532274(IFNG)

TFN:	117089783(IFNG)

PTEH:

111528616(IFNG)

CANG:

105502648(IFNG)

CJC:	100388952(IFNG)

SBQ:	101033464(IFNG)

CIMI:

108291791(IFNG)

ANAN:

105712036(IFNG)

CSYR:

103269019(IFNG)

MMUR:

105880942(IFNG)

LCAT:

123640661(IFNG)

PCOQ:

105808396(IFNG)

OGA:	100945607(IFNG)

MMU:	15978(Ifng)

MCAL:

110303854(Ifng)

MPAH:

110326932(Ifng)

RNO:	25712(Ifng)

MCOC:

116076208(Ifng)

ANU:	117696651(Ifng)

MUN:	110561827(Ifng)

CGE:	100768486(Ifng)

MAUA:

101825431(Ifng)

PROB:

127215720(Ifng)

PLEU:

114693330(Ifng)

MORG:

121456003(Ifng)

MFOT:

126515663

AAMP:

119803682(Ifng)

NGI:	103745085(Ifng)

HGL:	101700722(Ifng)

CPOC:

100379568(Ifng)

CCAN:

109676142(Ifng)

DORD:

105988764(Ifng)

DSP:	122124303(Ifng)

PLOP:

125347731(Ifng)

NCAR:

124983352

MMMA:

107140076(Ifng)

OCU:	100008602(IFNG)

OPI:	101517557(IFNG)

TUP:	102470542(IFNG)

GVR:	103605815 103609732

CFA:	403801(IFNG)

CLUD:

112677888(IFNG)

VVP:	112922237(IFNG)

VLG:	121491993(IFNG)

NPO:	129512215(IFNG)

AML:	100462659(IFNG)

UMR:	103656858(IFNG)

UAH:	113256304(IFNG)

UAR:	123787294(IFNG)

ELK:

111142126

LLV:

125107054

MPUF:

101693741(IFNG)

MNP:	132020570(IFNG)

MLK:	131839127(IFNG)

NVS:	122891375(IFNG)

ORO:	101382125(IFNG)

EJU:	114214991(IFNG)

ZCA:	113922097(IFNG)

MLX:	118008418(IFNG)

NSU:	110570569(IFNG)

LWW:	102733689(IFNG)

FCA:	493965(IFNG)

PYU:	121041076(IFNG)

PCOO:

112863468(IFNG)

PBG:	122473187(IFNG)

PVIV:

125170497(IFNG)

LRUF:

124502020

PTG:	102963756(IFNG)

PPAD:

109270472(IFNG)

PUC:

125919316

AJU:

106966359

HHV:	120240808(IFNG)

BTA:	281237(IFNG)

BOM:	102267095(IFNG)

BIU:	109558719(IFNG)

BBUB:

102416494(IFNG)

BBIS:

104989779(IFNG)

CHX:	100860815(IFNG)

OAS:	443396(IFNG)

BTAX:

128048506(IFNG)

CSUM:

138078463(IFNG)

ODA:	120857709(IFNG)

CCAD:

122427438(IFNG)

MREE:

136166154(IFNG)

MBEZ:

129536468(IFNG)

SSC:	396991(IFNG)

CFR:	102504614(IFNG)

CBAI:

105081344(IFNG)

CDK:	105101111(IFNG)

VPC:	102534412(IFNG)

BACU:

103020304(IFNG)

BMUS:

118902104(IFNG)

LVE:	103085542(IFNG)

OOR:	101282933(IFNG)

DLE:	111173770(IFNG)

PCAD:

102981551(IFNG)

PSIU:

116760539(IFNG)

NASI:

112394138(IFNG)

ECB:	100034181(IFNG)

EPZ:	103559339(IFNG)

EAI:	106843591(IFNG)

MYB:	102254028(IFNG)

MYD:	102774208(IFNG)

MMYO:

118651276(IFNG)

MLF:	102438946(IFNG)

MDT:	132226175(IFNG)

PKL:	118729249(IFNG)

EFUS:

103292513(IFNG)

MNA:	107527227(IFNG)

DRO:	112319176(IFNG)

SHON:

118989641(IFNG)

AJM:	119042309(IFNG)

PDIC:

114514094(IFNG)

PHAS:

123812973(IFNG)

MMF:	118624687(IFNG)

PPAM:

129076046(IFNG)

HAI:	109381671(IFNG)

RFQ:	117029185(IFNG)

PALE:

102882436(IFNG)

PGIG:

120604831(IFNG)

PVP:	105301262(IFNG)

RAY:	107512682(IFNG)

MJV:	108384008(IFNG)

TOD:	119248294(IFNG)

SARA:

101540972(IFNG)

SFUM:

130038886(IFNG)

SETR:

126022183(IFNG)

LAV:	100663285(IFNG)

TMU:

101346429

ETF:	101644328(IFNG)

DNM:	101422877(IFNG)

GAS:	123250180(IFNG)

SHR:	105750683(IFNG)

AFZ:

127564234

PCW:	110211092(IFNG)

TVP:	118849748 118849785 118851250

PBRV:

138156419(IFNG)

GGA:	396054(IFNG)

PCOC:

116226684(IFNG)

MGP:	100543502(IFNG)

CJO:	107310263(IFNG)

TPAI:

128073421(IFNG)

LMUT:

125688071(IFNG)

NMEL:

110392776(IFNG)

APLA:

101790439(IFNG)

ACYG:

106047018(IFNG)

CATA:

118246753(IFNG)

AFUL:

116498468(IFNG)

TGU:	100226664(IFNG)

LSR:	110479845(IFNG)

SCAN:

103820410(IFNG)

PMOA:

120499851(IFNG)

OTC:	121339489(IFNG)

PRUF:

121352566(IFNG)

GFR:	102042890(IFNG)

FAB:	101811885(IFNG)

OMA:	130266695(IFNG)

PHI:	102099074(IFNG)

PMAJ:

107204252(IFNG)

CCAE:

111937200(IFNG)

CCW:	104698369(IFNG)

CBRC:

103614813(IFNG)

ACOE:

138104638(IFNG)

ETL:	114062162(IFNG) 114073130

ZAB:	102062818(IFNG)

ZLE:	135456948(IFNG)

ACHL:

103808539(IFNG)

SVG:	106854918(IFNG)

MMEA:

130580121(IFNG)

HRT:	120751919(IFNG)

SATI:

136360871(IFNG)

FPG:	101924637(IFNG)

FCH:	102047662(IFNG)

CCRI:

104162832(IFNG)

NNT:	104405137(IFNG)

SHAB:

115605193(IFNG)

ACUN:

113491294(IFNG)

TALA:

104360421(IFNG)

ACHC:

115336262(IFNG)

HALD:

104313019(IFNG)

HLE:	104828216(IFNG)

AGEN:

126034474

HHAR:

128135561(IFNG)

GCL:

127025501

CSTI:

104560655(IFNG)

LDI:	104350455(IFNG)

MNB:	103777845(IFNG)

DPUB:

104305556(IFNG)

PPUS:

135187398

AVIT:

104277230

BRHI:

104490459(IFNG)

EGZ:	104132906(IFNG)

NNI:	104011009(IFNG)

PCRI:

104028074(IFNG)

PCAO:

104047403(IFNG)

PADL:

103919962(IFNG)

AFOR:

103893931(IFNG)

FGA:	104076437(IFNG)

GSTE:

104256440(IFNG)

CLV:	102098930(IFNG)

MUI:	104548570(IFNG)

PGUU:

104459797(IFNG)

PLET:

104616955(IFNG)

EHS:	104515339(IFNG)

CMAC:

104480124(IFNG)

CUCA:

104061369(IFNG)

TEO:	104380718(IFNG)

BREG:

104637613(IFNG)

OHA:	104326770(IFNG)

ACAR:

104524308(IFNG)

CPEA:

104388818(IFNG)

CVF:	104288925(IFNG)

RTD:	128917981(IFNG)

AAM:	106488479(IFNG)

AROW:

112970486(IFNG)

NPD:	112958855(IFNG)

TGT:	104574442(IFNG)

DNE:	112983337(IFNG)

SCAM:

104142049(IFNG)

ASN:	102383803 102384045

AMJ:	102563354(IFNG)

CPOO:

109315524(IFNG)

GGN:	109295707(IFNG)

PSS:	102444608(IFNG)

CMY:	102947470(IFNG)

CCAY:

125630233(IFNG)

DCC:	119849774(IFNG)

CPIC:

101934164(IFNG)

TST:	117868677(IFNG)

CABI:

116823551(IFNG)

MRV:	120387499(IFNG)

ASAO:

PVT:

SUND:

PBI:

PMUR:

107284417(IFNG)

CTIG:

120307681(IFNG)

PGUT:

117655711

APRI:

131202531(IFNG)

PTEX:

113438270(IFNG)

NSS:	113412210(IFNG)

VKO:

PMUA:

PRAF:

ZVI:

HCG:	128327334(IFNG)

GJA:

107105706

STOW:

125435373

EMC:

129335334

XLA:	101027283(ifng.L) 108712369

XTR:	100216446(ifng)

BBUF:

120980459

BGAR:

122928019

MUO:

115477759

GSH:	117363664(IL26)

DRE:	405790(ifng1)

CCAR:

109053615

CAUA:

113048607 113071150

CGIB:

127956722 127970345

PTET:

122342532(ifng1)

LROH:

127164339(ifng1)

OMC:	131539259(ifng1)

PPRM:

120476548(ifng1)

RKG:	130078769(ifng1)

MAMB:

125245511(ifng1)

CERY:

137023882(ifng1)

MASI:

127436954

TROS:

130547821(ifng1)

TDW:	130421118(ifng1)

MANU:

129432285(ifng1)

IPU:	100305073(ifng1)

IFU:	128623397(ifng1)

PHYP:

113532282

SMEO:

124401508(ifng1)

TFD:	113645804(ifng1)

TVC:	132859071(ifng1)

TRN:	134327187(ifng1)

CMAO:

118812488(ifng1)

SASA:

100329178

STRU:

115181896 115184184

OTW:	112237988(ifng1)

OMY:	100136643(ifng) 100301675(ifngamma2) 118938933

OGO:	124025543 124025544(ifng1)

OKI:	109885241 109885975 116360501 116364607 116364608

OKE:

127928176

SNH:	120049426 120049427 120049428

ELS:	105017796(ifng1)

SFM:

114909445

AANG:

118218838

LOC:

102691411

PSPA:

121317940(ifng1) 121319149

ARUT:

117415132 117419385(ifng1)

CMK:

RTP:

CPLA:

HOC:

Reference

PMID:24088808

Authors

Kunis G, Baruch K, Rosenzweig N, Kertser A, Miller O, Berkutzki T, Schwartz M

Title

IFN-gamma-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair.

Journal

Brain 136:3427-40 (2013)
DOI:10.1093/brain/awt259

Sequence

[hsa:3458]

Reference

PMID:2860101

Authors

Nishi T, Fujita T, Nishi-Takaoka C, Saito A, Matsumoto T, Sato M, Oka T, Itoh S, Yip YK, Vilcek J, et al.

Title

Cloning and expression of a novel variant of human interferon-gamma cDNA.

Journal

J Biochem 97:153-9 (1985)
DOI:10.1093/oxfordjournals.jbchem.a135039

Sequence

[hsa:3458]

LinkDB

DBGET integrated database retrieval system