KEGG   DRUG: CaplacizumabHelp
Entry
D11160                      Drug                                   

Name
Caplacizumab (USAN/INN);
Caplacizumab-yhdp;
Cablivi (TN)
Product
Formula
C1213H1891N357O380S10
Exact mass
27858.6828
Mol weight
27875.8075
Sequence
EVQLVESGGG LVQPGGSLRL SCAASGRTFS YNPMGWFRQA PGKGRELVAA ISRTGGSTYY
PDSVEGRFTI SRDNAKRMVY LQMNSLRAED TAVYYCAAAG VRAEDGRVRT LPSEYTFWGQ
GTQVTVSSAA AEVQLVESGG GLVQPGGSLR LSCAASGRTF SYNPMGWFRQ APGKGRELVA
AISRTGGSTY YPDSVEGRFT ISRDNAKRMV YLQMNSLRAE DTAVYYCAAA GVRAEDGRVR
TLPSEYTFWG QGTQVTVSS
(Disulfide bridge: 22-96, 153-227)
  Type
Peptide
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Remark
ATC code: B01AX07
Product: D11160<US>
Efficacy
Platelet aggregation inhibitor, Anti-vWF antibody
  Disease
Acquired thrombotic thrombocytopenic purpura [DS:H00225]
Comment
Monoclonal antibody
Treatment of thrombotic thrombocytopenic purpura, thrombosis
Target
VWF [HSA:7450] [KO:K03900]
  Pathway
hsa04610  Complement and coagulation cascades
hsa04611  Platelet activation
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AX Other antithrombotic agents
     B01AX07 Fondaparinux
      D11160  Caplacizumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    VWF
     D11160  Caplacizumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11160
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11160
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11160
BRITE hierarchy
Other DBs
CAS: 915810-67-2
PubChem: 376219084
LinkDB All DBs

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