KEGG ORTHOLOGY: K03900

ORTHOLOGY: K03900

Entry

K03900                      KO

Symbol

VWF

Name

von Willebrand factor

Pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04512

ECM-receptor interaction

map04610

Complement and coagulation cascades

map04611

Platelet activation

map04613

Neutrophil extracellular trap formation

map05165

Human papillomavirus infection

map05171

Coronavirus disease - COVID-19

Disease

H00219

Hemophilia

H01740

Macrothrombocytopenia

H02092

von Willebrand disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K03900  VWF; von Willebrand factor
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K03900  VWF; von Willebrand factor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K03900  VWF; von Willebrand factor
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03900  VWF; von Willebrand factor
   04611 Platelet activation
    K03900  VWF; von Willebrand factor
   04613 Neutrophil extracellular trap formation
    K03900  VWF; von Willebrand factor
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03900  VWF; von Willebrand factor
   05165 Human papillomavirus infection
    K03900  VWF; von Willebrand factor
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K03900  VWF; von Willebrand factor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03900  VWF; von Willebrand factor
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Others
   K03900  VWF; von Willebrand factor
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K03900  VWF; von Willebrand factor

Genes

HSA:

7450(VWF)

PTR:	451773(VWF)

PPS:	100985238(VWF)

GGO:	101142333(VWF)

PON:	100434817(VWF)

PPYG:

129009569(VWF)

NLE:	100580759(VWF)

HMH:	116472569(VWF)

SSYN:

129483487(VWF)

MCC:	722019(VWF)

MCF:	102132631(VWF)

MTHB:

126930424

MNI:	105484247(VWF)

CSAB:

103218442(VWF)

CATY:

105583007(VWF)

PANU:

101011576(VWF)

TGE:	112634393(VWF)

MLEU:

105541774(VWF)

RRO:	104680130(VWF)

RBB:	108536508(VWF)

TFN:	117090655(VWF)

PTEH:

111555950(VWF)

CANG:

105521211(VWF)

CJC:	100396684(VWF)

SBQ:	101044155(VWF)

CIMI:

108316350(VWF)

ANAN:

105719737(VWF)

CSYR:

103271056(VWF)

MMUR:

105869041(VWF)

LCAT:

123640137(VWF)

PCOQ:

105805087(VWF)

OGA:	100958412(VWF)

MMU:	22371(Vwf)

MCAL:

110295806(Vwf)

MPAH:

110316106(Vwf)

RNO:	116669(Vwf)

MCOC:

116099616(Vwf)

ANU:	117715558(Vwf)

MUN:	110548579(Vwf)

CGE:	100750531(Vwf)

MAUA:

101841493(Vwf)

PROB:

127213034(Vwf)

PLEU:

114708777(Vwf)

MORG:

121440884(Vwf)

MFOT:

126514861

AAMP:

119808130(Vwf)

NGI:	103727534(Vwf)

HGL:	101696988(Vwf)

CPOC:

100732530(Vwf)

CCAN:

109682788(Vwf)

DORD:

105991038(Vwf)

DSP:	122102538(Vwf)

NCAR:

124982604

MMMA:

107154977(Vwf)

OCU:	100009165(VWF)

OPI:	101530065(VWF)

TUP:	102483687(VWF)

GVR:	103600077(VWF)

CFA:	399544(VWF)

CLUD:

112669074(VWF)

VVP:	112917517(VWF)

VLG:	121479856(VWF)

NPO:	129503403(VWF)

AML:	100468710(VWF)

UMR:	103656237(VWF)

UAH:	113257990(VWF)

UAR:	123781568(VWF)

ELK:

111159823

LLV:

125106168

MPUF:

101677155(VWF)

MNP:	132019941(VWF)

MLK:	131838428(VWF)

NVS:	122892370(VWF)

ORO:	101385961(VWF)

EJU:	114222568(VWF)

ZCA:	113922860(VWF)

MLX:	118025754(VWF)

NSU:	110580753(VWF)

LWW:	102727918(VWF)

FCA:	493760(VWF)

PYU:	121021991(VWF)

PCOO:

112867211(VWF)

PBG:	122473269(VWF)

PVIV:

125170119(VWF)

LRUF:

124502187

PTG:	102965421(VWF)

PPAD:

109276146(VWF)

PUC:

125918758

AJU:

106965451

HHV:	120221153(VWF)

BTA:	280958(VWF)

BOM:	102282731(VWF)

BIU:	109558606(VWF)

BBUB:

102397126(VWF)

BBIS:

104992339(VWF)

CHX:	102191119(VWF)

OAS:	101110931(VWF)

BTAX:

128048587(VWF)

ODA:	120858705(VWF)

CCAD:

122423250(VWF)

MBEZ:

129535668(VWF)

SSC:	399543(VWF)

CFR:	102505067(VWF)

CBAI:

105071114(VWF)

CDK:	105098230(VWF)

VPC:	102543814(VWF)

BACU:

103021101(VWF)

BMUS:

118901659(VWF)

LVE:	103073004(VWF)

OOR:	101277710(VWF)

DLE:	111176651(VWF)

PCAD:

102980033(VWF)

PSIU:

116760832(VWF)

NASI:

112391767(VWF)

ECB:	100059472(VWF)

EPZ:	103546989(VWF)

EAI:	106831485(VWF)

MYB:	102248658(VWF)

MYD:	102769477(VWF)

MMYO:

118650211(VWF)

MLF:	102426871(VWF)

MDT:	132227175(VWF)

PKL:	118728821(VWF)

EFUS:

103288998(VWF)

MNA:	107544091(VWF)

DRO:	112321736(VWF)

SHON:

119002150(VWF)

AJM:	119060255(VWF)

PDIC:

114513096(VWF)

PHAS:

123810560(VWF)

MMF:	118623334(VWF)

PPAM:

129071415(VWF)

HAI:	109373317(VWF)

RFQ:	117028289(VWF)

PALE:

102891539(VWF)

PGIG:

120611627(VWF)

PVP:	105296024(VWF)

RAY:	107519777(VWF)

MJV:	108404459(VWF)

TOD:	119247802(VWF)

SARA:

101540741(VWF)

SETR:

126006504(VWF)

LAV:	100671560(VWF)

TMU:

101349323

ETF:	101651446(VWF)

DNM:	100913180(VWF)

MDO:	100014453(VWF)

GAS:	123248925(VWF)

SHR:	100933673(VWF)

AFZ:

127539006

PCW:	110213728(VWF)

TVP:	118849954(VWF)

OAA:	103166232(VWF)

GGA:	419031(VWF)

PCOC:

116231390(VWF)

MGP:

100540162

CJO:	107318080(VWF)

TPAI:

128084459(VWF)

LMUT:

125688435(VWF)

NMEL:

110397366(VWF)

APLA:

101800806(VWF)

ACYG:

106045477(VWF)

CATA:

118245001(VWF)

AFUL:

116493693(VWF)

TGU:	100228828(VWF)

LSR:	110475724(VWF)

SCAN:

103819672(VWF)

PMOA:

120507329(VWF)

OTC:	121347874(VWF)

PRUF:

121349677(VWF)

GFR:	102043317(VWF)

FAB:	101807556(VWF)

OMA:	130263831(VWF)

PHI:	102110108(VWF)

PMAJ:

107204805(VWF)

CCAE:

111923395(VWF)

CCW:	104696117(VWF)

CBRC:

103619963(VWF)

ETL:

114066532

ZAB:	102074171(VWF)

ZLE:	135442224(VWF)

ACHL:

103806623(VWF)

SVG:	106855918(VWF)

MMEA:

130585216(VWF)

HRT:	120752433(VWF)

SATI:

136361563(VWF)

FPG:	101921387(VWF)

FCH:	102052513(VWF)

NNT:	104405586(VWF)

SHAB:

115605615(VWF)

ACUN:

113490952(VWF)

TALA:

104367752(VWF)

ACHC:

115352510(VWF)

HLE:	104836638(VWF)

AGEN:

126047915

GCL:

127030012

LDI:	104346871(VWF)

MNB:	103775138(VWF)

DPUB:

104306305(VWF)

AVIT:

104273953(VWF)

EGZ:	104124217(VWF)

NNI:	104021755(VWF)

PCAO:

104052022(VWF)

PADL:

103917229(VWF)

AFOR:

103906569(VWF)

FGA:

104077165

GSTE:

104253915(VWF)

CLV:	102094798(VWF)

PGUU:

104463708(VWF)

PLET:

104618403(VWF)

CUCA:

104066615(VWF)

TEO:	104373286(VWF)

BREG:

104642122

OHA:	104333014(VWF)

ACAR:

104527382(VWF)

CPEA:

104395240(VWF)

CVF:	104288625(VWF)

RTD:	128917327(VWF)

AAM:	106488669(VWF)

AROW:

112973577(VWF)

NPD:	112942342(VWF)

TGT:	104577745(VWF)

DNE:	112984498(VWF)

SCAM:

104144413(VWF)

ASN:	102378714(VWF)

AMJ:	102568241(VWF)

CPOO:

109316284(VWF)

GGN:	109296558(VWF)

PSS:	102446530(VWF)

CMY:	102938529(VWF)

CCAY:

125623879(VWF)

DCC:	119849915(VWF)

CPIC:

101953722(VWF)

TST:	117884426(VWF)

CABI:

116824938(VWF)

MRV:	120405792(VWF)

ACS:	100560975(vwf)

ASAO:

132776432(VWF)

PVT:	110074979(VWF)

SUND:

121931398(VWF)

PBI:	103058879(VWF)

PMUR:

107298567(VWF)

CTIG:

120296801(VWF)

TSR:

106548389

PGUT:

117678913(VWF)

APRI:

131201640(VWF)

PTEX:

113433469(VWF)

NSS:	113419742(VWF)

VKO:

123017098

PMUA:

114596909(VWF)

PRAF:

128413579(VWF)

ZVI:	118096643(VWF)

HCG:	128328174(VWF)

GJA:	107108141(VWF)

STOW:

125443325(VWF)

EMC:	129344124(VWF)

XLA:	108710813(vwf.L)

XTR:	100492314(vwf)

NPR:	108792025(VWF)

RTEM:

120932631(VWF)

BBUF:

121007201(VWF)

BGAR:

122928319(VWF)

MUO:	115478245(VWF)

GSH:	117364352(VWF)

DRE:	570643(vwf)

SRX:	107736173(vwf)

SANH:

107662885(vwf)

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122362987(vwf)

LROH:

127180844(vwf)

OMC:	131524941(vwf)

PPRM:

120464851(vwf)

RKG:	130071321(vwf)

MAMB:

125254086(vwf)

CIDE:

127499310

CERY:

137023219(vwf)

MASI:

127456257

TROS:

130563288(vwf)

TDW:	130435282(vwf)

IPU:

108264049

IFU:	128606365(vwf)

PHYP:

113526338(vwf)

SMEO:

124395987(vwf)

TFD:	113649656(vwf)

TVC:	132851772(vwf)

TRN:	134323655(vwf)

AMEX:

103041546(vwf)

CMAO:

118817960(vwf)

EEE:	113580514(vwf)

CHAR:

105892545(vwf)

TRU:	101063204(vwf)

TFS:	130536128(vwf)

TNG:	GSTEN00035591G001

LCO:	104935215 104935217

NCC:	104957243(vwf)

TBEN:

117491826(vwf)

CGOB:

115009687(vwf)

PGEO:

117447685(vwf)

GACU:

117557700(vwf)

EMAC:

134883130(vwf)

ELY:	117262812(vwf)

EFO:	125887450(vwf)

PLEP:

121949858(vwf)

SLUC:

116045659(vwf)

ECRA:

117948863(vwf)

ESP:	116694167(vwf)

PFLV:

114560628

GAT:	120809004(vwf)

PPUG:

119196577(vwf)

AFB:	129108011(vwf)

CLUM:

117732767(vwf)

PSWI:

130195240(vwf)

MSAM:

119893265(vwf)

SCHU:

122875011(vwf)

CUD:	121515036(vwf)

ALAT:

119023809(vwf)

MZE:	101481554(vwf)

ONL:	100710915(vwf)

OAU:	116313499(vwf)

OLA:	101162365(vwf)

OML:	112152422(vwf)

CSAI:

133444276(vwf)

XMA:	102221825(vwf)

XCO:	114135853(vwf)

XHE:	116711338(vwf)

PRET:

103466661(vwf)

PFOR:

103133804(vwf)

PLAI:

106956229(vwf)

PMEI:

106915496(vwf)

GAF:	122835729(vwf)

PPRL:

129364262(vwf)

CVG:	107102395(vwf)

CTUL:

119772485(vwf)

GMU:	124877858(vwf)

NFU:	107388831(vwf)

KMR:	108230107(vwf)

ALIM:

106514310(vwf)

NWH:	119416426(vwf)

AOCE:

111571921(vwf)

MCEP:

125015133(vwf)

CSEM:

103380069(vwf)

POV:	109624060(vwf)

SSEN:

122776169(vwf)

HHIP:

117763362(vwf)

HSP:	118109952(vwf)

PPLT:

128444754(vwf)

SMAU:

118315516(vwf)

LCF:

108875127

SDU:	111228525(vwf)

SLAL:

111653371(vwf)

XGL:	120793073(vwf)

HCQ:	109528086(vwf)

SSCV:

125971070

SBIA:

133502767(vwf)

PEE:	133403341(vwf)

PTAO:

133478297(vwf)

BPEC:

110169224(vwf)

MALB:

109967704(vwf)

BSPL:

114857801(vwf)

SJO:	128359425(vwf)

SASA:

106561856

STRU:

115197755(vwf)

OTW:	112241769(vwf)

OMY:	110502677(vwf)

OGO:	124031463(vwf)

ONE:	115134824(vwf)

OKI:	109867065(vwf)

OKE:	118378237(vwf)

SNH:	120041576(vwf)

CCLU:

121559862(vwf)

ELS:	105029375(vwf)

SFM:	108920936(vwf)

PKI:	111837788(vwf)

AANG:

118231579(vwf)

LOC:	102692554(vwf)

PSPA:

121318560 121319503

ARUT:

117415837 117419959

PSEX:

120539660(vwf)

LCM:	102356867(VWF)

CMK:	103185564(vwf)

RTP:	109930160(vwf)

CPLA:

122561634(vwf)

HOC:	132826770(vwf)

LERI:

129707713

PMRN:

116956401(VWF)

BFO:	118404457 118413601

BBEL:

109475426 109484403 109486838

CIN:

104266451

SCLV:

120343047

DME:	Dmel_CG7002(Hml)

DER:

6545611

DSE:

6605606

DSI:	Dsimw501_GD14459(Dsim_GD14459)

DYA:	Dyak_GE21983

DAN:

DSR:

DPO:

DPE:

DMN:	108153130 108163659

DWI:

6639247

DGR:

6558716

DMO:	Dmoj_GI13091

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

CNS:

BCOO:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

PPYR:

116177255 116177256 116177357

OTU:	111424964 111427327

PCHN:

HAME:

PCLA:

HAZT:

ATEN:

Reference

PMID:3489923

Authors

Bonthron D, Orr EC, Mitsock LM, Ginsburg D, Handin RI, Orkin SH

Title

Nucleotide sequence of pre-pro-von Willebrand factor cDNA.

Journal

Nucleic Acids Res 14:7125-7 (1986)
DOI:10.1093/nar/14.17.7125

Sequence

[hsa:7450]

Reference

PMID:22890291

Authors

Luo GP, Ni B, Yang X, Wu YZ

Title

von Willebrand Factor: More Than a Regulator of Hemostasis and Thrombosis.

Journal

Acta Haematol 128:158-169 (2012)
DOI:10.1159/000339426

LinkDB

DBGET integrated database retrieval system