KEGG   DRUG: Vosoritide
Entry
D11190                      Drug                                   
Name
Vosoritide (USAN/INN);
Vosoritide (genetical recombination) (JAN);
Voxzogo (TN)
Product
Formula
C176H290N56O51S3
Exact mass
4100.0983
Mol weight
4102.7254
Sequence
PGQEHPNARK YKGANKKGLS KGCFGLKLDR IGSMSGLGC
(Disulfide bridge: 23-39)
  Type
Peptide
Remark
Therapeutic category: 3999
ATC code: M05BX07
Product: D11190<JP/US>
Efficacy
Achondroplasia therapeutic agent
  Disease
Achondroplasia [DS:H01749]
Comment
Treatment of Achondroplasia
modified recombinant human C-type natriuretic peptide (CNP)
Target
NPR2 [HSA:4882] [KO:K12324]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04921  Oxytocin signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BX Other drugs affecting bone structure and mineralization
     M05BX07 Vosoritide
      D11190  Vosoritide (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Vosoritide
   D11190  Vosoritide (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11190  Vosoritide (USAN/INN); Vosoritide (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    NPR2
     D11190  Vosoritide (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11190
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11190
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11190
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11190
Other DBs
CAS: 1480724-61-5
PubChem: 384585169
LinkDB

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