KEGG ORTHOLOGY: K12324

ORTHOLOGY: K12324

Entry

K12324                      KO

Symbol

ANPRB, NPR2

Name

atrial natriuretic peptide receptor B [EC:4.6.1.2]

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

map04022

cGMP-PKG signaling pathway

map04081

Hormone signaling

map04270

Vascular smooth muscle contraction

map04921

Oxytocin signaling pathway

Reaction

R00434

GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)

Disease

H00470

Acromesomelic dysplasia, Maroteaux type

H02543

Acromesomelic dysplasia

H02679

Miura-type epiphyseal chondrodysplasia

H02681

Short stature with nonspecific skeletal abnormalities

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
Enzymes [BR:ko01000]
4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  RGC family [OT]
   K12324  ANPRB, NPR2; atrial natriuretic peptide receptor B

Other DBs

GO:

0004383

Genes

HSA:	4882(NPR2)

PTR:	465084(NPR2)

PPS:	100991030(NPR2)

GGO:	101145840(NPR2)

PON:	100437411(NPR2)

PPYG:

129044231(NPR2)

NLE:	100595720(NPR2)

HMH:	116475070(NPR2)

SSYN:

129490179(NPR2)

MCC:	695750(NPR2)

MCF:	102136908(NPR2)

MTHB:

126938027

MNI:	105485740(NPR2)

CSAB:

103219213(NPR2)

CATY:

105598126(NPR2)

PANU:

101017565(NPR2)

TGE:	112608499(NPR2)

MLEU:

105539718(NPR2)

RRO:	104672382(NPR2)

RBB:	108518991(NPR2)

TFN:	117099002(NPR2)

PTEH:

111536756(NPR2)

CANG:

105509898(NPR2)

CJC:	100410630(NPR2)

SBQ:	101049666(NPR2)

CIMI:

108314249(NPR2)

ANAN:

105724597(NPR2)

CSYR:

103265460(NPR2)

MMUR:

105874299(NPR2)

LCAT:

123646150(NPR2)

PCOQ:

105820612(NPR2)

OGA:	100944781(NPR2)

MMU:	230103(Npr2)

MCAL:

110292276(Npr2)

MPAH:

110338739(Npr2)

RNO:	116564(Npr2)

MCOC:

116095906(Npr2)

ANU:	117708437(Npr2)

ASYL:

127680721(Npr2)

MUN:	110561887(Npr2)

CGE:	100772356(Npr2)

MAUA:

101830535(Npr2)

PROB:

127224602(Npr2)

PLEU:

114703201(Npr2)

MORG:

121458452(Npr2)

MFOT:

126509819

AAMP:

119826330(Npr2)

NGI:	103741534(Npr2)

HGL:	101712380(Npr2)

CPOC:

100732021(Npr2)

CCAN:

109693375(Npr2)

DORD:

105993342(Npr2)

DSP:	122122409(Npr2)

PLOP:

125340154(Npr2)

NCAR:

124964609

MMMA:

107147801(Npr2)

ITI:	101955295(Npr2)

OCU:

100356598

OPI:	101532437(NPR2)

TUP:	102502023(NPR2)

GVR:	103594561(NPR2)

CFA:	474762(NPR2)

CLUD:

112649906(NPR2)

VVP:	112930835(NPR2)

VLG:	121494419(NPR2)

NPO:	129495053(NPR2)

AML:	100472601(NPR2)

UMR:	103667090(NPR2)

UAH:	113260460(NPR2)

UAR:	123780997(NPR2)

ELK:

111146108

LLV:

125083944

MPUF:

101687306(NPR2)

MNP:	132024613(NPR2)

MLK:	131812768(NPR2)

NVS:	122917476(NPR2)

ORO:	101385033(NPR2)

EJU:	114202844 114218250(NPR2)

ZCA:	113934233(NPR2)

MLX:	118017958(NPR2)

NSU:	110581869(NPR2)

LWW:	102743744(NPR2)

FCA:	101094301(NPR2)

PYU:	121034652(NPR2)

PCOO:

112859633(NPR2)

PBG:	122474943(NPR2)

PVIV:

125150004(NPR2)

LRUF:

124526032

LGF:	123593470(NPR2)

AJU:

106981295

PTG:	102949070(NPR2)

PPAD:

109270151(NPR2)

PUC:

125919466

PLEZ:

122205216(NPR2)

HHV:	120221304(NPR2)

BTA:	281357(NPR2)

BOM:	102278070(NPR2)

BIU:	109563021(NPR2)

BBUB:

102398513(NPR2)

BBIS:

104993006(NPR2)

CHX:	100861577(NPR2)

OAS:	101112950(NPR2)

BTAX:

128052824(NPR2)

CSUM:

138081463(NPR2)

ODA:	120881127(NPR2)

CCAD:

122453024(NPR2)

MREE:

136148285(NPR2)

OVR:	110129194(NPR2)

MBEZ:

129556801(NPR2)

SSC:	100512698(NPR2)

CFR:	102507709(NPR2)

CBAI:

105067337(NPR2)

CDK:	105102284(NPR2)

VPC:	102541120(NPR2)

BACU:

103002831(NPR2)

BMUS:

118896671(NPR2)

LVE:	103087466(NPR2)

OOR:	101273275(NPR2)

LALB:

132523535(NPR2)

DLE:	111187995(NPR2)

PCAD:

102991665(NPR2)

PSIU:

116755736(NPR2)

NASI:

112411735(NPR2)

ECB:	100055416(NPR2)

EPZ:	103541278(NPR2)

EAI:	106846972(NPR2)

MYB:	102238967(NPR2)

MYD:	102771508(NPR2)

MMYO:

118667331(NPR2)

MLF:	102425391(NPR2)

MDT:	132212127(NPR2)

MYUM:

139021056(NPR2)

PKL:	118716320(NPR2)

EFUS:

103286438(NPR2)

MNA:	107544941(NPR2)

DRO:	112304548(NPR2)

SHON:

118979786(NPR2)

AJM:	119048744(NPR2)

PDIC:

114493137(NPR2)

PHAS:

123820025(NPR2)

MMF:	118629513(NPR2)

PPAM:

129079425(NPR2)

HAI:	109393761(NPR2)

RFQ:	117032145(NPR2)

PALE:

102885265(NPR2)

PGIG:

120612856(NPR2)

PVP:	105306470(NPR2)

RAY:	107502774(NPR2)

MJV:	108406538(NPR2)

TOD:	119230526(NPR2)

SARA:

101551968(NPR2)

SFUM:

130026321(NPR2)

SETR:

126008796(NPR2)

LAV:	100676492(NPR2)

TMU:

101351573

ETF:	101656005(NPR2)

DNM:	101411447(NPR2)

MDO:	100020156(NPR2) 100024379

GAS:	123232409(NPR2) 123250226

SHR:	100932333(NPR2)

AFZ:

127540311

PCW:	110200851 110201433(NPR2)

TVP:	118831168 118831308(NPR2)

PBRV:

138162055(NPR2)

OAA:	100078016 100087666(NPR2)

TACU:

119922887(NPR2) 119947870

GGA:	100859339(NPR2) 431640(NPR1)

PCOC:

116239692(NPR2) 116239745

MGP:	100539537(NPR2)

CJO:	107305835(NPR2) 107306595

TPAI:

128074445(NPR2) 128089668

LMUT:

125687083(NPR2) 125687414

NMEL:

110389689(NPR2) 110390071

APLA:

101791898(NPR2) 101804639

ACYG:

106036311(NPR2) 106043048

CATA:

118256693(NPR2) 118257031

AFUL:

116500975 116501143(NPR2)

TGU:	100227153(NPR2)

LSR:	110467768 110484218(NPR2)

SCAN:

103821848 103822923

PMOA:

120502459(NPR2) 120513655

OTC:	121333652 121337362(NPR2)

PRUF:

121355518(NPR2) 121363723

ATRC:

139589311(NPR2) 139589379

GFR:	102039158(NPR2) 102041232

FAB:	101807229(NPR2) 101821431

OMA:	130264911(NPR2) 130265444

PHI:	102099290 102105257(NPR2)

PMAJ:

107198475(NPR2) 107215797

CCAE:

111940997(NPR2) 111941232

CCW:	104686575(NPR2) 104690483

CBRC:

103611656 103611848(NPR2)

ACOE:

138103328(NPR2) 138103877

ETL:	114068670 114069707(NPR2)

ZAB:	102063860 102070321(NPR2)

ZLE:	135459430(NPR2) 135460126

ACHL:

103807038

SVG:	106852747(NPR2) 106857798

MMEA:

130572931 130575595(NPR2)

HRT:	120765621(NPR2)

SATI:

136374264 136374656(NPR2)

CCIC:

134056302(NPR2) 134056922

FPG:	101916740(NPR2) 101920659

FCH:	102051925(NPR2)

CCRI:

104160307

NNT:	104401798 104410094

SHAB:

115601023

ACUN:

113489899(NPR2) 113490203

TALA:

104357822 116964697

ACHC:

115336875

HALD:

104323182

HLE:	104833289(NPR2) 104838440

AGEN:

126035799 126036289

HHAR:

128137353 128137458(NPR2)

GCL:

127027225

CSTI:

104552766

LDI:	104342003 104343776

MNB:	103775306 103779226

DPUB:

104301730 104304840(NPR2)

PPUS:

135173385(NPR2) 135193138

AVIT:

104271367(NPR2)

BRHI:

104492009 104495986

EGZ:	104123036 104133897(NPR2)

NNI:

104019848

PCRI:

104031031

PCAO:

104041478

PADL:

103917675(NPR2) 103921085

AFOR:

103903928(NPR2) 103904749

FGA:

104082688

GSTE:

104260289

CLV:	102088233 102098846(NPR2)

MUI:

PGUU:

PLET:

CMAC:

CUCA:

104056593(NPR2) 104059653

TEO:	104373225 104374717

BREG:

104630379 104641189

OHA:

104338373

ACAR:

104526779

CPEA:

104393440 104398656(NPR2)

CVF:

104296055

RTD:	128902672 128902984(NPR2)

CRID:

134508446 134508794(NPR2)

AAM:	106493342(NPR2)

AROW:

112963994 112976231(NPR2)

NPD:	112952187(NPR2)

TGT:	104574262 104575503

DNE:	112993378 112993621(NPR2)

SCAM:

104145312

ASN:	102368327(NPR2) 102369559

AMJ:

CPOO:

GGN:

PSS:

CMY:	102933143(NPR2) 102937891

CCAY:

125629286(NPR2) 125637219

DCC:	119856143(NPR2) 119856320

CPIC:

101939273

TST:	117879256 117886480(NPR2)

CABI:

116816745(NPR2) 116828369

MRV:	120407255 120408252(NPR2)

ACS:	100566773 100568215(npr2)

ASAO:

132766793(NPR2) 132767483

PVT:	110082828(NPR2)

SUND:

121920536 121922325(NPR2)

PBI:	103052637(NPR2) 103054566

PMUR:

107295817 107299286(NPR2)

CTIG:

120308027 120319793(NPR2)

TSR:	106538512 106546673

PGUT:

117661929 117679722(NPR2)

APRI:

131190683 131192916(NPR2)

PTEX:

113444610 113449682(NPR2)

NSS:	113415038 113423509(NPR2)

VKO:	123022423 123030191(NPR2)

PMUA:

114588050 114606224(NPR2)

PRAF:

128405339 128423595(NPR2)

ZVI:	118075244 118077145(NPR2)

HCG:	128346587(NPR2) 128347892

GJA:	107110597(NPR2) 107111853 107114522

STOW:

125425380 125436516(NPR2) 125437021

EMC:	129334333(NPR2) 129335169

XLA:	108705075(npr2.S) 108713520 399350(npr2.L)

XTR:	100488543(npr2) 101732477

NPR:	108791371 108803575

RTEM:

120922123(NPR2) 120946239

BBUF:

120979859 120990897 120991911(NPR2)

BGAR:

122924041(NPR2) 122927542 122944136

PWL:	138251987(NPR2) 138293926

MUO:	115461921 115462792(NPR2) 115472439

GSH:	117356968(NPR2) 117368913

DRE:	100331745(npr2)

SRX:	107715696 107730344 107746469

SANH:

107655354 107664813 107683705 107684353 107702147

SGH:	107559735 107563522 107595992

CCAR:

109088458 109088462 109112390

CAUA:

113039920 113049852 113083596 113088746

CGIB:

127944352 127958866 127986885 127993367

PTET:

122327107 122334540 122345054(npr2)

LROH:

127154044 127154770 127165737(npr2)

OMC:	131531017 131532500 131540722(npr2)

PPRM:

120471886 120477207 120484099

RKG:	130071143(npr2) 130071741

MAMB:

125252665 125260715 125268014(npr2)

CIDE:

127505467 127512705 127520401

CERY:

137008821 137028142 137034359(npr2)

MASI:

127420270 127424226 127433789 127438887

TROS:

130545049 130548973 130566761(npr2)

TDW:	130408879 130418920(npr2)

MANU:

129430924 129441171(npr2)

PDAB:

135764994 135774452(npr2)

IPU:	108260050 108271041 108275604

IFU:	128603392(npr2) 128613912 128619429

PHYP:

113531491(npr2) 113533698

SMEO:

124379092(npr2) 124391330 124398975

TFD:	113641271(npr2) 113652989 113658961

TVC:	132840698(npr2) 132841639 132862203

CGAR:

128510873 128512189(npr2) 128543209

NGRA:

132875756(npr2) 132895920 132899048

TRN:	134303717(npr2)

AMEX:

103046191 103046823 103047846(npr2)

CMAO:

118814564

EEE:	113588239(npr2)

CHAR:

105891429 105898241 105913097

SPIL:

134060462 134100564(npr2) 134101624

TRU:	101062945 101072951 101074483

TFS:	130517713(npr2) 130523309 130528136

TNG:	GSTEN00009255G001

LCO:	104922886 104931951

NCC:	104954259 104967923

TBEN:

117479053 117480799 117495181

CGOB:

115006970 115016547

PGEO:

117440612 117445549 117456328(npr2)

GACU:

117555167 117558806

EMAC:

134868164(npr2) 134869753 134876297

ELY:	117245826 117254290 117269449

EFO:	125884281 125896239 125905778(npr2)

PLEP:

121959522 121963470 121966457

SLUC:

116034786 116055182 116064516

ECRA:

117950629 117959793

ESP:	116696126 116704376(npr2)

PFLV:

114546121 114561657 114571298(npr2)

GAT:	120813226 120823940 120832183

PPUG:

119216162 119221733 119226925(npr2)

AFB:	129093795 129094730 129102151(npr2)

CLUM:

117729402 117740420 117747915

PSWI:

130194232 130204993(npr2) 130212109

CANA:

137784212(npr2) 137792529 137794610

CVE:	137870590 137874443 137888922(npr2)

MSAM:

119900644 119911590 119915036

SCHU:

122866004(npr2) 122870325 122877875

CUD:	121504373 121512238 121525691

SPUL:

138600507 138605113(npr2) 138607985

LMIX:

132958790 132964426 132991975(npr2)

ALAT:

119026690 119029134 119030332

ASTR:

137590937 137598788 137608040(npr2)

MZE:	101476270 101476620

ONL:	100699775 100699899

OAU:	116324894 116335898

OLA:	100049174(olgc8) 100049183(npr2)

OML:	112156508 112163198

CSAI:

133420942 133455440(npr2)

XMA:	102226281(npr2) 102226340

XCO:	114149767 114157660

XHE:	116724463(npr2) 116732660

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122820801 122846990(npr2)

PPRL:

129366401 129379582

CVG:	107083749(npr2) 107099068

CTUL:

119773772 119785164

GMU:	124872538(npr2) 124881291

NFU:	107375102 107396738

KMR:	108228472 108249273

ALIM:

106527639 106536042

NWH:	119417381 119424915

AOCE:

111579687 111581446(npr2) 111586261

EJA:	138198551 138205337(npr2) 138214149

BFRE:

138618768 138625110(npr2) 138636398

MCEP:

124996591(npr2) 125009554 125022294 125022640

CSEM:

103389042 103390085 103393289

POV:	109625491 109634791 109640907(npr2)

SSEN:

122758453(npr2) 122766253 122780508

SSOE:

131446527(npr2) 131456318 131465854

HHIP:

117751838 117759913 117771235

HSP:	118102983 118121275 118125952(npr2)

PPLT:

128424889 128430574 128448010

SMAU:

118285587(npr2) 118318706 118319861

LCF:	108881285 108889017 108892359

SDU:	111221111(npr2) 111233148 111233435

SLAL:

111650128 111650201 111661037

XGL:	120790737 120797313 120806656

HCQ:	109506964 109522044 109527094

SSCV:

125969446 125979194(npr2) 125987881

SBIA:

133494949 133503517 133515239(npr2)

PEE:	133398106 133406514 133413604(npr2)

PTAO:

133472755 133480728 133489953(npr2)

BPEC:

110160033 110170298 110170490

ENY:	140353580 140367109(npr2) 140371530

MALB:

109968674 109972946

BSPL:

114851238 114866701(npr2)

SJO:	128362233 128380783(npr2) 128383653

SSCO:

133985205 133995002(npr2) 134006269

GMH:	115529974 115541575 115555767 115561195

SASA:

106563312 106566722 106613447

STRU:

115157926 115159593 115195009 115204045

OTW:	112217310 112220406 112230963 112239300

OMY:	100136307 110521960 110523562 118948717

OGO:	123994957 124007128 124008824 124048988

ONE:	115101146 115122400 115140427

OKI:	109866679 109867948 109873703

OKE:	118385326 118387512 127927435

OMM:	135518007 135534110 135534260 135544492 135557355

OCLA:

139388550 139407997 139408612 139417010

SALP:

111961636 111962951 111963996

SNH:	120021235 120025760 120037992 120054588

CCLU:

121533791 121541649 121582527 123482874

ELS:	105006247 105015043(npr2)

OEP:	134009527 134011141 134038470(npr2)

SFM:	108926017 108929872(npr2)

PKI:	111835585(npr2) 111859280 111860506

AANG:

118213044 118225167 118232595

AROT:

135239261(npr2) 135253753 135258658

CCOG:

133126780 133135915 133142118(npr2)

LOC:	102685925 102692626 102696239

PSPA:

121301817 121315978 121323913 121326529 121330699

ARUT:

117409059 117409117 117411105 117416441 117420438 117963557 117970475

PSEX:

120514322 120532065 120532921

LCM:	102366518 102367462

CMK:	103174800 103181010 103187223

RTP:	109926963 109927210(npr2)

CPLA:

122539383 122548373(npr2) 122554107

HOC:	132807024(npr2) 132818565 132826044

LERI:

129695485 129695828(npr2) 129701297

PMRN:

116951912 116952098

LRJ:

133350435

BFO:

118432137

BBEL:

109465960 109471369 109474004 109477830 109486256

SPU:	100889870 100893963

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

140137680 140140650 140141496 140143424

PFLL:

FOC:

MRJ:

HAZT:

SDM:

LPOL:

PMEO:

129583417 129584713 129585679 129586663 129587570 129588285 129588645 129590495 129590589 129590651 129592181 129592591 129594913 129594922 129595029 129596647 129599567 129600074 129602728

HRO:	HELRODRAFT_77557 HELRODRAFT_78187

LGI:	LOTGIDRAFT_104429

PVUL:

126824266 126825312 126825377

PCAN:

112560561

LSAX:

138954242 138966471 138967747 138971874

BGT:	106066187 106067796 106079815

GAE:	121368659 121374438 121381601 121382143

HRF:	124134290 124141955 124149776 124149802

HRJ:	124260410 124261388 124267664 124267700 124275225

HASI:

137261215 137291554 137297785 137298592

HCRA:

139461710 139480046

CRG:	105331377 105331903 105346387

CANU:

128164569 128168253 128189434 128190050

CVN:	111099055 111114219 111120350 111120351 111138415

OED:	125666393 125669231

MYI:

110448546

PMAX:

117325107 117326201 117333390 117335512

AIRR:

138325261 138325764 138331440

MCAF:

127733868 127739018

MMER:

123523529 123524906 123535987 123537183

RPHI:

132718858 132728135 132730354 132753708 132754954 132756528

DPOL:

127861597 127861598 127861695 127861951 127864494

MAEA:

128213315 128214186 128214643 128214826

LLON:

135486800 135487128 135487770 135501296

ADF:

107357160

TAD:	TRIADDRAFT_59364

» show all

Reference

PMID:10082481

Authors

Rehemudula D, Nakayama T, Soma M, Takahashi Y, Uwabo J, Sato M, Izumi Y, Kanmatsuse K, Ozawa Y

Title

Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension.

Journal

Circ Res 84:605-10 (1999)
DOI:10.1161/01.res.84.5.605

Sequence

[hsa:4882]

LinkDB

DBGET integrated database retrieval system