KEGG   DRUG: Vonlerolizumab
Entry
D11268                      Drug                                   
Name
Vonlerolizumab (USAN/INN);
Pogalizumab
Formula
C6444H9976N1716O2024S44
Exact mass
145191.8158
Mol weight
145281.303
Sequence
(Heavy chain)
EVQLVQSGAE VKKPGASVKV SCKASGYTFT DSYMSWVRQA PGQGLEWIGD MYPDNGDSSY
NQKFRERVTI TRDTSTSTAY LELSSLRSED TAVYYCVLAP RWYFSVWGQG TLVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKKVEPKSC DKTHTCPPCP APELLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQDIS NYLNWYQQKP GKAPKLLIYY TSRLRSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GHTLPPTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H144-H200, H220-L214, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'96, H'144-H'200, H'220-L'214, H'261-H'321, H'367-H'425, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Anti-CD134 antibody
Comment
Monoclonal antibody
Target
TNFRSF4 (CD134, OX40) [HSA:7293] [KO:K05142]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF4 (CD134, OX40)
     D11268  Vonlerolizumab (USAN/INN)
Other DBs
CAS: 1638935-72-4
PubChem: 384585246
LinkDB

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