KEGG   DRUG: Duvortuxizumab
Entry
D11372                      Drug                                   

Name
Duvortuxizumab (USAN)
Formula
C4850H7485N1305O1487S35
Exact mass
108921.0425
Mol weight
108988.4522
Sequence
(A chain)
ENVLTQSPAT LSVTPGEKAT ITCRASQSVS YMHWYQQKPG QAPRLLIYDA SNRASGVPSR
FSGSGSGTDH TLTISSLEAE DAATYYCFQG SVYPFTFGQG TKLEIKGGGS GGGGEVQLVE
SGGGLVQPGG SLRLSCAASG FTFSTYAMNW VRQAPGKGLE WVGRIRSKYN NYATYYADSV
KGRFTISRDD SKNSLYLQMN SLKTEDTAVY YCVRHGNFGN SYVSWFAYWG QGTLVTVSSA
STKGEVAACE KEVAALEKEV AALEKEVAAL EKGGGDKTHT CPPCPAPEAA GGPSVFLFPP
KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV
LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL
WCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC
SVMHEALHNH YTQKSLSLSP GK
(B chain)
QAVVTQEPSL TVSPGGTVTL TCRSSTGAVT TSNYANWVQQ KPGQAPRGLI GGTNKRAPWT
PARFSGSLLG GKAALTITGA QAEDEADYYC ALWYSNLWVF GGGTKLTVLG GGGSGGGGQV
TLRESGPALV KPTQTLTLTC TFSGFSLSTS GMGVGWIRQP PGKALEWLAH IWWDDDKRYN
PALKSRLTIS KDTSKNQVFL TMTNMDPVDT ATYYCARMEL WSYYFDYWGQ GTTVTVSSAS
TKGKVAACKE KVAALKEKVA ALKEKVAALK E
(C chain)
DKTHTCPPCP APEAAGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD
GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK
GQPREPQVYT LPPSREEMTK NQVSLSCAVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLVSKL TVDKSRWQQG NVFSCSVMHE ALHNRYTQKS LSLSPG
(Disulfide bridge: A23-A87, A136-A212, A249-B248, A281-C6, A284-C9, A316-A376, A422-A481, B22-B90, B140-B215, C41-C101, C147-C205)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Treatment of B-cell malignancies
Target
CD19 [HSA:930] [KO:K06465]
CD3E [HSA:916] [KO:K06451]
  Pathway
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3E
     D11372  Duvortuxizumab (USAN)
    CD19
     D11372  Duvortuxizumab (USAN)
Other DBs
CAS: 1831098-91-9
PubChem: 384585350
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system