KEGG ORTHOLOGY: K06451

ORTHOLOGY: K06451

Entry

K06451                      KO

Symbol

CD3E

Name

T-cell surface glycoprotein CD3 epsilon chain

Pathway

map04640

Hematopoietic cell lineage

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05142

Chagas disease

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04660 T cell receptor signaling pathway
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04658 Th1 and Th2 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04659 Th17 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05170 Human immunodeficiency virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05162 Measles
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05169 Epstein-Barr virus infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
CD molecules [BR:ko04090]
Proteins
  K06451  CD3e; CD3E antigen, epsilon polypeptide (TiT3 complex)

Genes

HSA:

916(CD3E)

PTR:	742330(CD3E)

PPS:

GGO:

PON:

PPYG:

NLE:	100582516(CD3E)

HMH:

116477006

SSYN:

129479735

MCC:	699467(CD3E)

MCF:

102133065

MTHB:

126936068

MNI:	105476414(CD3E)

CSAB:

103248584(CD3E)

CATY:

105582468(CD3E)

PANU:

101017085(CD3E)

TGE:	112606383(CD3E)

MLEU:

105528216(CD3E)

RRO:	104665572(CD3E)

RBB:	108536387(CD3E)

TFN:	117080881(CD3E)

PTEH:

111540204(CD3E)

CANG:

105501091(CD3E)

CJC:	100403944(CD3E)

SBQ:	101030803(CD3E)

CIMI:

108300594(CD3E)

ANAN:

105729557

CSYR:

103252367(CD3E)

MMUR:

105876056(CD3E)

LCAT:

123641521(CD3E)

PCOQ:

105819243(CD3E)

OGA:	100966596(CD3E)

MMU:	12501(Cd3e)

MCAL:

110302127(Cd3e)

MPAH:

110328560(Cd3e)

RNO:	315609(Cd3e)

MCOC:

116073337(Cd3e)

ANU:	117699427(Cd3e)

MUN:

110549111

CGE:	100757488(Cd3e)

MAUA:

101836794(Cd3e)

PROB:

127231638

PLEU:

114691295(Cd3e)

MORG:

121438262(Cd3e)

MFOT:

126510033

AAMP:

119810074(Cd3e)

NGI:	103728619(Cd3e)

HGL:	101711464(Cd3e)

CPOC:

100727781(Cd3e)

CCAN:

109684407(Cd3e)

DORD:

105980885(Cd3e)

DSP:	122110413(Cd3e)

PLOP:

125347803

NCAR:

124959811

MMMA:

107145811

OCU:	100008616(CD3E) 100339529

OPI:	101521312(CD3E)

TUP:	102499022(CD3E)

GVR:	103592268(CD3E)

CFA:	442981(CD3E)

CLUD:

112671249

VVP:	112920227(CD3E)

VLG:	121499400(CD3E)

NPO:

129497000

AML:	100482462(CD3E)

UMR:	103662338(CD3E)

UAH:

113260003

UAR:	123792617(CD3E)

ELK:

111153962

LLV:

125079621

MPUF:

101676091(CD3E)

MNP:

132027477

MLK:

131836598

NVS:	122912333(CD3E)

ORO:	101385667(CD3E)

EJU:	114211298(CD3E)

ZCA:	113913757(CD3E)

MLX:	118013285(CD3E)

NSU:	110586253(CD3E)

LWW:	102729553(CD3E)

FCA:	493936(CD3E)

PYU:	121035463(CD3E)

PCOO:

112865851(CD3E)

PBG:	122483024(CD3E)

PVIV:

125176523

LRUF:

124504771

PTG:	102969557(CD3E)

PPAD:

109278561(CD3E)

PUC:

125909427

AJU:

106966166

HHV:	120229941(CD3E)

BTA:	281054(CD3E)

BOM:	102272861(CD3E)

BIU:	109569940(CD3E)

BBUB:

102390460(CD3E)

BBIS:

104981364(CD3E)

CHX:	102190711(CD3E)

OAS:	443437(CD3E)

BTAX:

128060834

CSUM:

138093145(CD3E)

ODA:	120876318(CD3E)

CCAD:

122450228(CD3E)

MREE:

136174709(CD3E)

MBEZ:

129553777

SSC:	397455(CD3E)

CFR:	102518964(CD3E)

CBAI:

105067821(CD3E)

CDK:	105090174(CD3E)

VPC:	102542709(CD3E)

BACU:

103003476(CD3E)

BMUS:

118899674(CD3E)

LVE:	103070290(CD3E)

OOR:

101279986

DLE:	111166898(CD3E)

PCAD:

102979279

PSIU:

116758072(CD3E)

NASI:

112404002(CD3E)

ECB:	100629532(CD3E)

EPZ:	103546676(CD3E)

EAI:	106840276(CD3E)

MYB:	102240865(CD3E)

MYD:	102753033(CD3E)

MMYO:

118664241(CD3E)

MLF:	102438976(CD3E)

MDT:

132240485

PKL:	118710580(CD3E)

EFUS:

103293819

MNA:	107530780(CD3E)

DRO:	112314382(CD3E)

SHON:

118994765(CD3E)

AJM:	119050802(CD3E)

PDIC:

114499775(CD3E)

PHAS:

123818673(CD3E)

MMF:	118628023(CD3E)

PPAM:

129086043

HAI:	109385284(CD3E)

RFQ:	117030447(CD3E)

PALE:

102894744(CD3E)

PGIG:

120622048(CD3E)

PVP:	105309263(CD3E)

RAY:	107516045(CD3E)

MJV:	108385087(CD3E)

TOD:

119239887

SARA:

101545393(CD3E)

SETR:

126015614

LAV:	100654724(CD3E)

TMU:

101359660

ETF:	101656529(CD3E)

DNM:	101421796(CD3E)

MDO:	100031478(CD3E)

GAS:	123239093(CD3E)

SHR:	100919058(CD3E)

PCW:	110207187(CD3E)

TVP:	118840025(CD3E)

PBRV:

138145000(CD3E)

OAA:	103164647(CD3E)

GGA:	396062(CD3E)

PCOC:

116233174(CD3E)

MGP:	100542967(CD3E)

CJO:	107324151(CD3E)

TPAI:

128087673

LMUT:

125703730

NMEL:

110387607(CD3E)

APLA:

101792798(CD3E)

ACYG:

106039831(CD3E)

CATA:

118252428

AFUL:

116497933(CD3E)

TGU:	115498349(CD3E)

LSR:	110470447(CD3E)

SCAN:

103822978(CD3E)

PMOA:

120508488(CD3E)

OTC:	121340848(CD3E)

PRUF:

121348513(CD3E)

GFR:	102033069(CD3E)

FAB:	101805814(CD3E)

OMA:

130262469

PHI:	102100748(CD3E)

PMAJ:

107214303(CD3E)

CCAE:

111939275(CD3E)

CCW:	104692070(CD3E)

CBRC:

103618515(CD3E)

ACOE:

138098275(CD3E)

ETL:	114056274(CD3E)

ZAB:	102074438(CD3E)

ZLE:

135457453

ACHL:

103806925(CD3E)

SVG:	106858160(CD3E)

MMEA:

130583274

HRT:

120762480

SATI:

136370930 136371122(CD3E)

FPG:	101916374(CD3E)

FCH:	102052256(CD3E)

CCRI:

104156647(CD3E)

NNT:	104408028(CD3E)

SHAB:

115616384(CD3E)

ACUN:

113488553(CD3E)

TALA:

104362678(CD3E)

ACHC:

115344580(CD3E)

HALD:

104312091(CD3E)

HLE:	104836396(CD3E)

AGEN:

126038199

HHAR:

128141648

GCL:

127025857

CSTI:

104551755(CD3E)

LDI:	104354386(CD3E)

MNB:	103774582(CD3E)

DPUB:

104299250(CD3E)

PPUS:

135191045

AVIT:

104270070(CD3E)

BRHI:

104497095(CD3E)

EGZ:	104124563(CD3E)

NNI:	104019038(CD3E)

PCRI:

104037965(CD3E)

PCAO:

104041594(CD3E)

PADL:

103921537(CD3E)

AFOR:

103894944(CD3E)

FGA:	104073433(CD3E)

GSTE:

104260226(CD3E)

CLV:	102092091(CD3E)

MUI:	104535368(CD3E)

PGUU:

104462627(CD3E)

PLET:

104623865(CD3E)

EHS:	104508131(CD3E)

CMAC:

104485275(CD3E)

CUCA:

104068840

TEO:	104373114(CD3E)

BREG:

104631275(CD3E)

OHA:	104331957(CD3E)

ACAR:

104521636(CD3E)

CVF:	104295025(CD3E)

RTD:

128918573

AAM:	106491550(CD3E)

AROW:

112962095(CD3E)

NPD:	112948116(CD3E)

TGT:	104569302(CD3E)

DNE:	112991722(CD3E)

SCAM:

104151775(CD3E)

ASN:	102385481(CD3E)

AMJ:	102572715(CD3E)

CPOO:

109315402(CD3E)

GGN:	109293882(CD3E)

PSS:	102444605(CD3E)

CMY:	102940609(CD3E)

CCAY:

125625460

DCC:	119846657(CD3E)

CPIC:

101932898(CD3E)

TST:	117868714(CD3E)

CABI:

116822955(CD3E)

MRV:	120375881(CD3E)

ACS:	103281392(cd3e)

ASAO:

132782469

PVT:	110079214(CD3E)

PBI:	103063950(CD3E)

PMUR:

107284819(CD3E)

CTIG:

120307253(CD3E)

TSR:	106540658(CD3E)

PGUT:

117670185

APRI:

131203942

PTEX:

113441828(CD3E)

NSS:	113420881(CD3E)

VKO:	123020252(CD3E)

PMUA:

114585624(CD3E)

PRAF:

128402758

ZVI:	118097107(CD3E)

HCG:

128333839

STOW:

125442238

XLA:	108696460(cd3e.L) 108697598(cd3e.S)

XTR:	100101735(cd3e)

NPR:	108792155(CD3E)

RTEM:

120916071(CD3E)

BBUF:

120996018(CD3E)

BGAR:

122926772(CD3E)

MUO:	115481598(CD3E)

GSH:	117347846(CD3E)

SRX:	107710512(cd3e) 107757322

SANH:

107677251 107678881 107696790(cd3e)

SGH:	107557646(cd3e) 107575792

CCAR:

109113691(cd3e)

CAUA:

113058827 113058859 113114680

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CERY:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113544469(cd3e)

SMEO:

TFD:

TVC:

TRN:

AMEX:

EEE:	113581196(cd3e)

CHAR:

105911012

TRU:	654301(cd3e)

TFS:

130535526

NCC:	104958452(cd3e)

TBEN:

117470090

CGOB:

115017714(cd3e)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116679175(cd3e)

PFLV:

114552596(cd3e)

GAT:

PPUG:

AFB:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

MZE:	101473479(cd3e)

ONL:	100699580(cd3e)

OAU:

116328965

OML:	112136422 112149932

CSAI:

133442496

XMA:	111612026(cd3e)

XCO:	114162006(cd3e)

XHE:	116707969(cd3e)

PRET:

108166815(cd3e)

PFOR:

103154612 107833469(cd3e)

PLAI:

106942052

PMEI:

106914150 106914157(cd3e)

GAF:	122832286 122832288

PPRL:

129358861

CVG:	107080969 107102557(cd3e)

GMU:	124883953 124883954

NFU:	107372865(cd3e)

KMR:	108244419 108244420

ALIM:

106514964 106514970

NWH:	119411564 119411565

AOCE:

111574529(cd3e)

EJA:

138196890

CSEM:

103377690

POV:	109634477(cd3e)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111232876(cd3e)

SLAL:

111650651(cd3e)

XGL:

120792561

HCQ:	109529377(cd3e)

SBIA:

133504737

PEE:

133405554

PTAO:

133482344

MALB:

109951826(cd3e)

BSPL:

114868718

SJO:

128360868

SASA:

100136516(cd3e)

STRU:

115163129(cd3e)

OTW:

112265197

OMY:	100499597(cd3e)

OGO:

123992953

ONE:	115136973 115142145

OKI:	109905520(cd3e)

OKE:	118384684 118397259

SALP:

111957664 111982584

SNH:

120018799

ELS:	105011076 105011093

SFM:	108932125(cd3e) 108932308

PKI:	111854926 111854957

AANG:

LOC:

PSPA:

ARUT:

LCM:	102349686(CD3E)

RTP:

CPLA:

LERI:

Reference

PMID:3012357

Authors

Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C

Title

Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.

Journal

Nature 321:431-4 (1986)
DOI:10.1038/321431a0

Sequence

[hsa:916]

Reference

PMID:15546002

Authors

de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F

Title

Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.

Journal

J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588

LinkDB

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