| Entry |
|
|---|
| Name |
Naloxone hydrochloride dihydrate |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C19H21NO4. HCl. 2H2O
|
|---|
| Exact mass |
399.1449
|
|---|
| Mol weight |
399.86
|
|---|
| Structure |
|
|---|
| Class |
Analgesic
DG01586 Opioid receptor antagonist
|
|---|
| Remark |
| Product (DG01155): | D01340<JP/US> D11620<US> |
| Product (mixture): | D10250<US> |
|
|---|
| Efficacy |
Narcotic antagonist, Opioid receptor antagonist |
|---|
| Comment |
Normorphine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A06 DRUGS FOR CONSTIPATION
A06A DRUGS FOR CONSTIPATION
A06AH Peripheral opioid receptor antagonists
A06AH04 Naloxone
D11620 Naloxone hydrochloride dihydrate <US>
V VARIOUS
V03 ALL OTHER THERAPEUTIC PRODUCTS
V03A ALL OTHER THERAPEUTIC PRODUCTS
V03AB Antidotes
V03AB15 Naloxone
D11620 Naloxone hydrochloride dihydrate <US>
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG01155 Naloxone
D11620 Naloxone hydrochloride dihydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D11620 Naloxone hydrochloride dihydrate <US>
OPRK1
D11620 Naloxone hydrochloride dihydrate <US>
OPRD1
D11620 Naloxone hydrochloride dihydrate <US>
Drug groups [BR:br08330]
Analgesic
DG01586 Opioid receptor antagonist
DG01155 Naloxone
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 X Cl 23.7264 -16.5177
2 C1z C 16.0276 -16.8674
3 C8y C 16.0276 -15.5376
4 C1z C 17.2174 -17.4974
5 C1y C 14.9077 -17.4274
6 C1x C 17.2174 -16.2375
7 C8y C 14.9077 -14.9077
8 C8y C 17.2174 -14.9077
9 C1y C 18.3372 -16.8674
10 C1x C 17.2174 -18.7572
11 O2x O 13.5779 -16.1676
12 C5x C 14.9077 -18.7572
13 C1x C 19.4571 -16.2375
14 C8y C 14.9077 -13.5779
15 C1x C 18.3372 -15.6076
16 C8x C 17.2174 -13.5779
17 N1y N 19.4571 -17.4974
18 C1x C 16.0276 -19.4571
19 O5x O 13.7879 -19.4571
20 C8x C 16.0976 -12.9480
21 O1a O 13.7879 -12.9480
22 O1a O 18.4772 -18.4072
23 C1b C 20.8568 -17.4974
24 C2b C 21.5567 -18.7572
25 C2a C 22.9565 -18.7572
26 O0 O 24.2200 -14.3500
27 O0 O 24.2200 -12.6700
BOND 28
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1 #Up
5 3 7 2
6 3 8 1
7 4 9 1
8 4 10 1
9 5 11 1 #Down
10 5 12 1
11 6 13 1
12 7 14 1
13 8 15 1
14 8 16 2
15 9 17 1 #Up
16 10 18 1
17 12 19 2
18 14 20 2
19 14 21 1
20 7 11 1
21 9 15 1
22 12 18 1
23 13 17 1
24 16 20 1
25 4 22 1 #Up
26 17 23 1
27 23 24 1
28 24 25 2
|
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