KEGG   DRUG: Lefamulin acetateHelp
Entry
D11632                      Drug                                   

Name
Lefamulin acetate (USAN);
Xenleta (TN)
Formula
C28H45NO5S. C2H4O2
Exact mass
567.323
Mol weight
567.7776
Structure
Mol fileKCF fileDB search
Remark
Chemical structure group: DG03066
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Pleuromutilin [CPD:C09169] derivative
Treatment of community-acquired bacterial pneumonia (CABP)
Target
50S ribosomal subunit
Brite
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11632
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11632
BRITE hierarchy
Other DBs
CAS: 1350636-82-6
ChEMBL: CHEMBL3545309
LinkDB All DBs
KCF data Show

ATOM        39
            1   C1z C    24.5833  -16.8791
            2   C1y C    23.6027  -17.8596
            3   C1y C    24.5833  -15.4784
            4   C1x C    25.8439  -17.5094
            5   C1x C    24.5833  -18.3499
            6   C1z C    22.2020  -17.8596
            7   C5x C    24.2331  -19.1203
            8   C1y C    23.6027  -14.4978
            9   C1a C    25.8439  -14.9180
            10  C1x C    25.5638  -18.9102
            11  C1x C    23.2525  -18.2799
            12  C1y C    21.1514  -16.8791
            13  C1y C    22.1319  -19.2604
            14  C1a C    21.2915  -18.9102
            15  O5x O    23.6027  -20.3810
            16  C1z C    22.2020  -14.4978
            17  O1a O    24.0930  -13.1671
            18  C1x C    21.1514  -15.4784
            19  O7a O    19.8907  -17.3694
            20  C1a C    21.7818  -20.5911
            21  C7a C    18.6301  -16.6690
            22  C1b C    17.4394  -17.3694
            23  O6a O    18.6301  -15.2682
            24  S2a S    16.2488  -16.6690
            25  C1y C    15.0581  -17.3694
            26  C2b C    21.6417  -13.1671
            27  C1a C    20.8012  -14.4978
            28  C2a C    21.6417  -11.8364
            29  C1x C    15.0581  -18.7701
            30  C1x C    13.8675  -19.4705
            31  C1y C    12.6768  -18.7701
            32  C1x C    12.6768  -17.3694
            33  C1y C    13.8675  -16.6690
            34  O1a O    13.8675  -15.2682
            35  N1a N    11.4862  -19.4705
            36  C6a C    29.8200  -18.6900
            37  C1a C    31.0324  -19.3900
            38  O6a O    28.6076  -19.3900
            39  O6a O    29.8200  -17.2900
BOND        41
            1     3   8 1
            2     3   9 1 #Down
            3     4  10 1
            4     5  11 1
            5     6  12 1
            6     6  13 1
            7     6  14 1 #Down
            8     7  15 2
            9     8  16 1
            10    8  17 1 #Up
            11   12  18 1
            12   12  19 1 #Down
            13   13  20 1 #Up
            14   19  21 1
            15   21  22 1
            16   21  23 2
            17   22  24 1
            18    7  10 1
            19   11  13 1
            20   16  18 1
            21   25  24 1 #Down
            22    1   2 1
            23    1   3 1
            24    1   4 1
            25    1   5 1 #Up
            26    2   6 1
            27    2   7 1
            28   16  26 1 #Up
            29   16  27 1 #Down
            30   26  28 2
            31   25  29 1
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   25  33 1
            37   33  34 1 #Up
            38   31  35 1 #Up
            39   36  37 1
            40   36  38 1
            41   36  39 2

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