| Entry |
|
|---|
| Name |
Tolvaptan sodium phosphate (JAN);
Samtasu (TN) |
|---|
| Formula |
C26H24ClN2O6P. 2Na
|
|---|
| Exact mass |
572.0856
|
|---|
| Mol weight |
572.88
|
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| Structure |
|
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| Class |
Cardiovascular agent
DG01506 Arginine vasopressin receptor 2 (AVPR2) antagonist
|
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| Remark |
| Therapeutic category: | 2139 |
| Product (DG03074): | D01213<JP/US> D11659<JP> |
|
|---|
| Efficacy |
Diuretic, Vasopressin V2 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04962 | Vasopressin-regulated water reabsorption |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03X OTHER DIURETICS
C03XA Vasopressin antagonists
C03XA01 Tolvaptan
D11659 Tolvaptan sodium phosphate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
213 Diuretics
2139 Others
D11659 Tolvaptan sodium phosphate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01506 Arginine vasopressin receptor 2 (AVPR2) antagonist
DG03074 Tolvaptan
D11659 Tolvaptan sodium phosphate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Vasopressin
AVPR2
D11659 Tolvaptan sodium phosphate (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D11659
Drug groups [BR:br08330]
Cardiovascular agent
DG01506 Arginine vasopressin receptor 2 (AVPR2) antagonist
DG03074 Tolvaptan
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 38
1 C1x C 12.7280 -16.5743
2 C1x C 11.8888 -15.4554
3 C1x C 12.2384 -14.1266
4 C1y C 13.4972 -13.5672
5 N1y N 14.1266 -16.5743
6 C8y C 14.7560 -14.1966
7 C8y C 15.0358 -15.5253
8 C8x C 16.3645 -15.9449
9 C8x C 17.4135 -15.0358
10 C8y C 17.1338 -13.6371
11 C8x C 15.8051 -13.2175
12 O2b O 13.4972 -12.1685
13 X Cl 18.1828 -12.7280
14 O5a O 14.1266 -19.0220
15 C5a C 14.8260 -17.8331
16 C8y C 16.2247 -17.8331
17 C8y C 16.9240 -19.0220
18 C8x C 18.3227 -19.0220
19 C8y C 19.0220 -17.7632
20 C8x C 18.3227 -16.5743
21 C8x C 16.9240 -16.5743
22 C1a C 16.2247 -20.2109
23 N1b N 20.4906 -17.7632
24 C5a C 21.1900 -16.5743
25 C8y C 22.5886 -16.5743
26 O5a O 20.4906 -15.3854
27 C8y C 23.2880 -17.8331
28 C8x C 24.6866 -17.8331
29 C8x C 25.3860 -16.5743
30 C8x C 24.6866 -15.3854
31 C8x C 23.2880 -15.3854
32 C1a C 22.5886 -19.0220
33 P1b P 13.4972 -10.7685
34 O1c O 13.4972 -9.3685 #-
35 O1c O 12.0972 -10.7685
36 O1c O 14.8972 -10.7685 #-
37 Z Na 17.2900 -10.6400 #+
38 Z Na 16.1000 -9.1000 #+
BOND 39
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 6 11 2
13 4 12 1 #Up
14 10 13 1
15 14 15 2
16 5 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 18 19 2
21 19 20 1
22 20 21 2
23 16 21 1
24 17 22 1
25 19 23 1
26 23 24 1
27 24 25 1
28 24 26 2
29 25 27 2
30 27 28 1
31 28 29 2
32 29 30 1
33 30 31 2
34 25 31 1
35 27 32 1
36 12 33 1
37 33 34 1
38 33 35 2
39 33 36 1
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