KEGG T01001: 554

Homo sapiens (human): 554

Entry

554               CDS       T01001

Symbol

AVPR2, ADHR, DI1, DIR, DIR3, NDI, NDI1, V2R

Name

(RefSeq) arginine vasopressin receptor 2

K04228

arginine vasopressin receptor 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04072

Phospholipase D signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04962

Vasopressin-regulated water reabsorption

Network

nt06325 Hormone/cytokine signaling

Element

N00915

AVP-V2R-PKA signaling pathway

Disease

H00252

Congenital nephrogenic diabetes insipidus

H01294

Nephrogenic syndrome of inappropriate antidiuresis

H01682

Syndrome of inappropriate antidiuretic hormone secretion

H01683

Disorders of antidiuretic hormone (ADH) secretion

Drug target

Conivaptan (DG00276):

D01236 D07748

Desmopressin (DG00497):

D00291 D02235<JP/US>

Lixivaptan:

D04752

Lypressin:

D00366

Mozavaptane hydrochloride:

D01855

Ornipressin:

D07227

Terlipressin (DG00498):

D06672 D08571<US>

Tolvaptan (DG03074):

D01213<JP/US> D11659<JP>

Vasopressin (Argipressin) (DG00496):

D00101<JP/US> D02983 D09820

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    554 (AVPR2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    554 (AVPR2)
   04081 Hormone signaling
    554 (AVPR2)
09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    554 (AVPR2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    554 (AVPR2)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Vasopressin
    554 (AVPR2)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7tm_4 Git3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

X:153902625..153907166

AA seq 371 aa
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS

NT seq 1116 nt +upstreamnt +downstreamnt
atgctcatggcgtccaccacttccgctgtgcctgggcatccctctctgcccagcctgccc
agcaacagcagccaggagaggccactggacacccgggacccgctgctagcccgggcggag
ctggcgctgctctccatagtctttgtggctgtggccctgagcaatggcctggtgctggcg
gccctagctcggcggggccggcggggccactgggcacccatacacgtcttcattggccac
ttgtgcctggccgacctggccgtggctctgttccaagtgctgccccagctggcctggaag
gccaccgaccgcttccgtgggccagatgccctgtgtcgggccgtgaagtatctgcagatg
gtgggcatgtatgcctcctcctacatgatcctggccatgacgctggaccgccaccgtgcc
atctgccgtcccatgctggcgtaccgccatggaagtggggctcactggaaccggccggtg
ctagtggcttgggccttctcgctccttctcagcctgccccagctcttcatcttcgcccag
cgcaacgtggaaggtggcagcggggtcactgactgctgggcctgctttgcggagccctgg
ggccgtcgcacctatgtcacctggattgccctgatggtgttcgtggcacctaccctgggt
atcgccgcctgccaggtgctcatcttccgggagattcatgccagtctggtgccagggcca
tcagagaggcctggggggcgccgcaggggacgccggacaggcagccccggtgagggagcc
cacgtgtcagcagctgtggccaagactgtgaggatgacgctagtgattgtggtcgtctat
gtgctgtgctgggcacccttcttcctggtgcagctgtgggccgcgtgggacccggaggca
cctctggaaggggcgccctttgtgctactcatgttgctggccagcctcaacagctgcacc
aacccctggatctatgcatctttcagcagcagcgtgtcctcagagctgcgaagcttgctc
tgctgtgcccggggacgcaccccacccagcctgggtccccaagatgagtcctgcaccacc
gccagctcctccctggccaaggacacttcatcgtga

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