KEGG   DRUG: Plamotamab
Entry
D11686                      Drug                                   

Name
Plamotamab (USAN/INN)
Formula
C5571H8576N1490O1722S37
Exact mass
125085.8973
Mol weight
125163.0579
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYNMHWVRQA PGQGLEWMGA IYPGNGDTSY
NQKFQGRVTI TADKSISTAY MELSSLRSED TAVYYCARST YYGGDWYFNV WGAGTLVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SDTKVDKKVE PKSCDKTHTC PPCPAPPVAG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVK HEDPEVKFNW YVDGVEVHNA KTKPREEEYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE
MTKNQVSLTC DVSGFYPSDI AVEWESDGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
EQGDVFSCSV MHEALHNHYT QKSLSLSPGK
(Light chain)
QIVLTQSPSS LSASVGDRVT ITCRASSSVS YIHWFQQKPG KSPKPLIYAT SNLASGVPVR
FSGSGSGTDY TLTISSLQPE DFATYYCQQW TSNPPTFGGG TKVEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS TYAMNWVRQA PGKGLEWVGR IRSKYNNYAT
YYADSVKGRF TISRDDSKNT LYLQMNSLRA EDTAVYYCVR HGNFGDSYVS WFAYWGQGTL
VTVSSGKPGS GKPGSGKPGS GKPGSQAVVT QEPSLTVSPG GTVTLTCGSS TGAVTTSNYA
NWVQQKPGKS PRGLIGGTNK RAPGVPARFS GSLLGGKAAL TISGAQPEDE ADYYCALWYS
NHWVFGGGTK LTVLEPKSSD KTHTCPPCPA PPVAGPSVFL FPPKPKDTLM ISRTPEVTCV
VVDVKHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK
VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREQMTKNQ VKLTCLVKGF YPSDIAVEWE
SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS
LSPGK
(Disulfide bridge: H22-H96, H148-H204, H224-L213, H230-h265, H233-h268, H264-H324, H370-H428, L23-L87, L133-L193, h22-h98, h167-h235, h299-h359, h405-h463)
  Type
Peptide
Efficacy
Antineoplastic, Immunomodulator, Anti-CD20 antibody, Anti-CD3 antibody
Comment
Monoclonal antibody
Target
CD20 [HSA:931] [KO:K06466]
CD3E [HSA:916] [KO:K06451]
  Pathway
hsa04640  Hematopoietic cell lineage
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3E
     D11686  Plamotamab (USAN/INN)
    CD20
     D11686  Plamotamab (USAN/INN)
Other DBs
CAS: 2138442-31-4
PubChem: 405226552
LinkDB

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