KEGG   DRUG: Givosiran
Entry
D11702                      Drug                                   
Name
Givosiran (USAN/INN)
Formula
C524H694F16N173O316P43S6
Exact mass
16292.034
Mol weight
16300.3229
Remark
ATC code: A16AX16
Chemical structure group: DG03084
Product (DG03084): D11708<JP/US>
Efficacy
Accumulation reduction (neurotoxic intermediates)
Comment
RNA interference (RNAi) drug
Treatment of acute hepatic porphyria
Target
ALAS1 [HSA:211] [KO:K00643] (mRNA)
  Pathway
hsa00860  Porphyrin metabolism
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX16 Givosiran
      D11702  Givosiran (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Acyltransferases
    ALAS1
     D11702  Givosiran (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11702
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11702
Other DBs
CAS: 1639325-43-1
PubChem: 405226568
LinkDB

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