KEGG   DRUG: GivosiranHelp
Entry
D11702                      Drug                                   

Name
Givosiran (USAN/INN);
Givlaari (TN)
Formula
C524H694F16N173O316P43S6
Exact mass
16292.034
Mol weight
16300.3229
Efficacy
Accumulation reduction (neurotoxic intermediates)
  Disease
Acute hepatic porphyria [DS:H00202]
Comment
RNA interference (RNAi) drug
Treatment of acute hepatic porphyria
Target
ALAS1 [HSA:211] [KO:K00643] (mRNA)
  Pathway
hsa00860  Porphyrin and chlorophyll metabolism
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Acyltransferases
    ALAS1
     D11702  Givosiran (USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11702
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11702
BRITE hierarchy
Other DBs
CAS: 1639325-43-1
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