KEGG   DRUG: Ascrinvacumab
Entry
D11709                      Drug                                   
Name
Ascrinvacumab (USAN/INN)
Formula
C6396H9850N1694O2012S44
Exact mass
143988.8233
Mol weight
144077.6488
Sequence
(Heavy chain)
QVQLQESGPG LVKPSQTLSL TCTVSGGSIS SGEYYWNWIR QHPGKGLEWI GYIYYSGSTY
YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE SVAGFDYWGQ GTLVTVSSAS
TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSNFGTQTYT CNVDHKPSNT KVDKTVERKC CVECPPCPAP PVAGPSVFLF
PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV QFNWYVDGVE VHNAKTKPRE EQFNSTFRVV
SVLTVVHQDW LNGKEYKCKV SNKGLPAPIE KTISKTKGQP REPQVYTLPP SREEMTKNQV
SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPMLDSDGS FFLYSKLTVD KSRWQQGNVF
SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GTSSRATGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYGSSPITFG QGTRLEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H97, H132-L215, H145-H201, H220-H'220, H221-H'221, H224-H'224, H227-H'227, H258-H318, H364-H422, H'22-H'97, H'132-L'215, H'145-H'201, H'258-H'318, H'364-H'422, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Antineoplastic, Anti-activin receptor-like kinase antibody
Comment
Monoclonal antibody
Target
ACVRL1 [HSA:94] [KO:K13594]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor serine/threonine kinases (RSTK)
   TGFBR1 family
    ACVRL1
     D11709  Ascrinvacumab (USAN/INN)
Other DBs
CAS: 1463459-96-2
PubChem: 405226575
LinkDB

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