Homo sapiens (human): 94
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Entry
94 CDS
T01001
Symbol
ACVRL1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
Name
(RefSeq) activin receptor type-1-like isoform 1 precursor
KO
K13594
activin receptor-like kinase 1 [EC:
2.7.11.30
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
Network
nt06507
TGFB signaling
Element
N01426
BMP9/10 signaling pathway
N01462
BMP9/10 signaling pathway, BMP9/10 coreceptor
Disease
H00533
Hereditary hemorrhagic telangiectasia
H01621
Pulmonary arterial hypertension
Drug target
Ascrinvacumab:
D11709
Dalantercept:
D10106
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
94 (ACVRL1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
94 (ACVRL1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.30 receptor protein serine/threonine kinase
94 (ACVRL1)
Protein kinases [BR:
hsa01001
]
Receptor serine/threonine kinases (RSTK): TKL group
TGFBR1 family [OT]
94 (ACVRL1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
TGF_beta_GS
APH
Pkinase_fungal
Motif
Other DBs
NCBI-GeneID:
94
NCBI-ProteinID:
NP_000011
OMIM:
601284
HGNC:
175
Ensembl:
ENSP00000373574.4
UniProt:
P37023
A0A0S2Z310
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:51906944..51923361
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AA seq
503 aa
AA seq
DB search
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
NT seq
1512 nt
NT seq
+upstream
nt +downstream
nt
atgaccttgggctcccccaggaaaggccttctgatgctgctgatggccttggtgacccag
ggagaccctgtgaagccgtctcggggcccgctggtgacctgcacgtgtgagagcccacat
tgcaaggggcctacctgccggggggcctggtgcacagtagtgctggtgcgggaggagggg
aggcacccccaggaacatcggggctgcgggaacttgcacagggagctctgcagggggcgc
cccaccgagttcgtcaaccactactgctgcgacagccacctctgcaaccacaacgtgtcc
ctggtgctggaggccacccaacctccttcggagcagccgggaacagatggccagctggcc
ctgatcctgggccccgtgctggccttgctggccctggtggccctgggtgtcctgggcctg
tggcatgtccgacggaggcaggagaagcagcgtggcctgcacagcgagctgggagagtcc
agtctcatcctgaaagcatctgagcagggcgacagcatgttgggggacctcctggacagt
gactgcaccacagggagtggctcagggctccccttcctggtgcagaggacagtggcacgg
caggttgccttggtggagtgtgtgggaaaaggccgctatggcgaagtgtggcggggcttg
tggcacggtgagagtgtggccgtcaagatcttctcctcgagggatgaacagtcctggttc
cgggagactgagatctataacacagtgttgctcagacacgacaacatcctaggcttcatc
gcctcagacatgacctcccgcaactcgagcacgcagctgtggctcatcacgcactaccac
gagcacggctccctctacgactttctgcagagacagacgctggagccccatctggctctg
aggctagctgtgtccgcggcatgcggcctggcgcacctgcacgtggagatcttcggtaca
cagggcaaaccagccattgcccaccgcgacttcaagagccgcaatgtgctggtcaagagc
aacctgcagtgttgcatcgccgacctgggcctggctgtgatgcactcacagggcagcgat
tacctggacatcggcaacaacccgagagtgggcaccaagcggtacatggcacccgaggtg
ctggacgagcagatccgcacggactgctttgagtcctacaagtggactgacatctgggcc
tttggcctggtgctgtgggagattgcccgccggaccatcgtgaatggcatcgtggaggac
tatagaccacccttctatgatgtggtgcccaatgaccccagctttgaggacatgaagaag
gtggtgtgtgtggatcagcagacccccaccatccctaaccggctggctgcagacccggtc
ctctcaggcctagctcagatgatgcgggagtgctggtacccaaacccctctgcccgactc
accgcgctgcggatcaagaagacactacaaaaaattagcaacagtccagagaagcctaaa
gtgattcaatag
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