KEGG   DRUG: Fisogatinib
Entry
D11737                      Drug                                   
Name
Fisogatinib (USAN/INN)
Formula
C24H24Cl2N4O4
Exact mass
502.1175
Mol weight
503.37
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
FGFR4 [HSA:2264] [KO:K05095]
  Pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    D11737  Fisogatinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR4
     D11737  Fisogatinib (USAN/INN)
Other DBs
CAS: 1707289-21-1
PubChem: 405226603
LinkDB
KCF data

ATOM        34
            1   C8y C    21.6949  -15.4468
            2   C8y C    21.6949  -16.8515
            3   C8y C    22.8889  -17.5539
            4   C8y C    24.1531  -16.8515
            5   C8x C    24.1531  -15.4468
            6   C8y C    22.8889  -14.7444
            7   O2a O    22.8889  -13.3397
            8   C1a C    21.6949  -12.6374
            9   O2a O    25.3471  -17.5539
            10  C1a C    26.5411  -16.8515
            11  X   Cl   22.8889  -18.9586
            12  X   Cl   20.5009  -14.7444
            13  C8y C    20.5009  -17.5539
            14  C8x C    19.3069  -16.8515
            15  C8y C    18.0427  -17.5539
            16  C8y C    18.0427  -18.9586
            17  C8x C    19.2367  -19.6609
            18  C8x C    20.5009  -18.9586
            19  C8x C    16.8487  -16.8515
            20  N5x N    15.6547  -17.5539
            21  C8y C    15.6547  -18.9586
            22  N5x N    16.8487  -19.6609
            23  N1b N    14.4607  -19.6609
            24  C1y C    13.2667  -18.9586
            25  C1y C    13.2667  -17.5539
            26  C1x C    12.0025  -16.8515
            27  C1x C    10.8085  -17.5539
            28  O2x O    10.8085  -18.9586
            29  C1x C    12.0025  -19.6609
            30  N1b N    14.4607  -16.8515
            31  C5a C    14.4607  -15.4468
            32  O5a O    15.6547  -14.7444
            33  C2b C    13.2667  -14.7444
            34  C2a C    12.0635  -15.4266
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 1
            11    3  11 1
            12    1  12 1
            13    2  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   13  18 1
            20   15  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   16  22 1
            25   21  23 1
            26   24  23 1 #Down
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   24  29 1
            33   25  30 1 #Down
            34   30  31 1
            35   31  32 2
            36   31  33 1
            37   33  34 2

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