KEGG   DRUG: Evinacumab
Entry
D11753                      Drug                                   

Name
Evinacumab (USAN/INN);
Evinacumab (genetical recombination) (JAN);
Evinacumab-dgnb;
Evkeeza (TN)
Product
Formula
C6480H9992N1716O2042S46
Exact mass
145991.7936
Mol weight
146081.9345
Sequence
(Heavy chain)
EVQLVESGGG VIQPGGSLRL SCAASGFTFD DYAMNWVRQG PGKGLEWVSA ISGDGGSTYY
ADSVKGRFTI SRDNSKNSLY LQMNSLRAED TAFFYCAKDL RNTIFGVVIP DAFDIWGQGT
MVTVSSASTK GPSVFPLAPC SRSTSESTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTKTYTCN VDHKPSNTKV DKRVESKYGP PCPPCPAPEF
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSQEDPEVQ FNWYVDGVEV HNAKTKPREE
QFNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKGLPSSIEK TISKAKGQPR EPQVYTLPPS
QEEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSRLTVDK
SRWQEGNVFS CSVMHEALHN HYTQKSLSLS LGK
(Light chain)
DIQMTQSPST LSASVGDRVT ITCRASQSIR SWLAWYQQKP GKAPKLLIYK ASSLESGVPS
RFSGSGSGTE FTLTISSLQP DDFATYYCQQ YNSYSYTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H140-L214, H153-H209, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'140-L'214, H'153-H'209, H'267-H'327, H'373-H'431, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Remark
Product: D11753<US>
Efficacy
Antihyperlipidemic, Anti-angiopietin like 3
  Disease
Homozygous familial hypercholesterolemia [DS:H00155]
Comment
Monoclonal antibody
Treatment of dyslipidemia
Target
ANGPTL3 [HSA:27329] [KO:K22288]
  Pathway
hsa04979  Cholesterol metabolism
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Growth factors (RTK-binding)
    ANGPTL3
     D11753  Evinacumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11753
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11753
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11753
Other DBs
CAS: 1446419-85-7
PubChem: 405226619
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system