KEGG   DRUG: Sparsentan
Entry
D11776                      Drug                                   

Name
Sparsentan (USAN/INN)
Formula
C32H40N4O5S
Exact mass
592.2719
Mol weight
592.7488
Structure
Efficacy
Antihypertensive
Comment
Treatment of hypertension
Target
AGTR1 [HSA:185] [KO:K04166]
EDNRA [HSA:1909] [KO:K04197]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D11776  Sparsentan (USAN/INN)
   Endothelin
    EDNRA
     D11776  Sparsentan (USAN/INN)
Other DBs
CAS: 254740-64-2
PubChem: 405226642
ChEMBL: CHEMBL539423
LinkDB
KCF data

ATOM        42
            1   C8y C    14.2100  -12.1100
            2   C8x C    14.2100  -13.5100
            3   C8y C    13.0200  -14.2100
            4   C8y C    11.7600  -13.5100
            5   C8x C    11.7600  -12.1100
            6   C8x C    13.0200  -11.4100
            7   C8y C    10.5700  -14.2100
            8   C8x C    10.5700  -15.6100
            9   C8x C     9.3100  -16.3100
            10  C8x C     8.1200  -15.6100
            11  C8x C     8.1200  -14.2100
            12  C8y C     9.3100  -13.5100
            13  C1b C    13.0200  -15.6100
            14  O2a O    14.2100  -16.3100
            15  C1b C    15.4000  -15.6100
            16  C1a C    16.5900  -16.3100
            17  C1b C    15.4000  -11.4100
            18  N1y N    16.5900  -12.1100
            19  C5x C    16.5900  -13.5100
            20  O5x O    15.4000  -14.2100
            21  S4a S     9.3100  -12.1100
            22  N1b N     8.1200  -11.4100
            23  C8y C     6.9300  -12.1100
            24  N5x N     6.9300  -13.5100
            25  O2x O     5.6700  -14.0000
            26  C8y C     4.7600  -12.8800
            27  C8y C     5.5300  -11.7600
            28  C1a C     5.0400  -10.4300
            29  C1a C     3.3600  -12.9500
            30  C2y C    17.9900  -11.6900
            31  N2x N    18.7600  -12.8100
            32  C1z C    17.9900  -13.9300
            33  C1x C    19.3200  -14.3500
            34  C1x C    19.3200  -15.8200
            35  C1x C    17.9900  -16.2400
            36  C1x C    17.1500  -15.1200
            37  C1b C    18.4800  -10.3600
            38  C1b C    19.8800  -10.0800
            39  C1b C    20.7900  -11.2000
            40  C1a C    22.1900  -10.9200
            41  O3c O     9.3100  -10.7100
            42  O3c O    10.5000  -12.8100
BOND        46
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    3  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18    1  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   12  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 1
            28   26  27 2
            29   23  27 1
            30   27  28 1
            31   26  29 1
            32   18  30 1
            33   30  31 2
            34   31  32 1
            35   19  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   32  36 1
            41   30  37 1
            42   37  38 1
            43   38  39 1
            44   39  40 1
            45   21  41 2
            46   21  42 2

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