KEGG   DRUG: Zuranolone
Entry
D11793                      Drug                                   
Name
Zuranolone (JAN/USAN/INN);
Zurzuvae (TN)
Product
ZURZUVAE (Biogen MA)
Formula
C25H35N3O2
Exact mass
409.2729
Mol weight
409.56
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N06AX31
Product: D11793<JP/US>
Efficacy
Antidepressant, Antiepileptic
Comment
Treatment of postpartum depression
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX31 Zuranolone
      D11793  Zuranolone (JAN/USAN/INN) <US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D11793  Zuranolone (JAN/USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11793  Zuranolone
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D11793  Zuranolone (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11793
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11793
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11793
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11793
Other DBs
CAS: 1632051-40-1
PubChem: 405226659
ChEBI: 228302
LinkDB
KCF data

ATOM        30
            1   C1x C    10.2900  -14.7700
            2   C1z C    10.2900  -16.1700
            3   C1x C    11.5024  -16.8700
            4   C1y C    12.7149  -16.1700
            5   C1y C    12.7149  -14.7700
            6   C1x C    11.5024  -14.0700
            7   C1x C    13.9273  -16.8700
            8   C1x C    15.1397  -16.1700
            9   C1y C    15.1397  -14.7700
            10  C1y C    13.9273  -14.0700
            11  C1y C    16.3522  -14.0700
            12  C1z C    16.3522  -12.6700
            13  C1x C    15.1397  -11.9700
            14  C1x C    13.9273  -12.6700
            15  C1x C    18.7770  -14.0700
            16  C1x C    18.7770  -12.6700
            17  C1y C    17.5646  -11.9700
            18  C5a C    17.5646  -10.5700
            19  C1b C    18.7811   -9.8677
            20  O5a O    16.3562   -9.8723
            21  N4y N    19.9786  -10.5592
            22  C8x C    20.1257  -11.9589
            23  C8y C    21.5024  -12.2515
            24  C8x C    22.2061  -11.0327
            25  N5x N    21.2644   -9.9867
            26  C3b C    22.0692  -13.5246
            27  N3a N    22.7692  -14.7370
            28  C1a C    16.3522  -11.2700
            29  C1a C     8.8900  -16.1700
            30  O1a O     9.5900  -17.3824
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   18  19 1
            23   18  20 2
            24   19  21 1
            25   21  22 1
            26   22  23 2
            27   23  24 1
            28   24  25 2
            29   21  25 1
            30   23  26 1
            31   26  27 3
            32   12  28 1 #Up
            33    2  29 1 #Up
            34    2  30 1 #Down

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