KEGG   DRUG: Clervonafusp alfa
Entry
D11828                      Drug                                   
Name
Clervonafusp alfa (USAN/INN)
Formula
C6586H10059N1759O1975S46
Exact mass
146861.7908
Mol weight
146952.929
Sequence
(Heavy chain)
EVQLQESGGG VVQPGGSLRL SCAASGFTFS NYGMHWIRQA PGKGLEWVSY ISSGSSTIYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRSED TAVYYCARRG LLLDYWGQGT LVTVSSASTK
GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS
LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTGGSGGG SGGGSGGDAQ
AHPGRPRAVP TQCDVPPNSR FDCAPDKAIT QEQCEARGCC YIPAKQGLQG AQMGQPWCFF
PPSYPSYKLE NLSSSEMGYT ATLTRTTPTF FPKDILTLRL DVMMETENRL HFTIKDPANR
RYEVPLETPH VHSRAPSPLY SVEFSEEPFG VIVRRQLDGR VLLNTTVAPL FFADQFLQLS
TSLPSQYITG LAEHLSPLML STSWTRITLW NRDLAPTPGA NLYGSHPFYL ALEDGGSAHG
VFLLNSNAMD VVLQPSPALS WRSTGGILDV YIFLGPEPKS VVQQYLDVVG YPFMPPYWGL
GFHLCRWGYS STAITRQVVE NMTRAHFPLD VQWNDLDYMD SRRDFTFNKD GFRDFPAMVQ
ELHQGGRRYM MIVDPAISSS GPAGSYRPYD EGLRRGVFIT NETGQPLIGK VWPGSTAFPD
FTNPTALAWW EDMVAEFHDQ VPFDGMWIDM NEPSNFIRGS EDGCPNNELE NPPYVPGVVG
GTLQAATICA SSHQFLSTHY NLHNLYGLTE AIASHRALVK ARGTRPFVIS RSTFAGHGRY
AGHWTGDVWS SWEQLASSVP EILQFNLLGV PLVGADVCGF LGNTSEELCV RWTQLGAFYP
FMRNHNSLLS LPQEPYSFSE PAQQAMRKAL TLRYALLPHL YTLFHQAHVA GETVARPLFL
EFPKDSSTWT VDHQLLWGEA LLITPVLQAG KAEVTGYFPL GTWYDLQTVP VEALGSLPPP
PAAPREPAIH SEGQWVTLPA PLDTINVHLR AGYIIPLQGP GLTTTESRQQ PMALAVALTK
GGEARGELFW DDGESLEVLE RGAYTQVIFL ARNNTIVNEL VRVTSEGAGL QLQKVTVLGV
ATAPQQVLSN GVPVSNFTYS PDTKVLDICV SLLMGEQFLV SWC
(Light chain)
DIQMTQSPSS LSASVGDRVT ISCRASKSVS TSSYSYMHWY QQKPEKAPKL LIKYASYLQS
GVPSRFSGSG SGTDFTLTIS SLQPEDVATY YCQHSREFPW TFGAGTKLEL KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H143-H199, H219-L218, H253-H280, H263-H279, H274-H298, H704-H729, H818-H829, H1109-H1123, L23-L92, L138-L198)
  Type
Peptide
Efficacy
Inherited metabolic disorder therapeutic agent
Comment
Fusion protein, enzyme-antibody
Treatment of Pompe disease
Target
GAA [HSA:2548] [KO:K12316]
SLC29A2 (ENT2) [HSA:3177] [KO:K15014]
  Pathway
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa04142  Lysosome
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC29
    SLC29A2 (ENT2)
     D11828  Clervonafusp alfa (USAN/INN)
 Enzymes
  Hydrolases (EC3)
   Glycosidases
    GAA
     D11828  Clervonafusp alfa (USAN/INN)
Other DBs
CAS: 2145123-44-8
PubChem: 405226693
LinkDB

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