KEGG   DRUG: Pavurutamab
Entry
D11992                      Drug                                   
Name
Pavurutamab (USAN)
Formula
C4684H7154N1268O1466S38
Exact mass
105837.3616
Mol weight
105903.0076
Sequence
QVQLVQSGAE VKKPGASVKV SCKASGYTFT NHIIHWVRQA PGQCLEWMGY INPYPGYHAY
NEKFQGRATM TSDTSTSTVY MELSSLRSED TAVYYCARDG YYRDTDVLDY WGQGTLVTVS
SGGGGSGGGG SGGGGSDIQM TQSPSSLSAS VGDRVTITCQ ASQDISNYLN WYQQKPGKAP
KLLIYYTSRL HTGVPSRFSG SGSGTDFTFT ISSLEPEDIA TYYCQQGNTL PWTFGCGTKV
EIKSGGGGSE VQLVESGGGL VQPGGSLKLS CAASGFTFNK YAMNWVRQAP GKGLEWVARI
RSKYNNYATY YADSVKDRFT ISRDDSKNTA YLQMNNLKTE DTAVYYCVRH GNFGNSYISY
WAYWGQGTLV TVSSGGGGSG GGGSGGGGSQ TVVTQEPSLT
VSPGGTVTLT CGSSTGAVTS GNYPNWVQQK PGQAPRGLIG GTKFLAPGTP ARFSGSLLGG
KAALTLSGVQ PEDEAEYYCV LWYSNRWVFG GGTKLTVLGG GGDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPCEEQYGS
TYRCVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGKG GGGSGGGGSG GGGSGGGGSG GGGSGGGGSD
KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG
VEVHNAKTKP CEEQYGSTYR CVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG
QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD
GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Disulfide bridge: 22-96, 44-236, 159-224, 271-347, 411-479, 508-765, 511-768, 543-603, 574-584, 649-707, 800-860, 831-841, 906-964)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Treatment of multiple myeloma
Target
TNFRSF17 (BCMA, CD269) [HSA:608] [KO:K05153]
CD3E [HSA:916] [KO:K06451]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04640  Hematopoietic cell lineage
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF17 (BCMA, CD269)
     D11992  Pavurutamab (USAN)
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3E
     D11992  Pavurutamab (USAN)
Other DBs
CAS: 2250292-39-6
LinkDB

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