KEGG   DRUG: Feladilimab
Entry
D11996                      Drug                                   
Name
Feladilimab (USAN/INN);
Feladilimab (genetical recombination) (JAN)
Formula
C6450H9888N1696O2036S46
Exact mass
145150.9489
Mol weight
145240.6573
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYTFT DYAMHWVRQA PGQGLEWMGL ISIYSDHTNY
NQKFQGRVTI TADKSTSTAY MELSSLRSED TAVYYCGRNN YGNYGWYFDV WGQGTTVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC PAPEFEGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY TLPPSQEEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR LTVDKSRWQE
GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCSASSSVS YMHWYQQKPG QAPRLLIYDT SKLASGIPAR
FSGSGSGTDY TLTISSLEPE DFAVYYCFQG SGYPYTFGQG TKLEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: H22-H96, H135-L213, H148-H204, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'26, H'135-L'213, H'148-H'204, H'262-H'322, H'368-H'426, L23-L87, L133-L193, L'23-L'87, L'133-L'193)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Treatment of advanced solid tumors
Target
ICOS (CD278) [HSA:29851] [KO:K06713]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    ICOS (CD278)
     D11996  Feladilimab (USAN/INN)
Other DBs
CAS: 2252518-85-5
LinkDB

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