KEGG   DRUG: Drospirenone and estetrol
Entry
D12047            Mixture   Drug                                   
Name
Drospirenone and estetrol;
Nextstellis (TN);
Drovelis (TN);
Lydisilka (TN);
Alyssa (TN)
Product
Component
Drospirenone [DR:D03917], Estetrol [DR:D11514]
Class
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03190  UGT2B7 substrate
Remark
Therapeutic category: 2482
ATC code: G03AA18
Product: D12047<JP/US>
Efficacy
Contraceptive
Comment
Estetrol is metabolized by UGT2B7.
Metabolism
Enzyme: UGT2B7 [HSA:7364]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AA Progestogens and estrogens, fixed combinations
     G03AA18 Drospirenone and estetrol
      D12047  Drospirenone and estetrol <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Contraceptives Combinations
   Drospirenone/ Estetrol
    D12047  Drospirenone and estetrol
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   248  Mixed hormone preparations
    2482  Estrogens and progestins
     D12047  Drospirenone and estetrol
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03190  UGT2B7 substrate
    D12047  Drospirenone and estetrol
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12047
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12047
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12047
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12047
Other DBs
PubChem: 497620460
LinkDB

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