KEGG   DRUG: Poziotinib
Entry
D12229                      Drug                                   
Name
Poziotinib (USAN/INN)
Formula
C23H21Cl2FN4O3
Exact mass
490.0975
Mol weight
491.34
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03158  HER2 inhibitor
Remark
Chemical structure group: DG03196
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
EGFR [HSA:1956] [KO:K04361]
ERBB2 (HER2, CD340) [HSA:2064] [KO:K05083]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03158  HER2 inhibitor
     DG03196  Poziotinib
      D12229  Poziotinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR
     D12229  Poziotinib (USAN/INN)
    ERBB2 (HER2, CD340)
     D12229  Poziotinib (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03158  HER2 inhibitor
     DG03196  Poziotinib
Other DBs
CAS: 1092364-38-9
PubChem: 497620642
ChEBI: 195559
LinkDB
KCF data

ATOM        33
            1   N1b N    13.4400  -17.3600
            2   C8y C    13.4400  -15.9600
            3   C8y C    14.6300  -15.2600
            4   C8y C    14.6300  -13.8600
            5   N5x N    13.4400  -13.1600
            6   C8x C    12.2500  -13.8600
            7   N5x N    12.2500  -15.2600
            8   C8x C    15.8900  -15.9600
            9   C8y C    17.0800  -15.2600
            10  C8y C    17.0800  -13.8600
            11  C8x C    15.8900  -13.1600
            12  O2a O    18.2700  -15.9600
            13  C1y C    19.4600  -15.2600
            14  C1x C    20.6500  -15.9600
            15  C1x C    21.9100  -15.2600
            16  N1y N    21.9100  -13.8600
            17  C1x C    20.7200  -13.1600
            18  C1x C    19.4600  -13.8600
            19  C5a C    23.1000  -13.1600
            20  C2b C    24.2900  -13.8600
            21  C2a C    25.4800  -13.1600
            22  O5a O    23.1000  -11.7600
            23  O2a O    18.2700  -13.1600
            24  C1a C    18.2700  -11.7600
            25  C8y C    14.6553  -18.0551
            26  C8y C    14.6611  -19.4597
            27  C8y C    15.8764  -20.1547
            28  C8y C    17.0859  -19.4497
            29  C8x C    17.0801  -18.0451
            30  C8x C    15.8648  -17.3501
            31  X   F    13.4284  -20.1785
            32  X   Cl   15.8821  -21.5600
            33  X   Cl   18.3012  -20.1446
BOND        36
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     6   7 2
            7     2   7 1
            8     3   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    4  11 1
            13    9  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21   16  19 1
            22   19  20 1
            23   20  21 2
            24   19  22 2
            25   10  23 1
            26   23  24 1
            27    1  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   25  30 1
            34   26  31 1
            35   27  32 1
            36   28  33 1

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