| Entry |
|
|---|
| Name |
Poziotinib hydrochloride (USAN) |
|---|
| Formula |
C23H21Cl2FN4O3. HCl
|
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| Exact mass |
526.0742
|
|---|
| Mol weight |
527.80
|
|---|
| Structure |
|
|---|
| Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
|---|
| Target |
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|---|
| Pathway |
|
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| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG03196 Poziotinib
D12230 Poziotinib hydrochloride
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
EGFR family
EGFR
D12230 Poziotinib hydrochloride (USAN)
ERBB2 (HER2, CD340)
D12230 Poziotinib hydrochloride (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03158 HER2 inhibitor
DG03196 Poziotinib
|
|---|
| Other DBs |
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|---|
| LinkDB |
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|---|
| KCF data |
ATOM 34
1 N1b N 13.2363 -16.8780
2 C8y C 13.2363 -15.4774
3 C8y C 14.4269 -14.7770
4 C8y C 14.4269 -13.3764
5 N5x N 13.2363 -12.6760
6 C8x C 12.0457 -13.3764
7 N5x N 12.0457 -14.7770
8 C8x C 15.6874 -15.4774
9 C8y C 16.8780 -14.7770
10 C8y C 16.8780 -13.3764
11 C8x C 15.6874 -12.6760
12 O2a O 18.0686 -15.4774
13 C1y C 19.2591 -14.7770
14 C1x C 20.4497 -15.4774
15 C1x C 21.7103 -14.7770
16 N1y N 21.7103 -13.3764
17 C1x C 20.5197 -12.6760
18 C1x C 19.2591 -13.3764
19 C5a C 22.9009 -12.6760
20 C2b C 24.0914 -13.3764
21 C2a C 25.2820 -12.6760
22 O5a O 22.9009 -11.2754
23 O2a O 18.0686 -12.6760
24 C1a C 18.0686 -11.2754
25 C8y C 14.4969 -17.5783
26 C8y C 14.4969 -18.9790
27 C8y C 15.6874 -19.6793
28 C8y C 16.8780 -18.9790
29 C8x C 16.8780 -17.5783
30 C8x C 15.6874 -16.8780
31 X F 13.2363 -19.7494
32 X Cl 15.6874 -21.0800
33 X Cl 18.1386 -19.6793
34 X Cl 25.1300 -19.5300
BOND 36
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 6 7 2
7 2 7 1
8 3 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 4 11 1
13 9 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 13 18 1
21 16 19 1
22 19 20 1
23 20 21 2
24 19 22 2
25 10 23 1
26 23 24 1
27 1 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 28 29 1
32 29 30 2
33 25 30 1
34 26 31 1
35 27 32 1
36 28 33 1
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