KEGG   DRUG: Motixafortide acetate
Entry
D12282                      Drug                                   
Name
Motixafortide acetate (USAN);
Aphexda (TN)
Product
Formula
C97H144FN33O19S2. (C2H4O2)x
Remark
ATC code: L03AX23
Chemical structure group: DG03214
Product (DG03214): D12282<US>
Efficacy
Antineoplastic
  Disease
Multiple myeloma [DS:H00010]
Comment
Indicated in combination with filgrastim [DR:D03235] to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma.
Target
CXCR4 (CD184) [HSA:7852] [KO:K04189]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa05200  Pathways in cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AX Other immunostimulants
     L03AX23 Motixafortide
      D12282  Motixafortide acetate (USAN) <US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Blood Products and Modifiers, Other
   Motixafortide
    D12282  Motixafortide acetate (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CXCR4 (CD184)
     D12282  Motixafortide acetate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12282
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12282
Other DBs
CAS: 2639893-42-6
PubChem: 497620695
ChEBI: 229224
LinkDB

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