KEGG   ORTHOLOGY: K04189
Entry
K04189                      KO                                     
Symbol
CXCR4, CD184
Name
C-X-C chemokine receptor type 4
Pathway
map03250  Viral life cycle - HIV-1
map03260  Virion - Human immunodeficiency virus
map04020  Calcium signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04062  Chemokine signaling pathway
map04144  Endocytosis
map04360  Axon guidance
map04670  Leukocyte transendothelial migration
map04672  Intestinal immune network for IgA production
map04810  Regulation of actin cytoskeleton
map05163  Human cytomegalovirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
Disease
H00097  WHIM syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   03260 Virion - Human immunodeficiency virus
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04061 Viral protein interaction with cytokine and cytokine receptor
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04672 Intestinal immune network for IgA production
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04062 Chemokine signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09158 Development and regeneration
   04360 Axon guidance
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   05163 Human cytomegalovirus infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04050 Cytokine receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04090 CD molecules
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Chemokine
   CXC Chemokine
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
Cytokine receptors [BR:ko04050]
 Chemokine receptors
  CXC Chemokine
   K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
CD molecules [BR:ko04090]
 Proteins
  K04189  CD184, CXCR4; chemokine (C-X-C motif) receptor 4
Other DBs
GO: 0016494
TC: 9.A.14.13.17
Genes
HSA: 7852(CXCR4)
PTR: 450130(CXCR4)
PPS: 100968161(CXCR4)
GGO: 101137662(CXCR4)
PON: 100451032(CXCR4)
NLE: 100604120(CXCR4)
MCC: 707329(CXCR4)
MCF: 102142487(CXCR4)
MTHB: 126932241
CSAB: 103216995(CXCR4)
CATY: 105590357(CXCR4)
PANU: 100126711(CXCR4)
TGE: 112636377(CXCR4)
RRO: 104668781(CXCR4)
RBB: 108539652(CXCR4)
TFN: 117095065(CXCR4)
PTEH: 111527474(CXCR4)
CJC: 100406954(CXCR4)
SBQ: 101042221(CXCR4)
CSYR: 103273984(CXCR4)
MMUR: 105857645(CXCR4)
LCAT: 123643287(CXCR4)
OGA: 100945275(CXCR4)
MMU: 12767(Cxcr4)
MCAL: 110299256(Cxcr4)
MPAH: 110321797(Cxcr4)
RNO: 60628(Cxcr4)
MCOC: 116098629(Cxcr4)
MUN: 110555409(Cxcr4)
CGE: 100767733(Cxcr4)
MAUA: 101843789(Cxcr4)
PLEU: 114696964(Cxcr4)
MORG: 121446134(Cxcr4)
MFOT: 126505129
AAMP: 119827638(Cxcr4)
NGI: 103734615(Cxcr4)
HGL: 101699254(Cxcr4)
CPOC: 100731341(Cxcr4)
CCAN: 109695609(Cxcr4)
DORD: 105996637(Cxcr4)
DSP: 122110827(Cxcr4)
NCAR: 124980050
OCU: 100346189(CXCR4)
OPI: 101532462(CXCR4)
TUP: 102472005(CXCR4)
CFA: 119863891
CLUD: 112648781(CXCR4)
VVP: 112932607(CXCR4)
VLG: 121481793(CXCR4)
AML: 100468194(CXCR4)
UMR: 103667676(CXCR4)
UAH: 113263416(CXCR4)
UAR: 123782571(CXCR4)
ELK: 111145588
LLV: 125096040
MPUF: 101675302(CXCR4)
ORO: 101372091(CXCR4)
EJU: 114207323(CXCR4)
ZCA: 113919282(CXCR4)
MLX: 118012497(CXCR4)
NSU: 110585658(CXCR4)
FCA: 493676(CXCR4)
PYU: 121030500(CXCR4)
PBG: 122481291(CXCR4)
LRUF: 124515642
PTG: 102955333(CXCR4)
PPAD: 109270372(CXCR4)
AJU: 106969444(CXCR4)
HHV: 120230386(CXCR4)
BTA: 281736(CXCR4)
BOM: 102280853(CXCR4)
BIU: 109568167(CXCR4)
BBUB: 102394323(CXCR4)
CHX: 102169916(CXCR4)
OAS: 443532(CXCR4)
ODA: 120854493(CXCR4)
CCAD: 122453854(CXCR4)
SSC: 396659(CXCR4)
CFR: 102513077(CXCR4)
CBAI: 105083390(CXCR4)
CDK: 105092280(CXCR4)
VPC: 102542727(CXCR4)
BACU: 103004476(CXCR4)
LVE: 103073013(CXCR4)
OOR: 101270504(CXCR4)
DLE: 111172717(CXCR4)
PCAD: 102989559(CXCR4)
PSIU: 116757109(CXCR4)
ECB: 100050974(CXCR4)
EPZ: 103548930(CXCR4)
EAI: 106836546(CXCR4)
MYB: 102263583(CXCR4)
MYD: 102753258(CXCR4)
MMYO: 118661864(CXCR4)
MLF: 102427675(CXCR4)
MNA: 107531145(CXCR4)
PKL: 118709679(CXCR4)
HAI: 109392711(CXCR4)
DRO: 112313099(CXCR4)
SHON: 118974799(CXCR4)
AJM: 119049942(CXCR4)
PDIC: 114494698(CXCR4)
PHAS: 123810370(CXCR4)
MMF: 118625406(CXCR4)
RFQ: 117026300(CXCR4)
PALE: 102888277(CXCR4)
PGIG: 120611948(CXCR4)
PVP: 105288337(CXCR4)
RAY: 107511206(CXCR4)
MJV: 108401250(CXCR4)
TOD: 119255793(CXCR4)
SARA: 101547089(CXCR4)
LAV: 100660744(CXCR4)
TMU: 101349103
DNM: 101440322(CXCR4)
MDO: 100016627(CXCR4)
GAS: 123239333(CXCR4)
SHR: 100934336(CXCR4)
PCW: 110223779(CXCR4)
OAA: 100079713(CXCR4)
GGA: 395324(CXCR4)
PCOC: 116227436(CXCR4)
MGP: 100541154(CXCR4)
CJO: 107316951(CXCR4)
NMEL: 110400376(CXCR4)
APLA: 101800439(CXCR4)
ACYG: 106039298(CXCR4)
AFUL: 116490781(CXCR4)
TGU: 100229955(CXCR4)
LSR: 110480593(CXCR4)
SCAN: 103814274(CXCR4)
PMOA: 120508805(CXCR4)
OTC: 121336778(CXCR4)
PRUF: 121356518(CXCR4)
GFR: 102040756(CXCR4)
FAB: 101817227(CXCR4)
PHI: 102099500(CXCR4)
PMAJ: 107207830(CXCR4)
CCAE: 111931764(CXCR4)
CCW: 104694218(CXCR4)
CBRC: 103619653(CXCR4)
ETL: 114057696(CXCR4)
ZAB: 102060444(CXCR4)
ACHL: 103811557(CXCR4)
FPG: 101917697(CXCR4)
FCH: 102055350(CXCR4)
CLV: 102086794(CXCR4)
EGZ: 104129523(CXCR4)
NNI: 104009787(CXCR4)
PLET: 104627741(CXCR4)
PCRI: 104026475(CXCR4)
PCAO: 104041542(CXCR4)
ACUN: 113482188(CXCR4)
TALA: 104362077(CXCR4)
PADL: 103912661(CXCR4)
AFOR: 103899500(CXCR4)
ACHC: 115342992(CXCR4)
HALD: 104317924(CXCR4)
CCRI: 104156851(CXCR4)
CSTI: 104556287(CXCR4)
EHS: 104510132(CXCR4)
CMAC: 104487804(CXCR4)
MUI: 104537674(CXCR4)
FGA: 104072040(CXCR4)
GSTE: 104253161(CXCR4)
LDI: 104353098(CXCR4)
MNB: 103772864(CXCR4)
OHA: 104333267(CXCR4)
NNT: 104405428(CXCR4)
DPUB: 104296942(CXCR4)
PGUU: 104472494(CXCR4)
ACAR: 104521945(CXCR4)
AVIT: 104277144(CXCR4)
CVF: 104287977(CXCR4)
CUCA: 104065224(CXCR4)
AAM: 106498424(CXCR4)
AROW: 112977106(CXCR4)
NPD: 112948630(CXCR4)
TGT: 104573182(CXCR4)
SCAM: 104145724(CXCR4)
ASN: 102370606(CXCR4)
AMJ: 102568735(CXCR4)
CPOO: 109323157(CXCR4)
GGN: 109301354(CXCR4)
PSS: 102450615(CXCR4)
CMY: 102947229(CXCR4)
CPIC: 101934476(CXCR4)
TST: 117885175(CXCR4)
CABI: 116825876(CXCR4)
MRV: 120374244(CXCR4)
ACS: 100567304(cxcr4)
PVT: 110071869(CXCR4)
SUND: 121931002(CXCR4)
PBI: 103066628(CXCR4)
PMUR: 107284398(CXCR4) 107301724
CTIG: 120307499(CXCR4)
TSR: 106539054(CXCR4)
PGUT: 117669696(CXCR4)
VKO: 123027385(CXCR4)
PMUA: 114604641(CXCR4)
ZVI: 118092519(CXCR4)
GJA: 107115414(CXCR4)
STOW: 125425697(CXCR4)
XLA: 100192360(cxcr4.L) 380373(cxcr4.S)
XTR: 100038176(cxcr4)
NPR: 108791340(CXCR4)
RTEM: 120944142(CXCR4)
BBUF: 121008243(CXCR4)
BGAR: 122944750(CXCR4)
DRE: 114447(cxcr4b) 140747(cxcr4a)
PPRM: 120467152(cxcr4b) 120491643(cxcr4a)
MAMB: 125270039(cxcr4b) 125274330(cxcr4a)
IPU: 100335031(cxcr4b) 108272900(cxcr4a)
PHYP: 113526054(cxcr4) 113538220
SMEO: 124383392(cxcr4b) 124383918(cxcr4a)
TFD: 113653167(cxcr4b) 113663578(cxcr4a)
AMEX: 103038682 103039830(cxcr4)
TRU: 101066475(cxcr4)
NCC: 104948641 104967493(cxcr4)
CGOB: 115022626 115025932(cxcr4)
SLUC: 116037714(cxcr4b) 116055083
ECRA: 117953001(cxcr4b) 117954807
ESP: 116698207(cxcr4) 116698735
PFLV: 114563987(cxcr4) 114565452
GAT: 120816637 120834068(cxcr4b)
CUD: 121506598(cxcr4b) 121520294(cxcr4a)
ALAT: 119011440 119026431(cxcr4b)
MZE: 101476920(cxcr4) 101476935
ONL: 100693032 100703262(cxcr4)
OML: 112147558 112154780(cxcr4b)
XMA: 102217040(cxcr4) 102230886
XCO: 114146641 114148729(cxcr4)
XHE: 116721468 116723587(cxcr4)
PRET: 103460829(cxcr4) 103478845
PMEI: 106930916(cxcr4) 106932351
CVG: 107086826 107101500(cxcr4)
NFU: 107384286 107390218(cxcr4)
KMR: 108238272 108238501(cxcr4b)
ALIM: 106522573 106525767(cxcr4)
CSEM: 103392313(cxcr4) 103396234
POV: 109631036(cxcr4) 109647982
SSEN: 122761245(cxcr4a) 122784942
SDU: 111218724(cxcr4) 111228808
HCQ: 109512797 109523409(cxcr4)
BPEC: 110156151(cxcr4) 110173492
MALB: 109972381(cxcr4) 109974077
ELS: 105021320 105022415(cxcr4)
SFM: 108927921(cxcr4) 108928927
AANG: 118213710 118223264(cxcr4a)
LOC: 102684223(cxcr4)
ARUT: 117402385(cxcr4a) 117426295
LCM: 102361208(CXCR4)
CMK: 103180391(cxcr4b)
RTP: 109918216(cxcr4)
 » show all
Reference
PMID:8234909
  Authors
Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C
  Title
A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.
  Journal
Regul Pept 47:247-58 (1993)
DOI:10.1016/0167-0115(93)90392-L
  Sequence
[hsa:7852]
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