KEGG ORTHOLOGY: K04189

ORTHOLOGY: K04189

Entry

K04189                      KO

Symbol

CXCR4, CD184

Name

C-X-C chemokine receptor type 4

Pathway

map03250

Viral life cycle - HIV-1

map03260

Virion - Human immunodeficiency virus

map04020

Calcium signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04062

Chemokine signaling pathway

map04144

Endocytosis

map04360

Axon guidance

map04670

Leukocyte transendothelial migration

map04672

Intestinal immune network for IgA production

map04810

Regulation of actin cytoskeleton

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H00097

WHIM syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   03260 Virion - Human immunodeficiency virus
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04061 Viral protein interaction with cytokine and cytokine receptor
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04672 Intestinal immune network for IgA production
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04062 Chemokine signaling pathway
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09158 Development and regeneration
   04360 Axon guidance
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   05163 Human cytomegalovirus infection
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04050 Cytokine receptors
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
   04090 CD molecules
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Chemokine
   CXC Chemokine
    K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
Cytokine receptors [BR:ko04050]
Chemokine receptors
  CXC Chemokine
   K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
CD molecules [BR:ko04090]
Proteins
  K04189  CD184, CXCR4; chemokine (C-X-C motif) receptor 4

Other DBs

GO:

0016494

TC:	9.A.14.13.17

Genes

HSA:	7852(CXCR4)

PTR:	450130(CXCR4)

PPS:	100968161(CXCR4)

GGO:	101137662(CXCR4)

PON:	100451032(CXCR4)

NLE:	100604120(CXCR4)

HMH:	116462920(CXCR4)

MCC:	707329(CXCR4)

MCF:	102142487(CXCR4)

MTHB:

126932241

MNI:	105492570(CXCR4)

CSAB:

103216995(CXCR4)

CATY:

105590357(CXCR4)

PANU:

100126711(CXCR4)

TGE:	112636377(CXCR4)

MLEU:

105532190(CXCR4)

RRO:	104668781(CXCR4)

RBB:	108539652(CXCR4)

TFN:	117095065(CXCR4)

PTEH:

111527474(CXCR4)

CANG:

105508802(CXCR4)

CJC:	100406954(CXCR4)

SBQ:	101042221(CXCR4)

CIMI:

108293365(CXCR4)

CSYR:

103273984(CXCR4)

MMUR:

105857645(CXCR4)

LCAT:

123643287(CXCR4)

PCOQ:

105815381(CXCR4)

OGA:	100945275(CXCR4)

MMU:	12767(Cxcr4)

MCAL:

110299256(Cxcr4)

MPAH:

110321797(Cxcr4)

RNO:	60628(Cxcr4)

MCOC:

116098629(Cxcr4)

ANU:	117716225(Cxcr4)

MUN:	110555409(Cxcr4)

CGE:	100767733(Cxcr4)

MAUA:

101843789(Cxcr4)

PROB:

127236416(Cxcr4)

PLEU:

114696964(Cxcr4)

MORG:

121446134(Cxcr4)

MFOT:

126505129

AAMP:

119827638(Cxcr4)

NGI:	103734615(Cxcr4)

HGL:	101699254(Cxcr4)

CPOC:

100731341(Cxcr4)

CCAN:

109695609(Cxcr4)

DORD:

105996637(Cxcr4)

DSP:	122110827(Cxcr4)

PLOP:

125350729(Cxcr4)

NCAR:

124980050

MMMA:

107136819(Cxcr4)

OCU:

100346189

OPI:	101532462(CXCR4)

TUP:	102472005(CXCR4)

GVR:	103591817(CXCR4)

CFA:

119863891

CLUD:

112648781(CXCR4)

VVP:	112932607(CXCR4)

VLG:	121481793(CXCR4)

NPO:	129495495 129513052 129514745

AML:	100468194(CXCR4)

UMR:	103667676(CXCR4)

UAH:	113263416(CXCR4)

UAR:	123782571(CXCR4)

ELK:

111145588

LLV:

125096040

MPUF:

101675302(CXCR4)

MNP:	132013919(CXCR4)

MLK:	131826966(CXCR4)

NVS:	122902697(CXCR4)

ORO:	101372091(CXCR4)

EJU:	114207323(CXCR4)

ZCA:	113919282(CXCR4)

MLX:	118012497(CXCR4)

NSU:	110585658(CXCR4)

LWW:	102747594(CXCR4)

FCA:	493676(CXCR4)

PYU:	121030500(CXCR4)

PCOO:

112848859(CXCR4)

PBG:	122481291(CXCR4)

PVIV:

125172354(CXCR4)

LRUF:

124515642

PTG:	102955333(CXCR4)

PPAD:

109270372(CXCR4)

PUC:

125911659

AJU:

106969444

HHV:	120230386(CXCR4)

BTA:	281736(CXCR4)

BOM:	102280853(CXCR4)

BIU:	109568167(CXCR4)

BBUB:

102394323(CXCR4)

BBIS:

104998489(CXCR4)

CHX:	102169916(CXCR4)

OAS:	443532(CXCR4)

BTAX:

128070914(CXCR4)

ODA:	120854493(CXCR4)

CCAD:

122453854(CXCR4)

MBEZ:

129538394(CXCR4)

SSC:	396659(CXCR4)

CFR:	102513077(CXCR4)

CBAI:

105083390(CXCR4)

CDK:	105092280(CXCR4)

VPC:	102542727(CXCR4)

BACU:

103004476(CXCR4)

BMUS:

118898081(CXCR4)

LVE:	103073013(CXCR4)

OOR:	101270504(CXCR4)

DLE:	111172717(CXCR4)

PCAD:

102989559(CXCR4)

PSIU:

116757109(CXCR4)

NASI:

112412428(CXCR4)

ECB:	100050974(CXCR4)

EPZ:	103548930(CXCR4)

EAI:	106836546(CXCR4)

MYB:	102263583(CXCR4)

MYD:	102753258(CXCR4)

MMYO:

118661864(CXCR4)

MLF:	102427675(CXCR4)

PKL:	118709679(CXCR4)

EFUS:

103287770(CXCR4)

MNA:	107531145(CXCR4)

DRO:	112313099(CXCR4)

SHON:

118974799(CXCR4)

AJM:	119049942(CXCR4)

PDIC:

114494698(CXCR4)

PHAS:

123810370(CXCR4)

MMF:	118625406(CXCR4)

PPAM:

129061872(CXCR4)

HAI:	109392711(CXCR4)

RFQ:	117026300(CXCR4)

PALE:

102888277(CXCR4)

PGIG:

120611948(CXCR4)

PVP:	105288337(CXCR4)

RAY:	107511206(CXCR4)

MJV:	108401250(CXCR4)

TOD:	119255793(CXCR4)

SARA:

101547089(CXCR4)

SETR:

126009206(CXCR4)

LAV:	100660744(CXCR4)

TMU:

101349103

ETF:	101658890(CXCR4)

DNM:	101440322(CXCR4)

MDO:	100016627(CXCR4)

GAS:	123239333(CXCR4)

SHR:	100934336(CXCR4)

AFZ:

127554363

PCW:	110223779(CXCR4)

OAA:	100079713(CXCR4)

GGA:	395324(CXCR4)

PCOC:

116227436(CXCR4)

MGP:	100541154(CXCR4)

CJO:	107316951(CXCR4)

TPAI:

128076754(CXCR4)

LMUT:

125696554(CXCR4)

NMEL:

110400376(CXCR4)

APLA:

101800439(CXCR4)

ACYG:

106039298(CXCR4)

CATA:

118252579(CXCR4)

AFUL:

116490781(CXCR4)

TGU:	100229955(CXCR4)

LSR:	110480593(CXCR4)

SCAN:

103814274(CXCR4)

PMOA:

120508805(CXCR4)

OTC:	121336778(CXCR4)

PRUF:

121356518(CXCR4)

GFR:	102040756(CXCR4)

FAB:	101817227(CXCR4)

OMA:	130255356(CXCR4)

PHI:	102099500(CXCR4)

PMAJ:

107207830(CXCR4)

CCAE:

111931764(CXCR4)

CCW:	104694218(CXCR4)

CBRC:

103619653(CXCR4)

ETL:	114057696(CXCR4)

ZAB:	102060444(CXCR4)

ACHL:

103811557(CXCR4)

SVG:	106849899(CXCR4)

MMEA:

130573817(CXCR4)

HRT:	120755013(CXCR4)

FPG:	101917697(CXCR4)

FCH:	102055350(CXCR4)

CLV:	102086794(CXCR4)

EGZ:	104129523(CXCR4)

NNI:	104009787(CXCR4)

PCRI:

104026475(CXCR4)

PLET:

104627741(CXCR4)

EHS:	104510132(CXCR4)

PCAO:

104041542(CXCR4)

ACUN:

113482188(CXCR4)

TALA:

104362077(CXCR4)

PADL:

103912661(CXCR4)

AFOR:

103899500(CXCR4)

ACHC:

115342992(CXCR4)

HALD:

104317924(CXCR4)

HLE:	104836529(CXCR4)

AGEN:

126042565

GCL:

127018498

CCRI:

104156851(CXCR4)

CSTI:

104556287(CXCR4)

CMAC:

104487804(CXCR4)

MUI:	104537674(CXCR4)

BREG:

104633630(CXCR4)

FGA:	104072040(CXCR4)

GSTE:

104253161(CXCR4)

LDI:	104353098(CXCR4)

MNB:	103772864(CXCR4)

OHA:	104333267(CXCR4)

NNT:	104405428(CXCR4)

SHAB:

115608648(CXCR4)

DPUB:

104296942(CXCR4)

PGUU:

104472494(CXCR4)

ACAR:

104521945(CXCR4)

CPEA:

104391156(CXCR4)

AVIT:

104277144(CXCR4)

CVF:	104287977(CXCR4)

RTD:	128912245(CXCR4)

CUCA:

104065224(CXCR4)

TEO:	104371655(CXCR4)

BRHI:

104490883(CXCR4)

AAM:	106498424(CXCR4)

AROW:

112977106(CXCR4)

NPD:	112948630(CXCR4)

TGT:	104573182(CXCR4)

DNE:	112988309 112997455

SCAM:

104145724(CXCR4)

ASN:	102370606(CXCR4)

AMJ:	102568735(CXCR4)

CPOO:

109323157(CXCR4)

GGN:	109301354(CXCR4)

PSS:	102450615(CXCR4)

CMY:	102947229(CXCR4)

CCAY:

125645168(CXCR4)

DCC:	119863218(CXCR4)

CPIC:

101934476(CXCR4)

TST:	117885175(CXCR4)

CABI:

116825876(CXCR4)

MRV:	120374244(CXCR4)

ACS:	100567304(cxcr4)

ASAO:

132775215(CXCR4)

PVT:	110071869(CXCR4)

SUND:

121931002(CXCR4)

PBI:	103066628(CXCR4)

PMUR:

107284398(CXCR4) 107301724

CTIG:

120307499(CXCR4)

TSR:	106539054(CXCR4)

PGUT:

117669696(CXCR4)

APRI:

131203520(CXCR4)

PTEX:

113445468(CXCR4)

NSS:	113410708(CXCR4)

VKO:	123027385(CXCR4)

PMUA:

114604641(CXCR4)

PRAF:

128422097(CXCR4)

ZVI:	118092519(CXCR4)

HCG:	128341052(CXCR4)

GJA:	107115414(CXCR4)

STOW:

125425697(CXCR4)

EMC:	129323432(CXCR4)

XLA:	100192360(cxcr4.L) 380373(cxcr4.S)

XTR:	100038176(cxcr4)

NPR:	108791340(CXCR4)

RTEM:

120944142(CXCR4)

BBUF:

121008243(CXCR4)

BGAR:

122944750(CXCR4)

MUO:	115474597 115474875

GSH:	117361035 117361640

DRE:	114447(cxcr4b) 140747(cxcr4a)

SRX:	107705531 107706106 107748581 107749897

SANH:

107660136 107663919 107676218 107688919

SGH:	107555414 107556439 107568342 107584845

CCAR:

109054513 109055968 109070166 109096562

CAUA:

113050798 113053577 113074675 113093371 113108763

CGIB:

127958994 127965452 128015381 128019672

PTET:

122346469(cxcr4a) 122352092(cxcr4b)

LROH:

127166295(cxcr4a) 127171224(cxcr4b)

OMC:	131542452(cxcr4a) 131546929(cxcr4b)

PPRM:

120467152(cxcr4b) 120491643(cxcr4a)

RKG:	130076615(cxcr4b) 130101382(cxcr4a)

MAMB:

125270039(cxcr4b) 125274330(cxcr4a)

CIDE:

127514750 127518441

MASI:

127445855 127447196 127447881 127449676

TROS:

130555641(cxcr4b) 130557360(cxcr4a)

TDW:	130424649(cxcr4a) 130428068(cxcr4b)

MANU:

129450184(cxcr4a) 129452158(cxcr4b)

IPU:	100335031(cxcr4b) 108272900(cxcr4a)

IFU:	128608439(cxcr4b) 128615710(cxcr4a)

PHYP:

113526054(cxcr4) 113538220

SMEO:

124383392(cxcr4b) 124383918(cxcr4a)

TFD:	113653167(cxcr4b) 113663578(cxcr4a)

TVC:	132845005(cxcr4a) 132850444(cxcr4b)

AMEX:

103038682 103039830(cxcr4)

CMAO:

118807477(cxcr4a) 118812101(cxcr4b)

EEE:	113582600 113585300

CHAR:

105902667(cxcr4b) 105912404(cxcr4a)

TRU:	101066475(cxcr4)

TFS:

130527039

TNG:	GSTEN00015094G001 GSTEN00020759G001

LCO:	104926341 104938220

NCC:	104948641 104967493(cxcr4)

TBEN:

117485871 117488395

CGOB:

115022626 115025932(cxcr4)

PGEO:

117462457 117466620

GACU:

117556636 117560135(cxcr4b)

EMAC:

134865487 134867513(cxcr4b)

ELY:	117249806 117271758

EFO:	125899985 125901888

PLEP:

121948919 121951604 121966178

SLUC:

116037714(cxcr4b) 116055083

ECRA:

117953001(cxcr4b) 117954807

ESP:	116698207(cxcr4) 116698735

PFLV:

114563987(cxcr4) 114565452

GAT:	120816637 120834068(cxcr4b)

PPUG:

119209191 119229368

AFB:	129088873 129104510(cxcr4b)

CLUM:

117746112 117750826(cxcr4b)

PSWI:

130198029 130204735(cxcr4b)

MSAM:

119902454 119903907

SCHU:

122886155(cxcr4b) 122886615

CUD:	121506598(cxcr4b) 121520294(cxcr4a)

ALAT:

119011440 119026431(cxcr4b)

MZE:	101476920(cxcr4) 101476935

ONL:	100693032 100703262(cxcr4)

OAU:	116316555 116321542

OLA:	100049444 101160103

OML:	112147558 112154780(cxcr4b)

CSAI:

133446305 133452129

XMA:	102217040(cxcr4) 102230886

XCO:	114146641 114148729(cxcr4)

XHE:	116721468 116723587(cxcr4)

PRET:

103460829(cxcr4) 103478845

PFOR:

103138353 103138356 103150653(cxcr4)

PLAI:

106937576(cxcr4) 106942431 106962105

PMEI:

106930916(cxcr4) 106932351

GAF:	122839569 122840732

PPRL:

129361541 129362049

CVG:	107086826 107101500(cxcr4)

CTUL:

119777472 119797338

GMU:	124870191 124870944

NFU:	107384286 107390218(cxcr4)

KMR:	108238272 108238501(cxcr4b)

ALIM:

106522573 106525767(cxcr4)

NWH:	119414381 119418827

AOCE:

111571313 111571831

MCEP:

125010470 125018158

CSEM:

103392313(cxcr4) 103396234

POV:	109631036(cxcr4) 109647982

SSEN:

122761245(cxcr4a) 122784942

HHIP:

117755139 117778739

HSP:	118118351 118120574

SMAU:

118282861 118311777

LCF:	108883894 108886893

SDU:	111218724(cxcr4) 111228808

SLAL:

111666497 111668384 111668748(cxcr4)

XGL:	120799117 120801102

HCQ:	109512797 109523409(cxcr4)

SSCV:

125973186

SBIA:

133511434 133512078

PEE:	133410506 133411479

PTAO:

133487079 133489284

BPEC:

110156151(cxcr4) 110173492

MALB:

109972381(cxcr4) 109974077

BSPL:

114845178 114847654(cxcr4b) 114850817

SJO:	128368341 128369373

SASA:

100306754(cxcr4) 106569491 106581841 106600212

STRU:

115156111 115157336 115160672 115169470

OTW:	112225152 112226689 112235425 112247434

OMY:	110501543 110516585 110520024 110530627

OGO:	124009818 124015806 124040850 124042872

ONE:	115101728 115108096 115114691 115138692

OKI:	109865795 109871298 109872134 109880005

OKE:	118367152 118385956(cxcr4b) 118395151 118401664

SALP:

111974007 111974259 111979451 112079928

SNH:	120020048 120055635 120057843 120063847

CCLU:

121534725 121536227 121555914 121581559

ELS:	105021320 105022415(cxcr4)

SFM:	108927921(cxcr4) 108928927

PKI:	111849246 111858385

AANG:

118213710 118223264(cxcr4a)

LOC:	102684223(cxcr4)

PSPA:

121322314 121323684

ARUT:

117402385(cxcr4a) 117426295

PSEX:

120531714

LCM:	102361208(CXCR4)

CMK:	103180391(cxcr4b)

RTP:	109918216(cxcr4b)

CPLA:

122551691(cxcr4a)

HOC:

132817406

LERI:

129699042

PMRN:

103091770 116940865 116943820

LRJ:	133344632 133346057 133357668

» show all

Reference

PMID:8234909

Authors

Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C

Title

A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells.

Journal

Regul Pept 47:247-58 (1993)
DOI:10.1016/0167-0115(93)90392-L

Sequence

[hsa:7852]

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