KEGG   DRUG: Datopotamab deruxtecan
Entry
D12359                      Drug                                   
Name
Datopotamab deruxtecan (USAN/INN);
Datopotamab deruxtecan (genetical recombination) (JAN);
Datopotamab deruxtecan-dlnk;
Datroway (TN)
Product
Formula
C6464H9984N1708O2016S44. (C52H57FN9O13)n
Remark
Therapeutic category: 4291
ATC code: L01FX35
Product: D12359<JP/US>
Efficacy
Antineoplastic, Anti-TROP2 antibody, Topoisomerase I inhibitor
  Disease
Breast cancer (HR positive, HER2 negative) [DS:H00031]
  Type
Antibody-drug conjugate
Target
TACSTD2 (TROP2) [HSA:4070] [KO:K17288]
TOP1 [HSA:7150] [KO:K03163]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX35 Datopotamab deruxtecan
      D12359  Datopotamab deruxtecan (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D12359  Datopotamab deruxtecan (USAN/INN); Datopotamab deruxtecan (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Other
    TACSTD2 (TROP2)
     D12359  Datopotamab deruxtecan (USAN/INN) <JP/US>
 Enzymes
  Isomerases (EC5)
   DNA topoisomerase
    TOP1
     D12359  Datopotamab deruxtecan (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12359
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12359
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12359
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12359
Other DBs
CAS: 2238831-60-0
PubChem: 497620772
LinkDB

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