Homo sapiens (human): 7150
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Entry
7150 CDS
T01001
Symbol
TOP1, TOPI
Name
(RefSeq) DNA topoisomerase I
KO
K03163
DNA topoisomerase I [EC:
5.6.2.1
]
Organism
hsa
Homo sapiens (human)
Drug target
Aclarubicin (
DG00699
):
D01911
<JP>
D02756
Belotecan:
D03225
Cositecan:
D09327
Datopotamab deruxtecan:
D12359
Edotecarin:
D03954
Elsamitrucin:
D03977
Etirinotecan pegol (
DG01267
):
D10367
D10422
D10427
Exatecan mesylate:
D01432
Firtecan pegol:
D10464
Ifinatamab deruxtecan:
D12753
Irinotecan (
DG00726
):
D01061
<JP/US>
D08086
D10642
Lurtotecan dihydrochloride:
D04822
Patritumab deruxtecan:
D12184
Pegamotecan:
D05385
Puxitatug samrotecan:
D12927
Rubitecan:
D04031
Sacituzumab govitecan:
D10985
<JP/US>
Samrotecan:
D12919
Tenifatecan:
D09679
Topotecan (
DG00725
):
D02168
<JP/US>
D08618
Trastuzumab deruxtecan:
D11529
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
7150 (TOP1)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.1 DNA topoisomerase
7150 (TOP1)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Topoisomerases
7150 (TOP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Topoisom_I
Topoisom_I_N
Topo_C_assoc
Motif
Other DBs
NCBI-GeneID:
7150
NCBI-ProteinID:
NP_003277
OMIM:
126420
HGNC:
11986
Ensembl:
ENSG00000198900
Pharos:
P11387
(Tclin)
UniProt:
P11387
Q9BVT2
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:41028822..41124487
Genome browser
AA seq
765 aa
AA seq
DB search
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
NT seq
2298 nt
NT seq
+upstream
nt +downstream
nt
atgagtggggaccacctccacaacgattcccagatcgaagcggatttccgattgaatgat
tctcataaacacaaagataaacacaaagatcgagaacaccggcacaaagaacacaagaag
gagaaggaccgggaaaagtccaagcatagcaacagtgaacataaagattctgaaaagaaa
cacaaagagaaggagaagaccaaacacaaagatggaagctcagaaaagcataaagacaaa
cataaagacagagacaaggaaaaacgaaaagaggaaaaggttcgagcctctggggatgca
aaaataaagaaggagaaggaaaatggcttctctagtccaccacaaattaaagatgaacct
gaagatgatggctattttgttcctcctaaagaggatataaagccattaaagagacctcga
gatgaggatgatgctgattataaacctaagaaaattaaaacagaagataccaagaaggag
aagaaaagaaaactagaagaagaagaggatggtaaattgaaaaaacccaagaataaagat
aaagataaaaaagttcctgagccagataacaagaaaaagaagccgaagaaagaagaggaa
cagaagtggaaatggtgggaagaagagcgctatcctgaaggcatcaagtggaaattccta
gaacataaaggtccagtatttgccccaccatatgagcctcttccagagaatgtcaagttt
tattatgatggtaaagtcatgaagctgagccccaaagcagaggaagtagctacgttcttt
gcaaaaatgctcgaccatgaatatactaccaaggaaatatttaggaaaaatttctttaaa
gactggagaaaggaaatgactaatgaagagaagaatattatcaccaacctaagcaaatgt
gattttacccagatgagccagtatttcaaagcccagacggaagctcggaaacagatgagc
aaggaagagaaactgaaaatcaaagaggagaatgaaaaattactgaaagaatatggattc
tgtattatggataaccacaaagagaggattgctaacttcaagatagagcctcctggactt
ttccgtggccgcggcaaccaccccaagatgggcatgctgaagagacgaatcatgcccgag
gatataatcatcaactgtagcaaagatgccaaggttccttctcctcctccaggacataag
tggaaagaagtccggcatgataacaaggttacttggctggtttcctggacagagaacatc
caaggttccattaaatacatcatgcttaaccctagttcacgaatcaagggtgagaaggac
tggcagaaatacgagactgctcggcggctgaaaaaatgtgtggacaagatccggaaccag
tatcgagaagactggaagtccaaagagatgaaagtccggcagagagctgtagccctgtac
ttcatcgacaagcttgctctgagagcaggcaatgaaaaggaggaaggagaaacagcggac
actgtgggctgctgctcacttcgtgtggagcacatcaatctacacccagagttggatggt
caggaatatgtggtagagtttgacttcctcgggaaggactccatcagatactataacaag
gtccctgttgagaaacgagtttttaagaacctacaactatttatggagaacaagcagccc
gaggatgatctttttgatagactcaatactggtattctgaataagcatcttcaggatctc
atggagggcttgacagccaaggtattccgtacatacaatgcctccatcacgctacagcag
cagctaaaagaactgacagccccggatgagaacatcccagcgaagatcctttcttataac
cgtgccaatcgagctgttgcaattctttgtaaccatcagagggcaccaccaaaaactttt
gagaagtctatgatgaacttgcaaactaagattgatgccaagaaggaacagctagcagat
gcccggagagacctgaaaagtgctaaggctgatgccaaggtcatgaaggatgcaaagacg
aagaaggtagtagagtcaaagaagaaggctgttcagagactggaggaacagttgatgaag
ctggaagttcaagccacagaccgagaggaaaataaacagattgccctgggaacctccaaa
ctcaattatctggaccctaggatcacagtggcttggtgcaagaagtggggtgtcccaatt
gagaagatttacaacaaaacccagcgggagaagtttgcctgggccattgacatggctgat
gaagactatgagttttag
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integrated database retrieval system