KEGG   DRUG: Lusvertikimab
Entry
D12479                      Drug                                   
Name
Lusvertikimab (USAN/INN)
Formula
C6484H9968N1708O2024S44
Exact mass
145551.7286
Mol weight
145641.69
Sequence
(Heavy chain)
QVQLVESGGG LVKPGGSLRL SCAVSGFTLS DYYMAWIRQA PGKGLEWVST ISASGLRTYY
PDSVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARPL SAHYGFNYFD YWGQGTLVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPP CPAPEFLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ
EGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRTSEDIY QGLAWYQQKP GKAPKLLLYS ANTLHIGVPS
RFSGSGSGTD YTLTISSLQP EDFATYYCQQ YYDYPLAFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H136-L214, H149-H205, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'96, H'136-L'214, H'149-H'205, H'263-H'323, H'369-H'427, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Efficacy
Autoimmune disease treatment, Anti-IL7 receptor antibody
  Type
Monoclonal antibody
Comment
Treatment of autoimmune disease, including ulcerative colitis and primary Sjogren syndrome
Target
IL7R (CD127) [HSA:3575] [KO:K05072]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D12479  Lusvertikimab
Target-based classification of drugs [BR:br08310]
 Signaling molecules and receptors
  Cytokine receptors
   Interleukin receptors
    IL7R (CD127)
     D12479  Lusvertikimab (USAN/INN)
Other DBs
CAS: 2375835-91-7
PubChem: 497620892
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system