KEGG ORTHOLOGY: K05072

ORTHOLOGY: K05072

Entry

K05072                      KO

Symbol

IL7R, CD127

Name

interleukin 7 receptor

Pathway

map04060

Cytokine-cytokine receptor interaction

map04068

FoxO signaling pathway

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04640

Hematopoietic cell lineage

map05200

Pathways in cancer

map05340

Primary immunodeficiency

Disease

H00091

T-B+Severe combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05072  IL7R, CD127; interleukin 7 receptor
   04068 FoxO signaling pathway
    K05072  IL7R, CD127; interleukin 7 receptor
   04151 PI3K-Akt signaling pathway
    K05072  IL7R, CD127; interleukin 7 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05072  IL7R, CD127; interleukin 7 receptor
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05072  IL7R, CD127; interleukin 7 receptor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05072  IL7R, CD127; interleukin 7 receptor
  09163 Immune disease
   05340 Primary immunodeficiency
    K05072  IL7R, CD127; interleukin 7 receptor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05072  IL7R, CD127; interleukin 7 receptor
   04090 CD molecules
    K05072  IL7R, CD127; interleukin 7 receptor
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05072  IL7R, CD127; interleukin 7 receptor
CD molecules [BR:ko04090]
Proteins
  K05072  CD127, IL7R; interleukin 7 receptor

Other DBs

GO:

0004917

Genes

HSA:	3575(IL7R)

PTR:	461922(IL7R)

PPS:	100981232(IL7R)

GGO:	101140372(IL7R)

PON:	100461835(IL7R)

NLE:	100583768(IL7R)

HMH:	116456636(IL7R)

MCC:	699869(IL7R)

MCF:	102143679(IL7R)

MTHB:

126956291

MNI:	105473067(IL7R)

CSAB:

103215123(IL7R)

CATY:

105583419(IL7R)

PANU:

100997339(IL7R)

TGE:	112626005(IL7R)

MLEU:

105555430(IL7R)

RRO:	104662030(IL7R)

RBB:	108533533(IL7R)

TFN:	117065018(IL7R)

PTEH:

111545525(IL7R)

CANG:

105513481(IL7R)

CJC:	100397720(IL7R)

SBQ:	101044161(IL7R)

CIMI:

108317638(IL7R)

CSYR:

103255407(IL7R)

MMUR:

105855452(IL7R)

LCAT:

123647965(IL7R)

PCOQ:

105814655(IL7R)

OGA:	100958917(IL7R)

MMU:	16197(Il7r)

MCAL:

110310926(Il7r)

MPAH:

110329173(Il7r)

RNO:	294797(Il7r)

MCOC:

116083490(Il7r)

ANU:	117724027(Il7r)

CGE:	100757700(Il7r)

MAUA:

101826635(Il7r)

PROB:

127220635(Il7r)

PLEU:

114710803(Il7r)

MORG:

121433021(Il7r)

MFOT:

126499758

AAMP:

119810072(Il7r)

NGI:	103741311(Il7r)

HGL:	101710077(Il7r)

CPOC:

100714027(Il7r)

CCAN:

109698833(Il7r)

DORD:

105987365(Il7r)

DSP:	122116962(Il7r)

PLOP:

125367735(Il7r)

NCAR:

124987542

MMMA:

107151121(Il7r)

OCU:

100343726

OPI:	101519852(IL7R)

TUP:	102499643(IL7R)

GVR:	103592180(IL7R)

CFA:	612582(IL7R)

CLUD:

112652729(IL7R)

VVP:	112933551(IL7R)

VLG:	121486166(IL7R)

NPO:	129509638(IL7R)

AML:	100477617(IL7R)

UMR:	103664716(IL7R)

UAH:	113260884(IL7R)

UAR:	123785472(IL7R)

ELK:

111141253

LLV:

125100556

MPUF:

101686489(IL7R)

MNP:	132028244(IL7R)

MLK:	131831653(IL7R)

NVS:	122895420(IL7R)

ORO:	101385299(IL7R)

EJU:	114204719(IL7R)

ZCA:	113929577(IL7R)

MLX:	118006362 118006490

NSU:	110586033(IL7R)

LWW:	102746381(IL7R)

FCA:	101100697(IL7R)

PYU:	121043454(IL7R)

PCOO:

112861072(IL7R)

PBG:	122494662(IL7R)

PVIV:

125172581(IL7R)

LRUF:

124522249

PTG:	102953956(IL7R)

PPAD:

109267711(IL7R)

PUC:

125934650

AJU:

106979009

HHV:	120242483(IL7R)

BTA:	521554(IL7R)

BOM:	102284629(IL7R)

BIU:	109575020(IL7R)

BBUB:

102400952(IL7R)

BBIS:

104998559(IL7R)

CHX:	102175248(IL7R)

OAS:	101111126(IL7R)

BTAX:

128066211(IL7R)

ODA:	120879335(IL7R)

CCAD:

122454504(IL7R)

MBEZ:

129553320(IL7R)

SSC:	100271930(IL7R)

CFR:	102515501(IL7R)

CBAI:

105069416(IL7R)

CDK:	105087002(IL7R)

VPC:	102540191(IL7R)

BACU:

103010049(IL7R)

BMUS:

118892956(IL7R)

LVE:	103089375(IL7R)

OOR:	101275057(IL7R)

DLE:	111187554(IL7R)

PCAD:

102992873(IL7R)

PSIU:

116751594(IL7R)

NASI:

112405988(IL7R)

ECB:	100034169(IL7R) 111769795 111769802

EPZ:	103545416(IL7R)

EAI:	106824753(IL7R)

MYB:	102264253(IL7R)

MYD:	102772772(IL7R)

MMYO:

118656297(IL7R)

MLF:	102426075(IL7R)

PKL:	118703714(IL7R)

EFUS:

103298082(IL7R)

MNA:	107546370(IL7R)

DRO:	112321141(IL7R)

SHON:

118998771(IL7R)

AJM:	119036993(IL7R)

PDIC:

114506652(IL7R)

PHAS:

123824890(IL7R)

MMF:	118641726(IL7R)

PPAM:

129078988(IL7R)

HAI:	109376825(IL7R)

RFQ:	117025154(IL7R)

PALE:

102889092(IL7R)

PGIG:

120586196(IL7R)

PVP:	105305877(IL7R)

RAY:	107509706(IL7R)

MJV:	108406858(IL7R)

TOD:	119261071(IL7R)

SARA:

101554650(IL7R)

SETR:

126000061(IL7R)

LAV:	100671266(IL7R)

TMU:

101351100

ETF:	101647050(IL7R)

DNM:	101443015(IL7R)

MDO:	100020565(IL7R)

GAS:	123231515(IL7R)

SHR:	100915478(IL7R)

AFZ:

127556557

PCW:	110214720(IL7R)

OAA:	100078445(IL7R)

GGA:	426054(IL7R)

PCOC:

116238618(IL7R)

MGP:	100542453(IL7R)

CJO:	107305872(IL7R)

TPAI:

128074557(IL7R)

LMUT:

125687104(IL7R)

NMEL:

110389974(IL7R)

APLA:

101800042(IL7R)

ACYG:

106036382(IL7R)

CATA:

118256646(IL7R)

AFUL:

116500510(IL7R)

TGU:	100226205(IL7R)

LSR:	110482656(IL7R)

SCAN:

103821063(IL7R)

PMOA:

120502476(IL7R)

OTC:	121343751(IL7R)

PRUF:

121365771(IL7R)

GFR:	102033898(IL7R)

FAB:	101816330(IL7R)

OMA:	130264795(IL7R)

PHI:	102109259(IL7R)

PMAJ:

107216341(IL7R)

CCAE:

111940971(IL7R)

CCW:	104686602(IL7R)

CBRC:

103612924(IL7R)

ETL:	114066153(IL7R)

ACHL:

103804055(IL7R)

SVG:	106852732(IL7R)

MMEA:

130572767(IL7R)

HRT:	120765368(IL7R)

FPG:	101911430(IL7R)

FCH:	102052979(IL7R)

CLV:	102085807(IL7R)

EGZ:	104133924(IL7R)

NNI:	104018643(IL7R)

PCRI:

104032904(IL7R)

PLET:

104616776 104618606

EHS:	104511163(IL7R)

PCAO:

104052382(IL7R)

ACUN:

113489797(IL7R)

TALA:

104360483(IL7R)

PADL:

103921479(IL7R)

AFOR:

103903910(IL7R)

ACHC:

115337355(IL7R)

HALD:

104316486(IL7R)

HLE:	104830620(IL7R)

AGEN:

126036529

GCL:

127027731

CCRI:

104160354(IL7R)

CSTI:

104564036(IL7R)

CMAC:

104481228(IL7R)

MUI:	104541244(IL7R)

BREG:

104633450(IL7R)

FGA:	104084162(IL7R)

GSTE:

104264862(IL7R)

LDI:	104343932(IL7R)

MNB:	103770613(IL7R)

OHA:	104337754(IL7R)

NNT:	104408829(IL7R)

SHAB:

115600908(IL7R)

DPUB:

104303140(IL7R)

PGUU:

104468748(IL7R)

ACAR:

104518477(IL7R)

CPEA:

104398624(IL7R)

AVIT:

104270170(IL7R)

CVF:	104295012(IL7R)

RTD:	128902846(IL7R)

CUCA:

104063845(IL7R)

TEO:	104370273(IL7R)

BRHI:

104498744(IL7R)

AAM:	106499523(IL7R)

AROW:

112976238(IL7R)

NPD:	112945900(IL7R)

TGT:	104570696(IL7R)

DNE:	112982195(IL7R)

SCAM:

104147783(IL7R)

ASN:	102368640(IL7R)

AMJ:	102558184(IL7R)

CPOO:

109307831(IL7R)

GGN:	109297899(IL7R)

PSS:	102449770(IL7R)

CMY:	102932302(IL7R)

CCAY:

125637191(IL7R)

DCC:	119856381(IL7R)

CPIC:

101937386(IL7R)

TST:	117879238(IL7R)

CABI:

116824571(IL7R)

MRV:	120408471(IL7R)

ACS:	103279695(il7r)

ASAO:

132766408(IL7R)

PVT:	110080088(IL7R)

SUND:

121924097(IL7R)

PBI:	103058565(IL7R)

PMUR:

107297967(IL7R)

CTIG:

120310016(IL7R)

TSR:	106551942(IL7R)

PGUT:

117679991(IL7R)

APRI:

131193287(IL7R)

PTEX:

113445160(IL7R)

NSS:	113411319(IL7R)

VKO:	123023985(IL7R)

PMUA:

114606663(IL7R)

PRAF:

128423354(IL7R)

ZVI:	118077302(IL7R)

HCG:	128341591(IL7R)

GJA:	107108287(IL7R)

STOW:

125436803(IL7R)

EMC:	129334503(IL7R)

XTR:	116408012(il7r)

MUO:	115461863(IL7R)

GSH:	117354968(IL7R)

DRE:	100134973(il7r)

SRX:	107718971 107736375

SANH:

107681106 107703538

SGH:	107548123 107551607

CCAR:

109045268 109076405

CAUA:

113038619 113064274

CGIB:

127941297 127985759

PTET:

122326535(il7r)

LROH:

127152958(il7r)

OMC:	131528832(il7r)

PPRM:

120494726(il7r)

RKG:	130096490(il7r) 130106305

MAMB:

125253498(il7r) 125270406

CIDE:

127503412

MASI:

127429027 127430552

TROS:

130570769(il7r)

TDW:	130408314(il7r)

MANU:

129424420(il7r)

IPU:

108279371

IFU:	128622046(il7r)

PHYP:

113541790(il7r)

SMEO:

124397634(il7r)

TFD:	113634945 125139823(il7r)

TVC:	132860466(il7r)

AMEX:

103047579(il7r)

CMAO:

118820374(il7r)

EEE:	113573243(il7r)

CHAR:

116222798(il7r)

TRU:	101078727(il7r)

TFS:	130517192(il7r)

LCO:	104936386(il7r)

PGEO:

117443619(il7r)

ELY:	117270145(il7r)

EFO:	125905939(il7r)

PLEP:

121960269(il7r)

SLUC:

116057125(il7r)

ECRA:

117958974(il7r)

PFLV:

114570789(il7r)

GAT:	120814760(il7r)

PPUG:

119227036

AFB:	129102717(il7r)

CLUM:

117740669(il7r)

PSWI:

130205720

MSAM:

119914859 119914860

SCHU:

122865361(il7r)

ALAT:

119029705(il7r)

MZE:	101477974(il7r)

ONL:	102082329(il7r)

OAU:	116321284(il7r)

OLA:	110013505(il7r)

OML:

112136155

CSAI:

133454796(il7r)

XMA:	102218066(il7r)

XCO:	114150235(il7r)

XHE:	116723975(il7r)

PRET:

103474046

PFOR:

103132534(il7r)

PLAI:

106934702(il7r)

PMEI:

106910402(il7r)

GAF:	122847207(il7r)

PPRL:

129356190

CVG:	107095097(il7r)

CTUL:

119780469(il7r)

GMU:	124872137(il7r)

NFU:	107374989(il7r)

KMR:	108245570(il7r)

ALIM:

106527579

MCEP:

124997149(il7r)

CSEM:

103390387

SSEN:

122758218(il7r) 122776419

HHIP:

117771349(il7r)

HSP:	118125885(il7r)

SMAU:

118284531(il7r)

LCF:	108875542 108892301

SDU:	111238700(il7r)

SLAL:

111652916(il7r)

XGL:	120806671(il7r)

HCQ:	109523342(il7r)

SBIA:

133512511(il7r)

PEE:	133410658(il7r)

PTAO:

133486326(il7r)

BPEC:

110161723(il7r)

MALB:

109973109(il7r)

BSPL:

114867189(il7r)

SJO:	128379951 128379974

SASA:

106563758 106568165

STRU:

115149237(il7r) 115159342

OTW:	112219510(il7r) 112257526

OMY:	101268945 110523781(il7r)

OGO:	124000538 124048749

ONE:	115105871(il7r) 115125716

OKI:	109868011 109892482(il7r)

OKE:	118387739 118391437

SALP:

111961414 111982155(il7r)

SNH:	120026456 120044993

CCLU:

121574395 121582194

ELS:	105014762(il7r)

SFM:	108932322(il7r)

PKI:

111842105

AANG:

118212890(il7r)

LOC:	107076551(il7r)

PSPA:

121304728 121318266

ARUT:

117409050(il7r) 117421234

CPLA:

122558012

HOC:

132826372

LERI:

129694404(il7r)

» show all

Reference

PMID:2317865

Authors

Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE, et al.

Title

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.

Journal

Cell 60:941-51 (1990)
DOI:10.1016/0092-8674(90)90342-C

Sequence

[hsa:3575]

Reference

PMID:8266077

Authors

Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ

Title

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor.

Journal

Science 262:1877-80 (1993)
DOI:10.1126/science.8266077

LinkDB

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