KEGG   DRUG: Orforglipron calcium
Entry
D12529                      Drug                                   
Name
Orforglipron calcium (JAN/USAN);
Foundayo (TN)
Product
FOUNDAYO (Eli Lilly and Company)
Formula
(C48H47F2N10O5)2. Ca
Exact mass
1802.7024
Mol weight
1803.97
Structure
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01493  GLP-1 receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Chemical structure group: DG03257
Product (DG03257): D12529<US>
Efficacy
Antidiabetic, Antiobesity, Glucagon-like peptide 1 (GLP-1) receptor agonist
Comment
Treatment of hyperglycemia in people with type 2 diabetes; Treatment of obesity
Target
GLP1R [HSA:2740] [KO:K04581]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04911  Insulin secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01493  GLP-1 receptor agonist
    DG03257  Orforglipron
     D12529  Orforglipron calcium
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03257  Orforglipron
     D12529  Orforglipron calcium
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Glucagon
    GLP1R
     D12529  Orforglipron calcium (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12529
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12529
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12529
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01493  GLP-1 receptor agonist
    DG03257  Orforglipron
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03257  Orforglipron
Other DBs
CAS: 2415797-61-2
PubChem: 497620942
LinkDB
KCF data

ATOM        131
            1   C1x C    16.5200  -15.6100
            2   N1y N    16.5200  -17.0100
            3   C1y C    17.7100  -17.7100
            4   C8y C    18.9700  -17.0100
            5   C8y C    18.9700  -15.6100
            6   C1x C    17.7100  -14.9100
            7   C8y C    20.3000  -17.4300
            8   N4y N    21.0700  -16.3100
            9   N5x N    20.3000  -15.1900
            10  C8y C    22.4700  -16.3100
            11  C8x C    23.1700  -17.5000
            12  C8y C    24.5700  -17.5000
            13  C8y C    25.2700  -16.3100
            14  C8y C    24.5700  -15.1200
            15  C8x C    23.1700  -15.1200
            16  C1a C    25.2700  -13.9300
            17  X   F    26.6700  -16.3100
            18  C1a C    25.2700  -18.6900
            19  N4y N    20.7200  -18.7600
            20  C8x C    19.8800  -19.8800
            21  C8x C    20.7200  -21.0000
            22  N4y N    22.0500  -20.5800
            23  C8y C    22.0500  -19.1800
            24  O5x O    23.1700  -18.3400
            25  C8y C    23.1700  -21.4200
            26  C8x C    23.1700  -22.8200
            27  C8x C    24.3600  -23.5200
            28  C8y C    25.6200  -22.8200
            29  C8y C    25.6200  -21.4200
            30  C8y C    24.3600  -20.7200
            31  N4y N    26.9500  -23.2400
            32  N5x N    27.7200  -22.1200
            33  C8x C    26.9500  -21.0000
            34  X   F    24.3600  -19.3200
            35  C1a C    27.4400  -24.5700
            36  C1a C    17.7100  -19.1100
            37  C5a C    15.3300  -17.7100
            38  C8y C    14.1400  -17.0100
            39  O5a O    15.3300  -19.1100
            40  C8x C    14.0000  -15.6100
            41  C8y C    12.6000  -15.3300
            42  C8y C    11.9000  -16.5200
            43  N4y N    12.8100  -17.5700
            44  C8x C    11.9000  -14.1400
            45  C8y C    10.5000  -14.0700
            46  C8x C     9.8000  -15.3300
            47  C8x C    10.5000  -16.5200
            48  C1y C     9.8000  -12.8800
            49  C1x C    10.5000  -11.6900
            50  C1z C     9.8000  -10.4300
            51  O2x O     8.4000  -10.4300
            52  C1x C     7.7000  -11.6200
            53  C1x C     8.4000  -12.8800
            54  C1a C    10.7800   -9.4500
            55  C1a C     9.1000   -9.2400
            56  C1z C    12.1100  -18.7600
            57  C1x C    11.7390  -20.0898
            58  C1y C    13.0921  -19.7304
            59  C1a C    14.4451  -20.0901
            60  C8y C    10.7100  -18.7570
            61  N4x N     9.9012  -17.6384 #-
            62  C8y C     8.5874  -18.0619
            63  O7x O     8.5842  -19.4423
            64  N5x N     9.8960  -19.8719
            65  O6a O     7.4399  -17.2246
            66  Z   Ca   31.5000  -19.2500 #2+
            67  C1x C    16.5200  -15.6100
            68  N1y N    16.5200  -17.0100
            69  C1y C    17.7100  -17.7100
            70  C8y C    18.9700  -17.0100
            71  C8y C    18.9700  -15.6100
            72  C1x C    17.7100  -14.9100
            73  N5x N    20.3000  -15.1900
            74  N4y N    21.0700  -16.3100
            75  C8y C    20.3000  -17.4300
            76  N4y N    20.7200  -18.7600
            77  C8x C    19.8800  -19.8800
            78  C8x C    20.7200  -21.0000
            79  N4y N    22.0500  -20.5800
            80  C8y C    22.0500  -19.1800
            81  O5x O    23.1700  -18.3400
            82  C8y C    23.1700  -21.4200
            83  C8x C    23.1700  -22.8200
            84  C8x C    24.3600  -23.5200
            85  C8y C    25.6200  -22.8200
            86  C8y C    25.6200  -21.4200
            87  C8y C    24.3600  -20.7200
            88  X   F    24.3600  -19.3200
            89  C8x C    26.9500  -21.0000
            90  N5x N    27.7200  -22.1200
            91  N4y N    26.9500  -23.2400
            92  C1a C    27.4400  -24.5700
            93  C8y C    22.4700  -16.3100
            94  C8x C    23.1700  -17.5000
            95  C8y C    24.5700  -17.5000
            96  C8y C    25.2700  -16.3100
            97  C8y C    24.5700  -15.1200
            98  C8x C    23.1700  -15.1200
            99  C1a C    25.2700  -13.9300
            100 X   F    26.6700  -16.3100
            101 C1a C    25.2700  -18.6900
            102 C1a C    17.7100  -19.1100
            103 C5a C    15.3300  -17.7100
            104 C8y C    14.1400  -17.0100
            105 C8x C    14.0000  -15.6100
            106 C8y C    12.6000  -15.3300
            107 C8y C    11.9000  -16.5200
            108 N4y N    12.8100  -17.5700
            109 C1z C    12.1100  -18.7600
            110 C1y C    13.0921  -19.7304
            111 C1x C    11.7390  -20.0898
            112 C1a C    14.4451  -20.0901
            113 C8y C    10.7100  -18.7570
            114 N4x N     9.9012  -17.6384 #-
            115 C8y C     8.5874  -18.0619
            116 O7x O     8.5842  -19.4423
            117 N5x N     9.8960  -19.8719
            118 O6a O     7.4399  -17.2246
            119 C8x C    10.5000  -16.5200
            120 C8x C     9.8000  -15.3300
            121 C8y C    10.5000  -14.0700
            122 C8x C    11.9000  -14.1400
            123 C1y C     9.8000  -12.8800
            124 C1x C    10.5000  -11.6900
            125 C1z C     9.8000  -10.4300
            126 O2x O     8.4000  -10.4300
            127 C1x C     7.7000  -11.6200
            128 C1x C     8.4000  -12.8800
            129 C1a C    10.7800   -9.4500
            130 C1a C     9.1000   -9.2400
            131 O5a O    15.3300  -19.1100
BOND        150
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 2
            8     7   8 1
            9     8   9 1
            10    5   9 2
            11    8  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18   14  16 1
            19   13  17 1
            20   12  18 1
            21    7  19 1
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 1
            26   19  23 1
            27   23  24 2
            28   22  25 1
            29   25  26 2
            30   26  27 1
            31   27  28 2
            32   28  29 1
            33   29  30 2
            34   25  30 1
            35   28  31 1
            36   31  32 1
            37   32  33 2
            38   29  33 1
            39   30  34 1
            40   31  35 1
            41    3  36 1 #Down
            42    2  37 1
            43   37  38 1
            44   37  39 2
            45   38  40 2
            46   40  41 1
            47   41  42 1
            48   42  43 1
            49   38  43 1
            50   41  44 2
            51   44  45 1
            52   45  46 2
            53   46  47 1
            54   42  47 2
            55   48  45 1 #Up
            56   48  49 1
            57   49  50 1
            58   50  51 1
            59   51  52 1
            60   52  53 1
            61   48  53 1
            62   50  54 1 #Up
            63   50  55 1 #Down
            64   56  43 1 #Down
            65   57  58 1
            66   58  56 1
            67   56  57 1
            68   58  59 1 #Up
            69   56  60 1 #Up
            70   60  61 1
            71   61  62 1
            72   62  63 1
            73   63  64 1
            74   60  64 2
            75   62  65 2
            76   67  68 1
            77   68  69 1
            78   69  70 1
            79   70  71 1
            80   71  72 1
            81   67  72 1
            82   70  75 2
            83   75  74 1
            84   74  73 1
            85   71  73 2
            86   74  93 1
            87   93  94 2
            88   94  95 1
            89   95  96 2
            90   96  97 1
            91   97  98 2
            92   93  98 1
            93   97  99 1
            94   96 100 1
            95   95 101 1
            96   75  76 1
            97   76  77 1
            98   77  78 2
            99   78  79 1
            100  79  80 1
            101  76  80 1
            102  80  81 2
            103  79  82 1
            104  82  83 2
            105  83  84 1
            106  84  85 2
            107  85  86 1
            108  86  87 2
            109  82  87 1
            110  85  91 1
            111  91  90 1
            112  90  89 2
            113  86  89 1
            114  87  88 1
            115  91  92 1
            116  69 102 1 #Down
            117  68 103 1
            118 103 104 1
            119 103 131 2
            120 104 105 2
            121 105 106 1
            122 106 107 1
            123 107 108 1
            124 104 108 1
            125 106 122 2
            126 122 121 1
            127 121 120 2
            128 120 119 1
            129 107 119 2
            130 123 121 1 #Up
            131 123 124 1
            132 124 125 1
            133 125 126 1
            134 126 127 1
            135 127 128 1
            136 123 128 1
            137 125 129 1 #Up
            138 125 130 1 #Down
            139 109 108 1 #Down
            140 111 110 1
            141 110 109 1
            142 109 111 1
            143 110 112 1 #Up
            144 109 113 1 #Up
            145 113 114 1
            146 114 115 1
            147 115 116 1
            148 116 117 1
            149 113 117 2
            150 115 118 2
BRACKET     1     5.8100  -25.5500    5.8100   -8.4000
            1    29.4700   -8.4000   29.4700  -25.5500
            1  2
 ORIGINAL  1    1   2   3   4   5   6   9   8   7  19  20  21  22  23  24  25
            1   26  27  28  29  30  34  33  32  31  35  10  11  12  13  14  15
            1   16  17  18  36  37  38  40  41  42  43  56  58  57  59  60  61
            1   62  63  64  65  47  46  45  44  48  49  50  51  52  53  54  55
            1   39
 REPEAT    1   67  68  69  70  71  72  73  74  75  76  77  78  79  80  81  82
            1   83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98
            1   99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114
            1  115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130
            1  131

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