KEGG   DRUG: Eltrekibart
Entry
D12556                      Drug                                   
Name
Eltrekibart (USAN)
Formula
C6496H9986O2052N1726S44
Exact mass
146413.7824
Mol weight
146504.07
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYEFT SYWIHWVRQA PGQGLEWMGN ISPNSGSANY
NEKFKSRVTM TRDTSTSTVY MELSSLRSED TAVYYCAREG PYSYYPSREY YGSDLWGQGT
LVTVSSASTK GPSVFPLAPC SRSTSESTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTKTYTCN VDHKPSNTKV DKRVESKYGP PCPPCPAPEF
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSQEDPEVQ FNWYVDGVEV HNAKTKPREE
QFNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKGLPSSIEK TISKAKGQPR EPQVYTLPPS
QEEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSRLTVDK
SRWQEGNVFS CSVMHEALHN HYTQKSLSLS LG
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSIS NNLHWYQQKP GQAPRLLIYY TSRSVSGIPA
RFSGSGSGTD FTLTISSLEP EDFAVYYCGQ NNEWPEVFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H140-L214, H153-H209, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'140-L'214, H'153-H'209, H'267-H'327, H'373-H'431, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Anti-inflammatory disease
  Type
Monoclonal antibody
Comment
Treatment of hidradenitis suppurativa, ulcerative colitis and other inflammatory diseases
Target
CXCR1 (IL8RA, CD181) [HSA:3577] [KO:K04175]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CXCR1 (IL8RA, CD181)
     D12556  Eltrekibart (USAN)
Other DBs
CAS: 2484883-56-7
PubChem: 497620969
LinkDB

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