KEGG   DRUG: Imvotamab
Entry
D12567                      Drug                                   
Name
Imvotamab (USAN/INN)
Formula
C43154H66961N11627O13563S349
Exact mass
976243.9931
Mol weight
976848.8662
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFI SYTMHWVRQA PGQGLEWMGY INPRSGYTHY
NQKLKDKATL TADKSASTAY MELSSLRSED TAVYYCARSA YYDYDGFAYW GQGTLVTVSS
GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCSA SSSVSYMNWY QQKPGKAPKR
LIYDTSKLAS GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQWSSNPP TFGGGTKVEI
KGGGGSGGGG SGGGGSQEDE RIVLVDNKCK CARITSRIIR SSEDPNEDIV ERNIRIIVPL
NNRENISDPT SPLRTRFVYH LSDLCKKCDP TEVELDNQIV TATQSNICDE DSATETCYTY
DRNKCYTAVV PLVYGGETKM VETALTPDAC YPDGGGGSGG GGSGGGGSDA HKSEVAHRFK
DLGEENFKAL VLIAFAQYLQ QCPFEDHVKL VNEVTEFAKT CVADESAENC DKSLHTLFGD
KLCTVATLRE TYGEMADCCA KQEPERNECF LQHKDDNPNL PRLVRPEVDV MCTAFHDNEE
TFLKKYLYEI ARRHPYFYAP ELLFFAKRYK AAFTECCQAA DKAACLLPKL DELRDEGKAS
SAKQRLKCAS LQKFGERAFK AWAVARLSQR FPKAEFAEVS KLVTDLTKVH TECCHGDLLE
CADDRADLAK YICENQDSIS SKLKECCEKP LLEKSHCIAE VENDEMPADL PSLAADFVES
KDVCKNYAEA KDVFLGMFLY EYARRHPDYS VVLLLRLAKT YETTLEKCCA AADPHECYAK
VFDEFKPLVE EPQNLIKQNC ELFKQLGEYK FQNALLVRYT KKVPQVSTPT LVEVSRNLGK
VGSKCCKHPE AKRMPCAEDY LSVVLNQLCV LHEKTPVSDR VTKCCTESLV NRRPCFSALE
VDETYVPKEF NAETFTFHAD ICTLSEKERQ IKKQTALVEL VKHKPKATKE QLKAVMDDFA
AFVEKCCKAD DKETCFAEEG KKLVAASQAA LGL
(heavy chain A-J)
EVQLVQSGAE VKKPGESLKI SCKGSGYSFT SYWIGWVRQM PGKGLEWMGI IYPGDSDTRY
SPSFQGQVTI SADKSITTAY LQWSSLKASD TAMYYCARHP SYGSGSPNFD YWGQGTLVTV
SSGSASAPTL FPLVSCENSP SDTSSVAVGC LAQDFLPDSI TFSWKYKNNS DISSTRGFPS
VLRGGKYAAT SQVLLPSKDV MQGTDEHVVC KVQHPNGNKE KNVPLPVIAE LPPKVSVFVP
PRDGFFGNPR KSKLICQATG FSPRQIQVSW LREGKQVGSG VTTDQVQAEA KESGPTTYKV
TSTLTIKESD WLSQSMFTCR VDHRGLTFQQ NASSMCVPDQ DTAIRVFAIP PSFASIFLTK
STKLTCLVTD LTTYDSVTIS WTRQNGEAVK THTNISESHP NATFSAVGEA SICEDDWNSG
ERFTCTVTHT DLPSPLKQTI SRPKGVALHR PDVYLLPPAR EQLNLRESAT ITCLVTGFSP
ADVFVQWMQR GQPLSPEKYV TSAPMPEPQA PGRYFAHSIL TVSEEEWNTG ETYTCVVAHE
ALPNRVTERT VDKSTGKPTL YNVSLVMSDT AGTCY
(Light chain a-j)
DIVMTQTPLS SPVTLGQPAS ISCRSSQSLV YSDGNTYLSW LQQRPGQPPR LLIYKISNRF
SGVPDRFSGS GAGTDFTLKI SRVEAEDVGV YYCVQATQFP LTFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H158-H222, H269-H357, H271-hA574, H325-hJ574, H328-H348, H365-H390, H461-H470, H483-H499, H498-H509, H532-H577, H576-H585, H608-H654, H653-H771, H673-H687, H686-H697, H724-H769, H768-H777, H800-H846, H845-H856, H869-H885, H884-H895, H922-H967, H966-H975, hA22-hA96, hA136-La219, hA150-hA210, hA256-hA319, hA336-hB336, hA366-hA425, hA413-hB413, hA473-hA535, hB22-hB96, hB136-Lb219, hB150-hB210, hB256-hB319, hB366-hB425, hB473-hB535, hB574-hC425, hB473-hB535, hB574-hC574, hC22-hC96, hC136-Lc219, hC22-hC96, hC136-Lc219, hC150-hC210, hC256-hC319, hC336-hD336, hC366-hC425, hC413-hD413, hC473-hC535, hD22-hD96, hD136-Ld219, hD150-hD210, hD256-hD319, hD366-hD425, hD473-hD535, hD574-hE574, hE22-hE96, hE136-Le219, hE150-hE210, hE256-hE319, hE336-hF336, hE366-hE425, hE413-hF413, hE473-hE535, hF22-hF96, hF136-Lf219, hF150-Hf210, hF256-hF319, hF256-hF319, hF366-hF425, hF473-hF535, hF574-hG574, hG22-hG96, hG136-Lg219, hG150-hG210, hG256-hG319, hG336-hH336, hG366-hG425, hG413-hH413, hG473-hG535, hH22-hH96, hH136-Lh219, hH150-hH210, hH256-hH319, hH366-hH425, hH473-hH535, hH574-hI574, hI22-hI96, hI136-hJ219, hI150-hI210, hI256-hI319, hI336-hJ336, hI366-hI425, hI413-hJ413, hI473-hI535, hJ136-Lj219, hJ150-hJ210, hJ256-hJ319, hJ366-hJ425, hJ473-hJ535, La23-La93, La139-La199, Lb23-Lb93, Lb139-Lb199, Lc23-Lc93, Lc139-Lc199, Ld23-Ld93, Ld139-Ld199, Le23-Le93, Le139-Le199, Lf23-Lf93, Lf139-Lf199, Lg23-Lg93, Lg139-Lg199, Lh23-Lh93, Lh139-Lh199, Li23-Li93, Li139-Li199, Lj23-Lj93, Lj139-Lj199)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Monoclonal antibody
Comment
Treatment of relapsed/refractor non-Hodgkin lymphoma
Target
CD20 [HSA:931] [KO:K06466]
CD3E [HSA:916] [KO:K06451]
  Pathway
hsa04640  Hematopoietic cell lineage
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3E
     D12567  Imvotamab (USAN/INN)
    CD20
     D12567  Imvotamab (USAN/INN)
Other DBs
CAS: 2573121-53-4
LinkDB

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