KEGG   DRUG: Flotufolastat F18 gallium
Entry
D12606                      Drug                                   
Name
Flotufolastat F18 gallium (USAN);
Posluma (TN)
Product
POSLUMA (Blue Earth Diagnostics)
Formula
C63H96FN12O25Si. Ga
Exact mass
1535.5644
Mol weight
1538.3086
Structure
Remark
Product: D12606<US>
Efficacy
Diagnostic (prostatic cancer), Radioactive agent
Comment
Imaging agent for prostate cancer
Target
FOLH1 (PSMA) [HSA:2346] [KO:K14592]
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Metallocarboxypeptidases
    FOLH1 (PSMA)
     D12606  Flotufolastat F18 gallium (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12606
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12606
Other DBs
CAS: 2305081-64-3
ChEBI: 229675
LinkDB
KCF data

ATOM        103
            1   C6a C     5.2500   -9.1700
            2   C1c C     6.4400   -9.8700
            3   O6a O     4.0600   -9.8700
            4   O6a O     5.2500   -7.7700
            5   N1b N     7.6300   -9.1700
            6   C5a C     8.8200   -9.8700
            7   N1b N    10.0100   -9.1700
            8   O5a O     8.8200  -11.2700
            9   C1b C     6.4400  -11.2700
            10  C1b C     5.2500  -11.9700
            11  C6a C     5.2500  -13.3700
            12  O6a O     4.0600  -14.0700
            13  O6a O     6.4400  -14.0700
            14  C1c C    11.2000   -9.8700
            15  C6a C    12.3900   -9.1700
            16  O6a O    13.5800   -9.8700
            17  O6a O    12.3900   -7.7700
            18  C1b C    11.2000  -11.2700
            19  C1b C    12.3900  -11.9700
            20  C5a C    12.3900  -13.3700
            21  O5a O    11.2000  -14.0700
            22  N1b N    13.5800  -14.0700
            23  C1c C    13.5800  -15.4700
            24  C6a C    12.3900  -16.1700
            25  O6a O    11.2000  -15.4700
            26  O6a O    12.3900  -17.5700
            27  C1b C    14.8400  -16.1700
            28  C1b C    16.0300  -15.4000
            29  C1b C    17.2200  -16.1000
            30  N1b N    18.4100  -15.4000
            31  C5a C    19.6000  -16.1000
            32  C1b C    20.7900  -15.4000
            33  O5a O    19.6000  -17.5000
            34  C1b C    21.9800  -16.1000
            35  C5a C    23.1700  -15.4000
            36  N1b N    24.3600  -16.1000
            37  O5a O    23.1700  -14.0000
            38  C1b C    25.5500  -15.4000
            39  C1b C    26.7400  -16.1000
            40  C1b C    27.9300  -15.4000
            41  C1b C    29.1200  -16.1000
            42  C1c C    30.3100  -15.4000
            43  N1b N    31.5000  -16.1000
            44  C6a C    30.3100  -14.0000
            45  O6a O    29.1200  -13.3000
            46  O6a O    31.5000  -13.3000
            47  C5a C    32.6900  -15.4000
            48  C1c C    33.8800  -16.1000
            49  O5a O    32.6900  -14.0000
            50  N1b N    35.0700  -15.4000
            51  C1b C    33.8800  -17.5000
            52  C5a C    36.2600  -16.1000
            53  C1b C    37.4500  -15.4000
            54  O5a O    36.2600  -17.5000
            55  N1b N    32.6900  -18.2000
            56  C5a C    32.6900  -19.6000
            57  C8y C    31.5000  -20.3000
            58  O5a O    33.8800  -20.3000
            59  C8x C    30.3100  -19.6000
            60  C8x C    29.0500  -20.3000
            61  C8y C    29.0500  -21.7000
            62  C8x C    30.2400  -22.4000
            63  C8x C    31.5000  -21.7000
            64  Z   Si   27.8600  -22.4000
            65  C1d C    26.6700  -21.7000
            66  C1d C    27.8600  -23.8000
            67  X   F    26.6700  -23.1000
            68  C1a C    29.0500  -24.5000
            69  C1a C    26.6700  -20.3000
            70  C1a C    27.8600  -21.0000
            71  C1b C    38.6400  -16.1000
            72  C1c C    39.8300  -15.4000
            73  N1y N    41.0200  -16.1000
            74  C6a C    39.8300  -14.0000
            75  O6a O    38.6400  -13.3000
            76  O6a O    41.0200  -13.3000
            77  C1x C    41.7200  -20.0900
            78  C1x C    43.1200  -20.0900
            79  N1y N    41.0200  -18.9000
            80  N1y N    43.8200  -18.9000
            81  C1x C    45.0100  -16.8000
            82  C1x C    45.0100  -18.2000
            83  N1y N    43.8200  -16.1000
            84  C1x C    39.8300  -18.2000
            85  C1x C    39.8300  -16.8000
            86  C1x C    41.7200  -14.9100
            87  C1x C    43.1200  -14.9100
            88  C1b C    40.3200  -20.0900
            89  C1b C    44.5200  -20.0900
            90  C6a C    45.9200  -20.0900
            91  O6a O    46.6200  -21.2800 #-
            92  O6a O    46.6200  -18.9000
            93  C1b C    44.5200  -14.9100
            94  C6a C    43.8249  -13.6947
            95  O6a O    42.4203  -13.6889 #-
            96  O6a O    44.5178  -12.5063
            97  C6a C    41.0151  -21.3053
            98  O6a O    42.4197  -21.3111 #-
            99  O6a O    40.3222  -22.4937
            100 C1a C    27.8600  -25.2000
            101 C1a C    25.4576  -21.0000
            102 C1a C    26.6476  -24.5000
            103 Z   Ga   42.0700  -17.5000 #3+
BOND        103
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     2   9 1 #Up
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2
            13    7  14 1
            14   14  15 1
            15   15  16 1
            16   15  17 2
            17   14  18 1 #Down
            18   18  19 1
            19   19  20 1
            20   20  21 2
            21   20  22 1
            22   23  22 1 #Down
            23   23  24 1
            24   24  25 2
            25   24  26 1
            26   23  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1
            30   30  31 1
            31   31  32 1
            32   31  33 2
            33   32  34 1
            34   34  35 1
            35   35  36 1
            36   35  37 2
            37   36  38 1
            38   38  39 1
            39   39  40 1
            40   40  41 1
            41   41  42 1
            42   42  43 1
            43   42  44 1 #Down
            44   44  45 1
            45   44  46 2
            46   43  47 1
            47   47  48 1
            48   47  49 2
            49   48  50 1
            50   48  51 1 #Down
            51   50  52 1
            52   52  53 1
            53   52  54 2
            54   51  55 1
            55   55  56 1
            56   56  57 1
            57   56  58 2
            58   57  59 2
            59   59  60 1
            60   60  61 2
            61   61  62 1
            62   62  63 2
            63   57  63 1
            64   61  64 1
            65   64  65 1
            66   64  66 1
            67   64  67 1
            68   66  68 1
            69   65  69 1
            70   65  70 1
            71   53  71 1
            72   71  72 1
            73   72  73 1
            74   72  74 1 #Up
            75   74  75 1
            76   74  76 2
            77   77  78 1
            78   77  79 1
            79   78  80 1
            80   81  82 1
            81   82  80 1
            82   81  83 1
            83   84  79 1
            84   84  85 1
            85   85  73 1
            86   86  87 1
            87   87  83 1
            88   86  73 1
            89   88  79 1
            90   89  90 1
            91   89  80 1
            92   90  91 1
            93   90  92 2
            94   93  83 1
            95   93  94 1
            96   94  95 1
            97   94  96 2
            98   88  97 1
            99   97  98 1
            100  97  99 2
            101  66 100 1
            102  65 101 1
            103  66 102 1

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