KEGG   ORTHOLOGY: K14592
Entry
K14592                      KO                                     
Symbol
FOLH1, GCPII
Name
glutamate carboxypeptidase II (folate hydrolase 1) [EC:3.4.17.21]
Pathway
map00250  Alanine, aspartate and glutamate metabolism
map01100  Metabolic pathways
map04977  Vitamin digestion and absorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
 09150 Organismal Systems
  09154 Digestive system
   04977 Vitamin digestion and absorption
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.21  glutamate carboxypeptidase II
     K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M28: aminopeptidase Y family
   K14592  FOLH1, GCPII; glutamate carboxypeptidase II (folate hydrolase 1)
Other DBs
RN: R10687 R10688
Genes
HSA: 2346(FOLH1)
PTR: 451185 451475(FOLH1B)
PPS: 100970802 100980316
GGO: 101147888 101149915
PON: 100453848(FOLH1B)
NLE: 100589099(FOLH1B)
MCC: 707714(FOLH1B)
MCF: 101866140(FOLH1B)
CSAB: 103248197(FOLH1B)
CATY: 105592968(FOLH1B)
PANU: 101022396
TGE: 112606075(FOLH1B)
RRO: 104678909(FOLH1B)
RBB: 108539153(FOLH1B)
TFN: 117080629(FOLH1B)
PTEH: 111540744(FOLH1B)
CJC: 100396945(FOLH1B)
SBQ: 101044541(FOLH1B)
CSYR: 103271409
OGA: 100962089(FOLH1B)
MMU: 53320(Folh1)
MCAL: 110297451(Folh1b)
MPAH: 110325375(Folh1b)
RNO: 85309(Folh1)
MCOC: 116100637(Folh1b)
MUN: 110562303
CGE: 100768684
PLEU: 114682738(Folh1b)
NGI: 103750517(Folh1)
HGL: 101725016(Folh1b)
CPOC: 100712916(Folh1b)
CCAN: 109696834
DORD: 106000547(Folh1b)
DSP: 122115932(Folh1b)
NCAR: 124960251
OCU: 100358060(FOLH1)
OPI: 101520191(FOLH1B)
TUP: 102487205(FOLH1B)
CFA: 476775(FOLH1)
VVP: 112915749
VLG: 121476478
AML: 100472805
UMR: 103675371(FOLH1B)
UAH: 113269424(FOLH1B)
UAR: 123803814
ELK: 111154494
LLV: 125078783
MPUF: 101694251(FOLH1B)
EJU: 114199711(FOLH1B)
ZCA: 113913704(FOLH1B)
MLX: 118013456(FOLH1B)
FCA: 101089641(FOLH1B)
PYU: 121039399(FOLH1B)
PBG: 122483225(FOLH1B)
PTG: 102957765(FOLH1B)
PPAD: 109267331(FOLH1B)
AJU: 106983063(FOLH1B)
HHV: 120246246(FOLH1B)
BTA: 505865(FOLH1B)
BOM: 102272952(FOLH1B) 106700854
BIU: 109554596(FOLH1B)
BBUB: 102406997(FOLH1B)
CHX: 102190665(FOLH1B)
OAS: 101121723
ODA: 120874817(FOLH1B)
CCAD: 122431256(FOLH1B)
SSC: 397677(FOLH1B)
CFR: 102510657(FOLH1B)
CBAI: 105083514(FOLH1B)
CDK: 105088594(FOLH1B)
VPC: 102545019(FOLH1B)
BACU: 103001153
LVE: 103089873
DLE: 111170975
PCAD: 102979651(FOLH1B)
PSIU: 116758197
ECB: 100060132(FOLH1B)
EPZ: 103547857(FOLH1B)
EAI: 106822677(FOLH1B)
MYB: 102258767(FOLH1B)
MYD: 102761189(FOLH1B)
MMYO: 118664536(FOLH1B)
MLF: 102429206
MNA: 107532373
PKL: 118712526(FOLH1B)
HAI: 109374041(FOLH1B)
DRO: 112315970(FOLH1B)
SHON: 118984760
AJM: 119044483
PDIC: 114499474(FOLH1B)
PHAS: 123805618(FOLH1B)
MMF: 118627580(FOLH1B)
RFQ: 117031190(FOLH1B)
PALE: 102895068
PGIG: 120590541(FOLH1B)
PVP: 105294194(FOLH1B)
RAY: 107514943(FOLH1B)
MJV: 108390597(FOLH1B)
LAV: 100660135(FOLH1B)
TMU: 101357352
DNM: 101438576
MDO: 100009990(FOLH1B)
GAS: 123240544(FOLH1B)
SHR: 100918727(FOLH1B)
PCW: 110213435(FOLH1B)
OAA: 100081512
GGA: 419011(FOLH1)
PCOC: 116241925
CJO: 107308462
NMEL: 110390755
APLA: 101790444
ACYG: 106034162
AFUL: 116489852
TGU: 100223080
LSR: 110478412
SCAN: 103827252
PMOA: 120506649
OTC: 121341016(FOLH1B)
PRUF: 121362303
GFR: 102034877(FOLH1B)
FAB: 101814982(FOLH1)
PHI: 102105283(FOLH1B)
PMAJ: 107211745
CCAE: 111924890
CCW: 104690325(FOLH1B)
ETL: 114063504(FOLH1B)
ZAB: 102066126
FPG: 101918547
FCH: 102058819
CLV: 102095234
EGZ: 104128839
NNI: 104017386(FOLH1B)
ACUN: 113476470
TALA: 104355464
PADL: 103926056
ACHC: 115353314
AAM: 106495541
AROW: 112973711(FOLH1B)
NPD: 112949989
DNE: 112988580
ASN: 102387587
AMJ: 102569346(FOLH1B)
CPOO: 109306785
GGN: 109302806(FOLH1B)
PSS: 102455710(FOLH1B)
CMY: 102934118
CPIC: 101934265(FOLH1B)
TST: 117871229(FOLH1B)
CABI: 116818087
MRV: 120389099(FOLH1B)
ACS: 100551729
SUND: 121927293
PBI: 103055697
PMUR: 107295569
TSR: 106554598
PGUT: 117660097(FOLH1B)
VKO: 123029330
PMUA: 114595614(FOLH1B)
ZVI: 118085476(FOLH1B)
GJA: 107124070
XLA: 108707586
XTR: 100485577(folh1)
NPR: 108794765(FOLH1B)
LOC: 102692081
PCHN: 125044036
PCLA: 123769093
DSV: 119446373
RSAN: 119374961
RMP: 119166833
VDE: 111254558
VJA: 111258992
CRG: 105349101
EPA: 110233909
AMIL: 114956456
PDAM: 113679020
SPIS: 111322624
 » show all
Reference
PMID:9685395
  Authors
Halsted CH, Ling EH, Luthi-Carter R, Villanueva JA, Gardner JM, Coyle JT
  Title
Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II.
  Journal
J Biol Chem 273:20417-24 (1998)
DOI:10.1074/jbc.273.32.20417
  Sequence
[ssc:397677]
Reference
  Authors
Guo J, Xie H, Wang J, Zhao H, Wang F, Liu C, Wang L, Lu X, Bao Y, Zou J, Wang G, Niu B, Zhang T
  Title
The maternal folate hydrolase gene polymorphism is associated with neural tube defects in a high-risk Chinese population.
  Journal
Genes Nutr 8:191-7 (2013)
DOI:10.1007/s12263-012-0309-3
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