KEGG   DRUG: Avitotamig
Entry
D12721                      Drug                                   
Name
Avitotamig (USAN)
Formula
C8920H13658N2414O2824S66
Exact mass
201888.0905
Mol weight
202012.78
Sequence
(Heavy chain)
DIQMTQSPSS LSASVGDRVT ITCKASQDIN KYIAWYQHKP GKAPKLLIYY ASNLQPGVPS
RFSGSGSGRD FTFTISSLQP EDIATYYCLQ YDNLLTFGAG TKLELKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GECTSGGGGS GGGGSGGGGS QVQLVQSGGG
VVQPGRSLRL SCKASGYTFT RYTMHWVRQA PGKCLEWIGY INPSRGYTNY NQKFKDRFTI
SRDNSKNTAF LQMDSLRPED TGVYFCARYY DDHYSLDYWG QGTPVTVSSG GGGSGGGGSG
GGGSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCSASSSVSY MNWYQQTPGK
APKRWIYDTS KLASGVPSRF SGSGSGTDYT FTISSLQPED IATYYCQQWS SNPFTFGCGT
KLQITR
(Light chain)
QVQLQQSGAE VVKPGASVKV SCKASGYSFT DYNMYWVRQA PGQGLEWMGY IDPYKGGTIY
NQKFQGRATL TRDTSISTAY MELSRLRSDD TAVYYCAREM ITAYYFDYWG QGSSVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYAS
TYRVVSVLTV LHQDWLNGKE YKCAVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Disulfide bridge: H23-H88, H133-H193, H213-L222, H252-H326, H274-H478, H402-H466, H'23-H'88, H'133-H'193, H'213-L'222, H'252-H'326, H'274-H'478, H'402-H'466, L22-L96, L146-L202, L228-L'228, L231-L'231, L263-L323, L369-L427, L'22-L'96, L'146-L'202, L'263-L'323, L'369-L'427)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Monoclonal antibody, bispecific antibody
Comment
Treatment of acute myeloid leukemia
Target
CD33 (SIGLEC3) [HSA:945] [KO:K06473]
CD3E [HSA:916] [KO:K06451]
  Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Cell adhesion molecules: Ig superfamiy
   SIGLEC family
    CD33 (SIGLEC3)
     D12721  Avitotamig (USAN)
  Other cell surface molecules
   CD molecules
    CD3E
     D12721  Avitotamig (USAN)
Other DBs
PubChem: 497621134
LinkDB

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